BLADDER CANCER

This phase 3 trial tests whether a combination of enfortumab vedotin and pembrolizumab, given before and after bladder removal surgery, works better than standard chemotherapy for muscle-invasive bladder cancer. About 800 participants will be randomly assigned to one of the two t…

This trial compared two blood thinners—apixaban (a pill) and enoxaparin (a shot)—in 126 bladder cancer patients after bladder removal surgery. The goal was to see which one patients were more likely to take as prescribed, which they preferred, and what it cost them. Participants …

This pilot study tested whether adding the anti-inflammatory drug celecoxib (Celebrex) to standard chemotherapy before bladder cancer surgery is safe and affects tumor genes. 22 people with muscle-invasive bladder cancer took part. The goal was to see how the treatment changed ca…

This early-phase study tested a personalized cancer vaccine (RO7198457) in 273 patients with advanced solid tumors like melanoma, lung, and breast cancer. The vaccine was given alone or with an immunotherapy drug (atezolizumab) to see if it was safe and how the body responded. Th…

This study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy before and after bladder removal surgery helps people with muscle-invasive bladder cancer live longer without the cancer coming back. About 900 participants took part. The goal was to s…

This study compared two types of surgery to remove the bladder in people with bladder cancer: one done with a robot and one done as open surgery. About 339 patients took part across multiple hospitals. The main goal was to see which approach let patients spend more days at home a…

This study tested an experimental drug called BMS-986016 (anti-LAG-3) alone or combined with nivolumab in people with advanced solid tumors that had spread or couldn't be removed by surgery. It included several cancer types like lung, stomach, liver, kidney, bladder, head and nec…

This study tested a closed-system bladder irrigation device designed to reduce urinary tract infections after endoscopic urologic surgery. 240 patients undergoing prostate or bladder tumor surgery were randomly assigned to use the new device or standard irrigation. The device all…

This study tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy (gemcitabine and cisplatin) could shrink tumors more effectively before bladder cancer surgery. 39 people with muscle-invasive bladder cancer received the combination before …

This study tested the safety of combining different doses of external radiation therapy with the chemotherapy drug gemcitabine in 19 bladder cancer patients. The goal was to find the highest safe dose of radiation that can be given alongside chemo. Participants had early-stage bl…

This study tested whether giving a short, intensive course of the chemotherapy drug Mitomycin C before surgery (chemoresection) could lower the chance of bladder cancer coming back, compared to the usual approach of surgery followed by regular chemotherapy instillations into the …

This early-stage study tested a combination of two drugs—CG0070 (a virus that targets cancer cells) and nivolumab (an immunotherapy that boosts the immune system)—in 21 people with muscle-invasive bladder cancer who were not eligible for standard chemotherapy. The goal was to see…

This study tested two or three drugs together in adults with advanced solid tumors (cancers that have spread). The main goal was to find the safest dose and see if the combination can shrink tumors. Participants took brigimadlin pills and received ezabenlimab infusions every 3 we…

This pilot study tested a drug called BGJ398 in 4 people with a type of bladder cancer that stays in the bladder lining but keeps coming back after standard treatment. The drug targets tumors with a specific genetic change (FGFR3 mutation or fusion). The main goal was to see if t…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

This completed phase 2 trial tested a combination of cryoablation (freezing tumors with a needle) and immunotherapy drugs (pembrolizumab or avelumab) in 9 people with metastatic bladder cancer. The goal was to see if this approach could shrink tumors that were not frozen. The stu…

This study tested several immunotherapy-based drug combinations in 272 people with advanced bladder cancer that had worsened after platinum chemotherapy. The goal was to see which combinations were safest and most effective at shrinking tumors or slowing the disease. Participants…

This study tested a weekly, higher-dose radiation schedule (hypofractionated radiotherapy) for people with muscle-invasive bladder cancer who cannot have standard daily radiation or surgery. It included 65 participants and compared standard radiation planning with a newer 'adapti…

This early-phase trial tested a new drug called UGN-301 (zalifrelimab) given directly into the bladder for people with recurrent non-muscle invasive bladder cancer. The study included 51 participants and aimed to check safety and find the right dose, both alone and with other dru…

This study tested a new drug called enfortumab vedotin against standard chemotherapy in 608 adults with advanced bladder or urinary tract cancer that had spread or come back after prior treatment. The goal was to see if the new drug helped people live longer and slowed cancer gro…

This study tested a combination of two drugs (toripalimab and gemcitabine) given before surgery to 50 people with muscle-invasive bladder cancer who cannot take the standard chemotherapy drug cisplatin. The goal was to see how many patients had their tumors shrink or disappear. T…

This phase II trial tested the immunotherapy drug pembrolizumab (Keytruda) alone or with another agent in 296 people with high-risk non-muscle-invasive bladder cancer that did not respond to standard BCG therapy. Participants received the drug intravenously every three weeks. The…

This study tested two different chemotherapy drug combinations in 500 people with advanced bladder cancer that had not spread to other organs. The goal was to see which treatment worked better at stopping the cancer from coming back after surgery. Participants received either gem…

This phase 2 trial tested pemigatinib, a daily pill that blocks certain growth signals, in 30 people with recurrent low- or intermediate-risk non-muscle invasive bladder cancer. Participants took the drug for 4-6 weeks before their standard surgery to remove bladder tumors. The m…

This pilot study tested whether a new radioactive tracer called 18F-fluciclovine, used with a PET/CT scan, can better determine the extent of muscle invasive bladder cancer before surgery. Sixteen participants with bladder cancer received the tracer and scan before their planned …

