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Can a 2-Week PTSD therapy cut substance use? new trial aims to find out

NCT ID NCT06968832

Recruiting now Symptom relief Sponsor: Rutgers, The State University of New Jersey Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a condensed form of PTSD therapy, called Massed Prolonged Exposure (M-PE), can help people who are also being treated for substance use disorders. About 168 adults will either receive M-PE alongside their usual substance use program or continue with standard care. Researchers will track PTSD symptoms, substance use, and quality of life over six months to see if the fast-track therapy leads to better outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Massed Prolonged Exposure Therapy (M-PE)
What this could lead to
If it works, this could provide an effective way to treat PTSD alongside substance use treatment, improving mental health and reducing substance use.
What could go wrong
This is a relatively small trial (168 participants) and compares M-PE to usual care, so results may not apply to all settings. The therapy is intensive and may not be suitable for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute stress disorder post-traumatic stress disorder substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMORBIDITY POSTTRAUMATIC STRESS DISORDER (PTSD) SUBSTANCE USE DISORDERS (SUD) TRAUMA AND STRESSOR RELATED DISORDERS

Contacts and locations

Locations

  • Gateway Community Services

    RECRUITING

    Jacksonville, Florida, 32204, United States

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