BLADDER CANCER

This early-stage study tested whether higher doses of targeted radiation therapy could be safely given alongside chemotherapy to treat bladder cancer. Researchers worked with 19 patients who had bladder cancer that hadn't spread to other parts of the body. The main goal was to fi…

This study tested whether adding a specialized geriatric care team to standard cancer treatment could help older patients. It involved 792 patients aged 70 and older with various advanced cancers. The goal was to see if this coordinated care approach improved survival and quality…

This study tested whether freezing one tumor site (cryoablation) could help the body's immune system work better when combined with immunotherapy drugs (pembrolizumab or avelumab) for people with advanced bladder cancer that has spread. The goal was to see if this combination cou…

This study tested whether intensive chemotherapy delivered directly to the bladder could control recurrent bladder cancer and potentially avoid surgery for some patients. It compared this intensive chemo approach against the standard treatment of surgery followed by chemo in 120 …

This study tested whether an oral medicine called BI 907828 could help control advanced cancers of the bile duct, pancreas, lung, or bladder that had a specific genetic pattern (MDM2 amplified, TP53 wild-type) and had stopped responding to standard treatments. All 99 participants…

This small pilot study tested whether an oral drug called BGJ398 could shrink tumors in patients with a specific type of recurrent bladder cancer. It involved 4 adults whose cancer had returned after standard treatment and who had a particular genetic mutation. The goal was to se…

This study tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy could better shrink tumors before bladder removal surgery. It involved 39 adults with muscle-invasive bladder cancer who were scheduled for surgery. The goal was to see if th…

This study tested several different immunotherapy-based drug combinations for people with advanced bladder cancer that had worsened after standard chemotherapy. It involved 272 participants and was designed to quickly find and stop treatments that didn't work well while advancing…

This study tested whether giving a combination of two drugs (toripalimab and gemcitabine) before bladder removal surgery could help shrink tumors in patients who couldn't receive standard chemotherapy. The trial involved 50 adults with muscle-invasive bladder cancer who were sche…

This study tested whether remote monitoring could help patients recover better at home after major bladder cancer surgery. Researchers gave some patients a Fitbit and used a smartphone app for daily check-ins, with the goal of spotting health issues early. If the system detected …

This study tested whether a new drug called enfortumab vedotin helped people with advanced bladder cancer live longer than standard chemotherapy. It involved 608 adults whose cancer had spread or returned after previous treatments with immunotherapy and platinum-based chemotherap…

This UK study tested a shorter, weekly radiotherapy schedule for patients with muscle-invasive bladder cancer who were not healthy enough for standard surgery or daily radiation. It compared a standard treatment plan to a newer 'adaptive' method that could adjust the radiation fi…

This study tested if taking a targeted pill called pemigatinib for 4-6 weeks could shrink or eliminate recurrent, non-invasive bladder tumors before standard surgery. It involved 30 patients with a history of low- or intermediate-risk tumors that had come back. The main goal was …

This study aimed to find the best length of immunotherapy treatment for people with advanced cancers. It enrolled 161 patients whose cancer had remained stable after one year of treatment. Researchers randomly assigned participants to either stop their immunotherapy or continue i…

This study tested pembrolizumab, an immunotherapy drug, for people with high-risk bladder cancer that didn't respond to standard BCG treatment and who couldn't or wouldn't have bladder removal surgery. The trial involved 296 participants and aimed to see if pembrolizumab alone or…

This early-stage study tested the safety of a new drug called UGN-301 for people with recurring non-muscle invasive bladder cancer. The drug was delivered directly into the bladder, both by itself and combined with other treatments. The main goal was to find a safe dose and under…

This small, early-stage study tested the safety of a two-part treatment for muscle-invasive bladder cancer in patients who could not receive standard chemotherapy. The treatment combined a modified cold virus (CG0070) placed directly into the bladder with an immunotherapy drug (n…

This large, completed Phase 3 trial tested if a new combination of two immunotherapy/targeted drugs (enfortumab vedotin plus pembrolizumab) given before and after surgery works better than the current standard chemotherapy (gemcitabine plus cisplatin) for people with muscle-invas…

This study compared two different chemotherapy combinations for people with advanced bladder cancer who need treatment before or after bladder removal surgery. Researchers tested whether a more intensive four-drug combination (HD-MVAC) works better than the standard two-drug comb…

This study evaluated a new urine test called VISIOCYT to see how well it detects bladder cancer compared to standard methods. Researchers tested 701 patients who were already scheduled for routine bladder exams, either for initial suspicion of cancer or for follow-up monitoring. …

This study looked back at 316 bladder cancer patients to see if a special analysis of their CT scans could predict who was most likely to have their cancer return after surgery. Researchers developed a computer model using scan images taken before patients had their bladder remov…

This study tested whether advanced MRI scans could help doctors better determine how deeply bladder cancer has grown into the bladder wall. Researchers enrolled 186 patients with bladder cancer to see if these detailed scans could improve staging accuracy compared to standard met…

This small, early study tested a new imaging method for non-muscle-invasive bladder cancer. Researchers gave six patients a special 'tagged' antibody designed to stick to cancer cells, then used PET/CT scans to see if it made the tumors easier to spot. The main goals were to chec…

This study tested a special imaging scan (15O-H2O PET/MR) to see if it could accurately tell which patients with muscle-invasive bladder cancer had their tumor completely eliminated by chemotherapy before surgery. The goal was to identify patients who might safely avoid having th…

This study compared two different ways of numbing a leg nerve to prevent sudden, involuntary muscle spasms during surgery to remove bladder tumors. Sixty patients aged 50-80 were randomly assigned to receive either a newer, single-injection nerve block or a standard two-injection…

This study tested a support program designed to help bladder cancer patients and their caregivers through the challenging recovery period after bladder removal surgery. The program combined in-person nurse coaching before surgery with access to a special recovery website after su…

This study tested a mobile app called 'STOMA Care' to see if it was helpful and easy to use for people with bladder or colorectal cancer who were getting an ostomy and their caregivers. The app provided information, videos, and support to help with stoma care skills, reduce distr…

This study tested whether a blood test that looks for tiny pieces of cancer DNA could be used to monitor people with muscle-invasive bladder cancer. One participant undergoing standard treatment had their blood and urine collected at different times. The main goal was to see if c…