Weight-Loss drug tirzepatide tested to boost breast cancer outcomes

NCT ID NCT06518837

Recruiting now Disease control Sponsor: Rutgers, The State University of New Jersey Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether tirzepatide, a drug used for weight loss, can help patients with early-stage hormone receptor-positive, HER2-negative breast cancer lose at least 5% of their body weight during adjuvant treatment. The trial will enroll 40 adults and also check safety, side effects, and long-term outcomes like cancer recurrence. The goal is to see if weight loss can improve overall health and treatment success.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tirzepatide
What this could lead to: If it works, this could point toward a way to improve treatment outcomes and reduce recurrence risk in early-stage breast cancer patients through weight loss.
What could go wrong: This is a small, early-phase feasibility study with only 40 participants. It may not show clear benefits, and tirzepatide can cause side effects like nausea or digestive issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Her2-receptor negative breast cancer hormone receptor-positive breast cancer Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HER2-NEGATIVE BREAST CANCER HORMONE RECEPTOR POSITIVE BREAST CANCER

Contacts and locations

Locations

RWJ Barnabas Health - Robert Wood Johnson University Hospital, Hamilton
NOT_YET_RECRUITING

Hamilton, New Jersey, 08690, United States
RWJ Barnabas Health - Robert Wood Johnson University Hospital, Somerset
RECRUITING

Somerville, New Jersey, 08876, United States
RWJBarnabas Health - Cooperman Barnabas, Livingston
RECRUITING

Livingston, New Jersey, 07039, United States
RWJBarnabas Health - Monmouth Medical Center
RECRUITING

Long Branch, New Jersey, 07740, United States
RWJBarnabas Health - Newark Beth Israel Medical Center
RECRUITING

Newark, New Jersey, 07112, United States
Rutgers Cancer Institute
RECRUITING

New Brunswick, New Jersey, 08901, United States
Trinitas Comprehensive Cancer Center
RECRUITING

Elizabeth, New Jersey, 07202, United States

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