POSTTRAUMATIC STRESS DISORDER (PTSD)

This study is testing if a more intensive form of therapy for PTSD (Post-Traumatic Stress Disorder) works better for people who are also in treatment for substance use problems. It compares a condensed schedule of therapy sessions to the usual care. The goal is to see if this app…

This study is testing a new therapy called HOPE for people who have both opioid addiction and post-traumatic stress disorder (PTSD). Participants must already be taking medication for their opioid addiction. The research will compare whether adding this 10-12 week therapy to stan…

This study is testing if a newer type of talk therapy, called transdiagnostic Metacognitive Therapy (tMCT), works better than the current standard therapy, Cognitive-Behavioral Therapy (CBT), for adults with anxiety disorders. It will involve 86 people in Sweden diagnosed with Ge…

This small pilot study is testing whether a self-guided version of eye movement therapy (A-EMDR) can help people who have both post-traumatic stress disorder (PTSD) and substance use problems. The research team wants to see if this therapy reduces PTSD symptoms and substance use …

This study is testing whether a specially adapted form of talk therapy, delivered by video call, can help treat PTSD in adults who are receiving medication for opioid addiction at syringe service programs. The main goal is to see if offering this therapy onsite is practical and a…

This study is testing whether a single dose of ayahuasca (a traditional plant brew) or esketamine (a ketamine-based medicine) can help reduce symptoms of post-traumatic stress disorder (PTSD). It's a small, early-stage trial with 10 participants who have PTSD but no other major h…

This study is testing whether combining two talk therapies—one for PTSD and one for suicide prevention—works better than standard care to reduce suicidal thoughts and behaviors. The research involves 190 military personnel and veterans who have both PTSD symptoms and recent suici…

This study is testing whether a low dose of a medication called dexmedetomidine, which is already used to sedate patients in intensive care, can help people with PTSD sleep better. Twenty-four adults with PTSD and ongoing sleep problems will spend three nights in a sleep lab, try…

This study is testing if methylphenidate (a stimulant medication often used for ADHD) can help Veterans with PTSD who struggle with concentration, memory, and keeping up with tasks. Over 20 weeks, 70 participants will alternate between taking the medication and a placebo (inactiv…

This study aims to understand if short-term inflammation in the body changes how people process fear, which is a key problem in PTSD. Researchers will give some participants a typhoid vaccine to cause temporary inflammation and others a placebo, then measure their fear responses.…

This study aims to understand how the brain processes fear in people with PTSD. Researchers will test a gentle, non-invasive brain stimulation technique to see if it can calm overactive fear networks and reduce symptoms like anxiety and hypervigilance. The study will compare 80 p…

This study aims to see if using a visual life history calendar helps people in Hong Kong remember their mental health history more accurately. Researchers will compare the standard mental health interview with and without the calendar tool. The goal is to improve how we measure h…

This study aims to understand how the brain works in people with PTSD and test if a gentle, non-invasive electrical brain stimulation can help calm anxiety and hypervigilance. Researchers will compare 80 healthy adults and 80 people with PTSD, giving some the real stimulation and…