Single dose of ayahuasca or esketamine could ease PTSD symptoms
NCT ID NCT07317206
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a single dose of ayahuasca or esketamine can reduce symptoms of posttraumatic stress disorder (PTSD). Ten adults with PTSD will receive one of the two drugs in a double-blind design. The goal is to see if either substance can provide rapid relief from PTSD symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ayahuasca or esketamine
What this could lead to
If it works, this could point toward a new, fast-acting treatment option for PTSD that uses a single dose.
What could go wrong
This is a very small early-phase trial with only 10 participants, so results may not apply widely. Both substances can cause intense psychological effects and are not proven safe or effective for PTSD yet.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hospital das Clínicas da FMRP-USP
RECRUITINGRibeirão Preto, São Paulo, 14049900, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••