BLADDER CANCER

This study is testing a combination of two drugs, enfortumab vedotin and pembrolizumab, for patients with high-grade cancer in their kidney or ureter who are not candidates for or refuse the standard surgery to remove the organ. The goal is to see if this drug treatment can contr…

This study is testing whether adding a new immunotherapy drug (toripalimab) to a standard bladder cancer treatment (BCG) can better control high-risk bladder cancer. The goal is to help patients avoid having their bladder surgically removed. The study will enroll 31 patients to s…

This study is comparing two standard surgical methods for bladder cancer. It will see if patients do better with or without a temporary plastic tube (a ureteral stent) placed during surgery to remove the bladder. Researchers will track 70 patients for a year to measure complicati…

This early-stage study is testing the safety of a new two-drug immunotherapy combination, with or without a precise form of radiation, for adults with advanced urinary tract cancers that have spread. The goal is to see if these treatments can work together to help the body's own …

This study is testing whether washing the bladder with a combination of two chemotherapy drugs (gemcitabine and docetaxel) can help prevent low-grade bladder cancer from coming back. The treatment is given directly into the bladder through a catheter. Researchers will track how w…

This is a first-in-human safety study testing a new two-part treatment for people with advanced HER2-positive solid tumors that have stopped responding to standard therapies. First, a specially designed virus is injected directly into one tumor to help alert the immune system. A …

This is the first study in people testing a new drug called EVOLVE104. It aims to find a safe dose and see if it can help control advanced bladder and several types of squamous cell cancers. The study is for patients whose cancer has continued to grow despite standard treatments.

This study is testing whether using MRI scans during radiation treatment can help doctors target cancer more precisely while patients receive chemotherapy. Researchers want to see if this approach is safe and practical for treating gastric and breast cancers. The study involves 7…

This study is testing a combination of three treatments—an immunotherapy drug (atezolizumab), a new immune-stimulating drug (BDB001), and targeted radiation—to see if they can better control advanced solid tumors. It is enrolling 247 adults with specific advanced cancers, includi…

This early-stage study is testing the safety and effects of an experimental cancer drug called PF-08046876 in adults with advanced solid tumors. The drug is an antibody drug conjugate designed to target and kill cancer cells. Researchers will give the drug through an IV to about …

This study is testing a new combination treatment designed to control high-risk bladder cancer while allowing patients to keep their bladder. It combines a precise freezing technique performed during tumor removal with immunotherapy and low-dose chemotherapy. The goal is to see i…

This is the first study in people testing a new cancer drug called MGC026. It aims to find a safe dose and see if the drug can help shrink tumors in adults with advanced solid tumors that have not responded to other treatments. The study will also check how the drug moves through…

This is an early-stage study testing a new oral drug called BG-68501 in people with advanced solid tumors that have spread or cannot be removed by surgery. The main goals are to find a safe dose and see how the body processes the drug, both when given alone and when combined with…

This program provides access to an investigational drug called ulixertinib for patients with advanced cancers that have specific genetic changes (MAPK pathway mutations). It is for people who have run out of other treatment options. The drug aims to control the cancer's growth, e…

This study is testing whether using MRI scans instead of CT scans to guide radiation therapy for gynecologic cancers can reduce side effects and improve treatment accuracy. Researchers at Johns Hopkins will compare how well MRI helps doctors target tumors while sparing healthy or…

This study is testing whether a new, precise radiation planning technique can protect the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine or rectal cancer. The goal is to prevent radiation from causing early menopause, which can lead to ser…

This early-stage study is testing a new oral drug called CP-383 in people with advanced solid tumors that have spread or returned. The main goals are to find a safe dose and see if the drug can slow or stop cancer growth. It is for patients who have run out of standard treatment …

This study is testing a new medicine called MK-3120 for people with high-risk bladder cancer that is still in the lining of the bladder and hasn't spread to the muscle. The medicine is placed directly into the bladder. The main goals are to see if the treatment is safe and if peo…

This study is testing a special pre-surgery program designed to help frail patients get stronger before major cancer surgery. The program includes nutrition advice, breathing exercises, and physical training. Researchers want to see if this preparation helps patients have fewer c…

