New HOPE therapy aims to tackle opioid addiction and PTSD together

NCT ID NCT06641115

Recruiting now Symptom relief Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a therapy called HOPE for people who have both opioid use disorder and PTSD. Participants must already be on medication for opioid use disorder (like Suboxone or methadone). Over 10-12 weeks, they will attend therapy sessions and complete surveys to see if their opioid use and PTSD symptoms improve.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HOPE therapy (behavioral therapy)
What this could lead to: If it works, this could provide an effective integrated therapy for people struggling with both opioid addiction and PTSD, potentially improving recovery outcomes.
What could go wrong: This is a small early-stage study with only 76 participants, so results may not apply to everyone. The therapy is intensive (10-12 weeks) and may not work for all individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

opiate dependence post-traumatic stress disorder Psychological Well-Being substance-related disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OPIOID-USE DISORDER POSTTRAUMATIC STRESS DISORDER (PTSD)

Contacts and locations

Locations

Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29403, United States

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