This study tested whether analyzing urine with a special light technique (spectroscopy) can accurately detect bladder cancer. Researchers collected urine samples from 899 people undergoing cystoscopy. The goal was to see if the light patterns could tell apart those with cancer fr…

This study tested how well a special MRI scan (called multiparametric MRI) can tell if bladder cancer has grown into the muscle layer of the bladder. Researchers used a scoring system called VI-RADS to interpret the scans. The study included 60 people with bladder masses who were…

This study looked at whether a new urine test called VISIOCYT can better detect bladder tumors than standard methods. Over 700 patients undergoing cystoscopy (a scope procedure) provided urine samples for both standard and VISIOCYT analysis. The goal was to see how accurate the n…

This study tested whether a special type of PET/MR scan (using radioactive water) can accurately tell if bladder cancer has been completely eliminated by chemotherapy. 13 patients with muscle-invasive bladder cancer were scanned before and after chemotherapy, and the results were…

This early-phase study tested a new imaging agent called 89Zr-girentuximab in 6 people with non-muscle-invasive bladder cancer. The goal was to see if it could safely and clearly show tumors on PET/CT scans. Researchers looked for uptake spots in the bladder and checked for side …

This study tested whether advanced MRI scans can better determine how deeply bladder cancer has grown into the bladder wall. Accurate staging is crucial because it decides whether a patient needs just surgery or also chemotherapy and bladder removal. The study enrolled 186 people…

This early-phase trial tested whether a nutritional supplement called Impact Advanced Recovery® could help men recover better after bladder cancer surgery. Thirty men took the drink before and after their operation. The goal was to see if it reduced surgical complications, infect…

This study tested two ways to numb the obturator nerve during bladder tumor surgery to prevent sudden leg muscle spasms that can cause complications. Sixty patients aged 50-80 were randomly assigned to receive either a single-injection or a two-injection nerve block. The goal was…

This study tested a program to help bladder cancer patients and their caregivers prepare for and recover from bladder removal surgery. A nurse or health professional provided pre-surgery education and stoma care training, and patients got access to a recovery website with videos …

This completed study compared two ways to control pain after radical cystectomy (bladder removal) surgery: thoracic epidural analgesia (TEA) and ultrasound-guided erector spinae plane (ESP) block. Twenty patients aged 40-70 were enrolled. The goal was to see which method provides…

This study looked at whether three proteins (E-cadherin, β-catenin, and SOX4) can help predict if non-muscle invasive bladder cancer will return or get worse after surgery. Researchers examined tissue samples from 30 patients who had bladder tumor removal. The goal was to see if …

This study analyzes data from 748 patients who had their bladder removed due to bladder cancer. The goal is to find factors that can predict whether cancer has spread to the ureter, the tube that carries urine from the kidney to the bladder. By identifying these factors, doctors …

This study developed an AI model to predict how well bladder cancer responds to treatment before surgery. Researchers used data from 469 patients, including medical images and genetic information, to train the AI. The goal is to help doctors choose the best treatment plan for eac…

This study tested whether an AI tool can help health providers write medical summaries that are easier for patients to understand. 120 providers were split into two groups: one used the AI tool, the other did not. The goal was to see if AI could improve readability and save time,…

This study tested a new online tool called the Personal Patient Profile for Bladder Cancer (P3BC) in 24 patients who were facing bladder removal surgery. The tool provides personalized information, videos, and summaries to help patients talk with their doctors and prepare for rec…

This completed study analyzed health records from over 2 million people with type 2 diabetes to see if those taking dapagliflozin had a different risk of breast or bladder cancer compared to those on other diabetes medications. Researchers tracked cancer diagnoses for up to 12 ye…

This study looked at how immune checkpoint inhibitors, a type of cancer drug, might affect blood vessels and increase heart risks. Researchers measured blood vessel function and checked for related markers in 39 cancer patients before and after starting treatment. The goal was to…

This study looks at whether the drug T-DXd works better than standard treatments for people with several types of HER2-positive solid tumors. Researchers will compare data from previous T-DXd trials with real-world medical records of patients who received standard care. The goal …

This study looked at how bladder cancer surgery (cystectomy) affects patients' sexual quality of life over time. Researchers gave 50 participants questionnaires before and 8 months after surgery to track changes. The goal is to better understand long-term effects that are often o…

This study looked at people with advanced solid tumors (like lung, bladder, or melanoma) who had been on immunotherapy for one year and whose disease was stable. Half stopped treatment and half continued. The goal was to see if stopping early affected how long until the cancer pr…

This study tested whether using at-home monitoring devices (like a wristband pedometer, scale, and blood pressure cuff) can help improve care for cancer patients after they leave the hospital following surgery. 22 patients with various cancers participated. The goal was to see if…

This study looked at whether measuring bits of tumor DNA in blood and urine (called ctDNA) is possible in people with muscle-invasive bladder cancer receiving a combination of surgery, radiation, and chemotherapy. The goal was to see if this approach could help monitor how well t…

This study looked at CT scans from 316 bladder cancer patients to see if a computer model could predict whether the cancer would come back after surgery. The goal was to find patterns in the scans that might help doctors identify high-risk patients earlier. This is a research stu…

This study tested whether using Fitbits and daily smartphone surveys after bladder cancer surgery can help doctors catch problems early and reduce hospital readmissions. 38 patients participated, with half receiving the remote monitoring program. The goal was to see if this appro…

This study tested a web-based app called STOMA Care to see if it is practical and helpful for bladder or colorectal cancer patients getting ostomy surgery and their family caregivers. Researchers measured how well the app worked by tracking recruitment, retention, and changes in …