This study is testing whether giving patients IV fluids at home after major bladder cancer surgery helps them recover better and avoid being readmitted to the hospital. About 130 patients at Johns Hopkins will be randomly assigned to either receive the home IV fluid program along…

This study is testing whether it is safe to combine a new targeted drug called tarlatamab with standard radiation therapy. It is for adults with advanced cancers that have a specific protein called DLL3, including certain lung cancers, melanoma, and others. The main goal is to se…

This study is testing whether washing the bladder with two cancer drugs, one after the other, can help control high-risk bladder cancer in patients whose cancer did not respond to the standard BCG treatment. The trial aims to see if this approach can prevent the cancer from comin…

This study is testing whether a support program called CARES helps rural cancer patients start treatment sooner and complete it faster. The program provides navigation help and counseling sessions alongside usual cancer care. Researchers will compare outcomes for 320 patients who…

This trial tests a new type of immune cell therapy called 4SCAR-T for people with advanced bladder cancer that has spread and who have run out of standard treatment options. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cancer cell…

This study is testing whether drinking special nutritional supplements before bladder removal surgery helps patients recover with fewer complications. Researchers will compare patients who receive the supplements to those who do not, looking at infection rates and overall recover…

This study is testing new combinations of cancer drugs for people with advanced bladder cancer that has spread. The first part aims to find the safest doses of two drugs. The second part will test how well these two drugs work together, and also test a three-drug combination, to …

This study is testing a more precise form of radiation therapy called an 'adaptive boost' for prostate and bladder cancer. It aims to see if this approach can control the cancer while causing fewer side effects like urinary or bowel problems. The study will enroll 60 adults who a…

This is a first-in-human study testing a new drug called CLSP-1025 for adults with advanced solid tumors that have a specific genetic change called the p53 R175H mutation. The main goals are to find a safe dose and see if the drug can help control the cancer. The drug works by en…

This study is testing a new type of radiation therapy called lattice radiation (LRT) for people with large cancer tumors that have spread to soft tissues. It compares LRT to standard radiation to see which is better at shrinking tumors and attracting immune cells to fight the can…

This is a first-in-human study to find a safe and effective dose of a new drug called ONM-501. The drug is injected directly into tumors and is being tested alone and in combination with an approved immunotherapy drug (cemiplimab) in adults with advanced cancers that have stopped…

This study is testing if rinsing the bowel segment used to create a new urine system with a common antiseptic (chlorhexidine) during and after bladder removal surgery can prevent infections. The goal is to see if this rinse helps keep the urine sterile and reduces the number of p…

This study is testing whether combining a targeted cancer drug (enfortumab vedotin) with precise radiation therapy can help shrink tumors before bladder removal surgery. It's for patients with muscle-invasive bladder cancer who cannot receive standard cisplatin chemotherapy. The …

This study is testing if using a special blue light during bladder cancer surgery helps doctors see and remove more of the cancer compared to the standard white light. Researchers want to see if this leads to less cancer left behind and a lower chance of the cancer coming back. A…

This study aims to help bladder cancer patients recover better after major surgery. It will test if using a small urine drainage tube (stent) or a bowel recovery drug (alvimopan) helps patients leave the hospital sooner and reduces infections. About 530 patients will be randomly …

This study is testing a new way to choose chemotherapy drugs for patients after surgery for muscle-invasive bladder cancer. Researchers will grow tiny 3D models of a patient's own tumor in the lab and test different chemotherapy drugs on them to see which ones work best. The goal…

This study is testing whether adding a new experimental drug to the current standard treatment is safe and more effective for people with advanced bladder cancer. It will involve about 55 participants who have not yet received treatment for their advanced cancer. The main goals a…

This study is testing a new type of treatment called EBNK-001, which uses donated immune cells (Natural Killer cells) to fight cancer. It is for adults with advanced solid tumors that have grown or returned after standard treatments. The main goals are to find a safe dose and see…

This is a first-in-human study to test the safety and find the right dose of a new investigational drug called LY4052031 for people with advanced or metastatic solid tumors. The drug is designed to target a specific protein found on many cancer cells, delivering its medicine dire…

