BLADDER CANCER

This early-phase study tested a combination of two drugs—CG0070 (given directly into the bladder) and nivolumab (given through an IV)—in 21 people with muscle-invasive bladder cancer who could not receive the standard chemotherapy drug cisplatin. The main goal was to check safety…

This study tested a drug called pemigatinib in 30 people with a type of bladder cancer that keeps coming back. Participants took the drug for 4-6 weeks before their scheduled surgery to remove the tumor. The goal was to see if the drug could completely eliminate the cancer before…

This study tested a new treatment approach for muscle-invasive bladder cancer. It compared a combination of two drugs (enfortumab vedotin and pembrolizumab) given before and after surgery to the standard chemotherapy before surgery. The goal was to see if the new combination help…

This early-phase study tested the safety of giving different doses of external radiation therapy together with the chemotherapy drug gemcitabine for people with bladder cancer. Nineteen patients with early-stage bladder cancer that had not spread to lymph nodes or other organs to…

This study tested two chemotherapy combinations in 500 bladder cancer patients to see which works better before or after bladder removal surgery. One group received gemcitabine plus cisplatin, the other a high-dose version of MVAC. The goal was to see which regimen delays cancer …

This study tested the drug pembrolizumab (Keytruda) alone or with other medicines in 296 people with high-risk bladder cancer that did not get better after standard BCG therapy. Participants were not able or willing to have their bladder removed. The goal was to see if the treatm…

This study tested whether giving a short, intensive course of chemotherapy (Mitomycin C) before surgery can lower the chance of bladder cancer coming back, compared to the usual approach of surgery followed by chemotherapy. 120 adults with recurrent non-muscle invasive bladder ca…

This study tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy (gemcitabine and cisplatin) could shrink tumors more effectively before bladder removal surgery in people with muscle-invasive bladder cancer. 39 participants received the co…

This study tested a combination of two drugs (toripalimab and gemcitabine) given before surgery to people with muscle-invasive bladder cancer who cannot take the standard chemotherapy drug cisplatin. The goal was to see how well the drugs shrink tumors before the bladder is remov…

This early-stage study tested a new drug called UGN-301 (zalifrelimab) in 51 people with recurrent non-muscle invasive bladder cancer. The drug was given directly into the bladder to see if it is safe and to find the best dose. The goal is to control the cancer and prevent it fro…

This study tested whether freezing some cancer spots (cryoablation) plus immunotherapy drugs (pembrolizumab or avelumab) could shrink tumors in people with advanced bladder cancer that has spread. Nine adults with metastatic urothelial carcinoma took part. The goal was to see if …

This study tested a new way to give radiotherapy to people with muscle-invasive bladder cancer who cannot have standard surgery or daily radiation. Instead of daily treatments, patients received higher doses once a week for a shorter time. The study also looked at whether using d…

This study tested a drug called BGJ398 in 4 people with a type of bladder cancer that stayed in the bladder lining and had returned after standard treatment. The drug targets a specific genetic change (FGFR3 mutation) found in their tumors. The main goal was to see if the drug co…

This study tested whether a closed-system bladder irrigation device could lower the chance of urinary tract infections in 240 adults after prostate or bladder tumor surgery. Patients were randomly assigned to the new device or standard care. The closed system keeps the catheter s…

This study tested several immunotherapy drug combinations in 272 people with advanced bladder cancer that had worsened after standard chemotherapy. The goal was to see if these combinations could shrink tumors or slow the disease. Participants could switch to a different combinat…

This study tested a new drug called enfortumab vedotin against standard chemotherapy in 608 adults with advanced bladder or urinary tract cancer that had worsened after prior treatment. The goal was to see if the new drug helped people live longer and slowed cancer growth. Result…

This study looked at whether a care plan led by a geriatrician and a nurse could help older adults (70+) with cancer live longer and feel better. It included 792 people with different cancers like breast, lung, or prostate. The approach was compared to usual cancer care to see if…

This study looked at whether a special type of MRI, called multiparametric MRI, can more accurately determine how far bladder cancer has spread. Knowing the exact stage helps doctors choose the right treatment—surgery alone for early-stage tumors or chemotherapy plus surgery for …

This study tested whether a special type of PET/MR scan can accurately detect if chemotherapy has completely eliminated muscle-invasive bladder cancer. 13 patients were scanned after chemotherapy, and the results were compared to tissue removed during surgery. The goal was to see…

This study tested a new imaging agent called 89Zr-girentuximab to see if it can help detect non-muscle-invasive bladder cancer (NMIBC) using PET/CT scans. Six adults with confirmed NMIBC received the agent and were monitored for safety and how well the scans could spot cancer cel…

This study looked at a new urine test called VISIOCYT to see if it can better detect bladder tumors than standard urine tests. Over 700 patients who were either suspected of having bladder cancer or being monitored for it provided urine samples before their regular cystoscopy. Th…

This study tested two ways to numb the obturator nerve during bladder tumor surgery to prevent sudden leg muscle spasms that can cause complications. Sixty patients aged 50-80 were randomly assigned to receive either a single-injection or a two-injection nerve block. The goal was…

This study tested a program to help bladder cancer patients and their caregivers prepare for and recover from bladder removal surgery. The program included nurse-led education before surgery, a recovery website with videos and resources, and support for both patients and caregive…

This study tested whether using Fitbits and daily smartphone surveys after bladder cancer surgery could help doctors spot problems early and reduce hospital readmissions. 38 adults who had bladder removal surgery were randomly assigned to either standard care or extra remote moni…

This early-phase study tested whether a nutritional drink called Impact Advanced Recovery, taken before and after bladder removal surgery, could lower the risk of complications. Thirty men with bladder cancer participated. The goal was to see if the drink could improve immune res…

This study looked at CT scans from 316 bladder cancer patients to see if a computer model could predict if the cancer would come back after surgery. The goal was to improve how doctors assess risk. The study did not test a new treatment but aimed to better understand recurrence p…

This study looked at how well the drug T-DXd works compared to usual treatments for people with several types of advanced cancers that have high levels of a protein called HER2. Researchers used existing data from earlier trials and real-world medical records to compare outcomes.…

This study looked at whether measuring tiny bits of tumor DNA in blood and urine (called ctDNA) is possible in people with muscle-invasive bladder cancer receiving standard treatment. Researchers collected samples before, during, and after therapy to see if ctDNA levels could hel…

This study looked at how immune checkpoint inhibitors, a type of cancer drug, might harm blood vessels and speed up artery disease. Researchers followed 39 cancer patients before and after starting these drugs, using ultrasound and blood tests to track changes. The goal was to be…

This study analyzed health records from over 2 million people with type 2 diabetes to see if those taking the drug dapagliflozin had a different risk of developing breast or bladder cancer compared to those on other diabetes medications. Researchers followed participants for up t…

This study tested a web-based app called STOMA Care to see if it is acceptable and helpful for bladder or colorectal cancer patients who need ostomy surgery and their caregivers. The app provides information and tools to improve stoma care knowledge, skills, and emotional well-be…

This study looked at people with advanced solid tumors (like lung, bladder, or skin cancer) who had been on immunotherapy (PD-1/PD-L1 inhibitors) for one year and whose disease was stable. It randomly assigned them to either stop treatment or continue until their cancer got worse…

This study tested a new tool called the Personal Patient Profile for Bladder Cancer (P3-BC) to help patients who need bladder removal surgery make informed decisions. The tool aims to improve communication with doctors and prepare patients for follow-up care. The study involved 2…