POSTTRAUMATIC STRESS DISORDER (PTSD)

This study tests whether a rapid, intensive form of PTSD therapy (Massed Prolonged Exposure) can help adults in a substance use program reduce both PTSD symptoms and substance use. About 168 participants will either receive this therapy or standard care, and be followed for 6 mon…

This study tests whether a special type of talk therapy for PTSD, delivered by video at syringe service programs, is practical and helpful for adults who are also taking medication for opioid use disorder. Researchers want to see if the therapy reduces PTSD symptoms and helps par…

This study looks at whether a 6-week mindfulness program can reduce PTSD symptoms and improve quality of life for people who were in a road traffic accident. About 110 adults with PTSD will either get the mindfulness training or standard care. Researchers will track changes using…

This study tests a new therapy called A-EMDR, where people use eye movements on their own to help with PTSD and substance use problems. 24 adults with both conditions will try A-EMDR or continue their usual care for 4 weeks. Researchers will check if symptoms and substance use im…

This study compares two psychological treatments for anxiety disorders: standard cognitive-behavioral therapy (CBT) and a newer approach called metacognitive therapy (MCT). MCT focuses on changing beliefs about worrying itself, rather than the content of worries. The trial will e…

This study tests whether adding a brief crisis coping strategy (Crisis Response Planning) to a standard PTSD talk therapy (Cognitive Processing Therapy) can reduce suicidal thoughts and behaviors in veterans and active-duty service members. About 190 participants with PTSD and re…

This study tests a therapy called HOPE for people who have both opioid use disorder and PTSD. Participants must already be on medication for opioid use disorder, like suboxone or methadone. Over 10 to 12 weeks, they will attend therapy sessions and complete surveys to see if thei…

This study tests whether a single dose of ayahuasca or esketamine can ease symptoms of posttraumatic stress disorder (PTSD). Ten adults with PTSD will receive one of the two treatments in a double-blind, randomized setup. The goal is to see if either drug reduces PTSD symptoms qu…

This study tests if methylphenidate (a medication used for ADHD) can improve PTSD symptoms and related thinking problems like poor memory and concentration in Veterans. About 70 Veterans will take turns receiving the drug or a placebo every 4-5 weeks over 20 weeks. The goal is to…

This study tests a two-week intensive outpatient program for adults with PTSD. Up to 42 participants will receive daily trauma-focused therapy and be followed for 12 weeks. Researchers will measure changes in PTSD symptoms and quality of life using questionnaires and interviews. …

This study tests a medication called RE03 (dexmedetomidine) to see if it can improve sleep in people with PTSD who have trouble sleeping. About 24 adults with PTSD and sleep issues will receive either the drug or a placebo in a crossover design. The goal is to measure time spent …

This study looks at whether short-term changes in the immune system affect how people with PTSD process fear. Participants will receive either a typhoid vaccine or a placebo, then have their body responses measured while listening to sounds. The goal is to better understand the l…

This study looks at how the brain works in people with PTSD, focusing on areas that control alertness and fear. Researchers will use brain scans and EEG to measure activity, then test if a gentle electrical current (tACS) can help calm overactive brain circuits. The goal is to un…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve how accurately adults in Hong Kong remember and report past mental health problems. Researchers will compare the standard interview method with the cale…

This study looks at how the brain processes threats in people with PTSD. Researchers will use a gentle electrical current (tACS) to see if it can calm overactive brain areas linked to anxiety and hypervigilance. The goal is to understand the brain's role in PTSD and test a potent…