This early-stage study is testing a new drug, IDE892, both alone and in combination with another drug called IDE397. It is for adults with advanced solid tumors that have a specific genetic change called MTAP deletion and have stopped responding to standard treatments. The main g…

This study compares two surgical approaches for bladder cancer removal in men. Researchers want to see if leaving more prostate tissue intact during surgery helps preserve sexual function without compromising cancer treatment. The study will follow 70 men for two years, tracking …

This study is testing whether a combination of chemotherapy and immunotherapy can effectively treat muscle-invasive bladder cancer, with the goal of allowing patients to keep their bladder instead of needing surgery to remove it. About 36 adults with localized bladder cancer will…

This first-in-human study is testing an experimental cancer treatment called IDOV-Immune, which uses a modified virus designed to infect and destroy cancer cells while boosting the immune system. The trial aims to find the safest dose and check for early signs that the treatment …

This study is testing a new method to personalize chemotherapy for muscle-invasive bladder cancer. Researchers will grow miniature 3D models of a patient's tumor in the lab to test which chemotherapy drugs work best before treatment begins. They will compare survival rates for pa…

This is the first human study of an experimental cancer drug called LY4101174. Researchers want to find a safe dose and see if it can help control advanced cancers that have spread or returned after other treatments. The study will enroll about 490 people with various solid tumor…

This study is testing whether a special health check-up before surgery, followed by support from a senior care team, helps older and frailer bladder cancer patients. The goal is to help them recover better after major surgery, spend fewer days in the hospital, and improve their q…

This program provides access to an investigational treatment called cretostimogene for people with a specific type of bladder cancer that has not responded to the standard BCG therapy. It is for patients who are not eligible for or refuse surgery to remove their bladder. The trea…

This study is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in people with advanced solid tumors that have spread or cannot be removed by surgery. The goal is to see if the drug can shrink tumors and control the disease in people who have already tried at l…

This study is for people with advanced bladder cancer that has continued to grow despite receiving a specific prior combination treatment. It will compare a new drug combination (datopotamab deruxtecan plus a platinum chemotherapy) against a standard chemotherapy combination. The…

This study aims to find the best treatment approach for older adults with advanced bladder cancer who cannot tolerate standard chemotherapy. Researchers will compare two different treatment combinations to see which provides better quality of life with fewer side effects. The stu…

This study compares two approaches for treating recurrent high-grade bladder cancer that hasn't spread into the muscle wall. Researchers want to understand whether keeping the bladder with medication treatments or removing it surgically leads to better financial outcomes, quality…

This study aims to see how well the drug T-DXd works in real-world settings for patients with advanced HER2-positive cancers who have already tried other treatments and have no good options left. It will follow about 100 patients with various solid tumors (excluding breast, lung,…

This study is testing if a non-invasive urine test can help doctors decide which patients with early-stage bladder cancer need a second surgery. Currently, many patients get a second surgery to check for leftover cancer, but it might not be needed for everyone. The goal is to use…

This study is testing a new combination of two cancer drugs (enfortumab vedotin and pembrolizumab) given alongside targeted radiation therapy. The goal is to see if this approach can effectively control muscle-invasive bladder cancer for patients who are not candidates for, or wh…

This study is testing a new, personalized method to choose the best drug for patients with advanced bladder cancer that has spread or cannot be removed by surgery. Researchers will grow tiny 3D models of a patient's own tumor in the lab to test which drug it responds to best, and…

This study is testing whether a combination of three drugs (adebrelimab, etoposide, and cisplatin) given before bladder removal surgery can help shrink or eliminate a rare and aggressive form of bladder cancer called neuroendocrine carcinoma. About 22 patients with this specific …

This study is testing whether taking PET scan images 2.5 hours after injection, instead of the standard 1 hour, improves the detection of cancer spread to lymph nodes in patients with muscle-invasive bladder cancer. Researchers will compare the accuracy of the delayed images agai…

This study is testing a new diagnostic platform called IT-TCP that analyzes tumor samples from patients with high-risk cancers. Researchers will collect samples from 300 patients with various cancers including leukemia, pancreatic cancer, and melanoma to see if this detailed anal…

This study is testing whether a simple rectal mucus sample can detect lung, pancreatic, bladder, and colorectal cancers by looking for DNA changes. Researchers will collect samples from 450 people using a special swab device to see if cancer-related genetic markers appear in the …

This study is developing and testing a new type of genetic test for bladder cancer. The goal is to create a more affordable and sensitive test that can check for many cancer-related genetic changes at once. Researchers will use it on tissue samples from 400 patients to see if it …

This study aims to find out if women aged 50 and older who have blood in their urine from a sudden bladder infection need to go through the full set of tests to check for cancer. Researchers will follow 300 women for a year after they get standard tests like a bladder scope and a…

This study is testing a new urine test that might help detect returning bladder cancer without needing invasive camera exams. Researchers will compare the new test against current methods in 300 people with a history of bladder cancer who are being monitored for recurrence. The g…

This study aims to see if a shorter, non-contrast MRI scan is as accurate as the standard, more complex MRI for determining if bladder cancer has invaded the muscle wall. Researchers will compare the two scan types in 58 patients suspected of having bladder cancer. The goal is to…

This study is testing a new urine test that aims to predict whether bladder cancer patients will respond to standard BCG immunotherapy. Currently, about half of patients don't benefit from BCG treatment, leading to additional therapies or bladder removal surgery. The test measure…

This study is testing a new urine test to better detect bladder cancer in people who have small amounts of blood in their urine that can't be seen by the naked eye. The goal is to create a more accurate, non-invasive test so fewer people need to undergo an uncomfortable camera ex…

This study is testing a new type of imaging scan to see if it can better detect and monitor many different solid tumors. The scan uses a special tracer that attaches to a protein called Trop2, which is often found on cancer cells. Researchers will compare this new scan to standar…

This study is testing whether a non-invasive urine test that looks for cancer DNA can help doctors decide when patients with high-risk bladder cancer need a follow-up cystoscopy. Cystoscopy is an effective but uncomfortable camera exam of the bladder. Researchers want to see if u…

This study is testing whether a non-invasive urine test can help doctors decide which patients with high-risk bladder cancer truly need a second surgery. Currently, many patients get this second procedure as a precaution, but it carries risks and costs. Researchers will compare t…

This study is testing a new approach to diagnosing invasive bladder cancer. It compares the standard surgical biopsy method against a new method that uses a detailed MRI scan first, followed by a smaller biopsy on the same day. The goal is to see if the MRI method helps patients …

This study is testing a new imaging substance called [18F]FAPI-74 to see if it can detect certain cancers better than current standard scans. It will involve 320 adults with one of 10 specific cancer types who are scheduled for treatment. Participants will receive both the new tr…

This study is testing a new blood test designed to detect many types of cancer early, before symptoms appear. It will involve 7,000 people, both with and without cancer, to see if the test can accurately spot cancer signals and identify where in the body the cancer started. The t…

This study is testing if a new type of PET/CT scan, called a 68Gallium PSMA-PET/CT scan, can find cancer that has spread in people with advanced bladder cancer or melanoma. Researchers want to see if this new scan works as well as or better than the standard scans doctors current…

This study is testing a new diagnostic platform that uses artificial intelligence to analyze small pieces of a patient's tumor. The goal is to predict whether a patient's cancer will respond to immunotherapy drugs before they start treatment. Researchers will compare the AI's pre…

This study aims to find the best time to send encouraging messages to help older cancer survivors be more physically active. Researchers will test if receiving a message makes participants more likely to be active in the next hour and if it affects their pain levels over the next…

This study aims to create and test a counseling program to help bladder cancer patients manage sexual health problems that often arise after treatment. Researchers will first interview patients to understand their specific challenges and needs. Then, they will test the new suppor…

This study is testing whether watching educational videos before bladder removal surgery helps older patients recover better. Researchers want to see if learning strategies from the videos can reduce problems like difficulty moving, medication issues, and poor quality of life aft…

This study is testing if a personalized home exercise program, delivered through a smartphone app, can help people with bladder cancer get stronger before their surgery. About 128 patients will be randomly assigned to either use the exercise app or receive standard educational ma…

This study is testing whether providing extra educational support can help women with bladder cancer feel less demoralized and improve their sexual function. Researchers will enroll 80 women and randomly assign them to receive either standard care or standard care plus a special …

This study compares how well the cancer drug T-DXd works compared to standard treatments for patients with advanced HER2-positive solid tumors. Researchers will analyze existing medical records from about 105 patients who received either T-DXd in previous trials or standard care …

This study is creating a collection of blood, urine, and tissue samples from people with bladder cancer. Researchers will use this 'biorepository' to study how bladder cancer develops, returns after treatment, and affects survival over time. The study involves 1,000 participants …

This large international study is collecting information on a new, more precise type of radiation therapy that uses real-time MRI scans to guide treatment. It aims to see if this advanced technology helps people with many types of cancer live longer, better control their tumors, …

This study collects tumor tissue samples from cancer patients to research whether laboratory tests can predict which patients will respond to immunotherapy drugs. Researchers will analyze how live tumor samples react to immunotherapy treatments in the lab, then compare those resu…

This study is testing a modified surgical tool to see if it can provide better information about bladder cancer tumors. Researchers will use the tool on bladders that have already been surgically removed from patients for medical reasons. The goal is to see if this new method of …

This study aims to collect blood, urine, saliva, and tissue samples from people with bladder or urinary tract cancer, as well as from healthy volunteers. Researchers will compare these samples to learn what genetic and cellular changes cause this cancer to develop. The goal is to…

This study is testing a new artificial intelligence (AI) tool designed to help match people with advanced cancer to suitable clinical trials. It will enroll up to 50,000 patients to see if using this AI system makes it easier for patients to find and join trials. The researchers …

This study aims to understand and improve how hospitals around the world treat patients who are urgently admitted with blood in their urine (hematuria). Researchers will observe the care of about 1,050 adult patients to see how different treatment approaches affect hospital stay …

This study aims to understand how bladder cancer treatment affects the body's energy use and muscle function. Researchers will measure these changes in 30 patients undergoing chemotherapy and surgery. The goal is to gather information that could help design better supportive care…

This study aims to understand the course of rare cancers in the urinary system (like bladder, kidney, and prostate cancers) by tracking patients over time. Researchers will collect medical information, blood, urine, and sometimes tumor samples from about 1,100 adults with these c…

This study aims to collect and store blood, urine, stool, saliva, and tumor samples from 500 bladder cancer patients at Toulouse University Hospital. Researchers want to understand how bacteria in the bladder and gut might affect how patients respond to cancer treatments like BCG…

This study aims to understand how major surgeries for bladder, prostate, and kidney cancers, as well as procedures for kidney stones, affect patients' ability to return to their jobs and their overall quality of life. Researchers will survey 2000 adult patients in Poland about th…

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…

This study aims to understand how bladder cancer is currently treated in Russia and how often certain biomarkers (HER2 and PD-L1) are present in tumors. It will observe 600 adult patients with different stages of bladder cancer during a single routine visit. The study does not te…

This study collects blood, urine, and tissue samples from people with or suspected of having cancers of the kidney, bladder, prostate, and other urinary system cancers. The samples are stored in a tissue bank and used for research to understand the genetic causes of these cancers…

This study is creating a detailed registry to track how patients recover after surgery to remove the bladder for cancer treatment. Researchers will collect information from 2,000 patients about their symptoms and recovery experiences. The goal is to establish a baseline so future…

This study screens adults with various cancers to see if they qualify for experimental treatments being tested by the National Cancer Institute's Surgery Branch. Participants undergo tests and evaluations to determine their eligibility for specific treatment trials. The study als…

This study aims to see if changes in what people buy—like pain relief or digestive aids—can serve as an early warning sign for certain cancers. Researchers will compare the shopping history of 1,450 recently diagnosed cancer patients with 1,450 people without cancer, using up to …

This study is creating a large registry to gather real-world information on how well a special blue light scope works for detecting and managing early-stage bladder cancer. It will follow 4,400 patients over five years to see if this technology helps doctors find more cancers, pe…