BLADDER CANCER

This early-phase trial is testing a new drug called ATO-101 for people with a type of bladder cancer (non-muscle-invasive) that has come back after standard treatments like BCG therapy. The drug delivers a short-range radioactive particle directly to cancer cells in the bladder, …

This study tests a drug called entinostat combined with standard chemotherapy for people with advanced bladder cancer that has gotten worse after initial treatment. The goal is to see if this combination can shrink tumors or slow the disease. About 29 adults with measurable tumor…

This study tests a treatment called HIVEC, which delivers heated chemotherapy directly into the bladder. It is for people with high-grade bladder cancer that has not spread into the muscle wall, but who cannot have or refuse bladder removal surgery. The goal is to see if this app…

This study tests a program called Primary Care Connect (PC2) for cancer survivors who also have heart-related conditions like high blood pressure, diabetes, or high cholesterol. The goal is to see if the program helps them stay connected to their primary care doctor and better ma…

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study will test whether a special PET scan (FAPI PET) and two urine tests can more accurately detect and stage bladder cancer. About 262 adults with bladder cancer will receive the scan and provide urine samples before standard treatment. The goal is to see if these tests ca…

This study looks at whether skipping a routine urine culture before bladder tumor surgery is just as safe as doing one. The goal is to prevent serious urinary infections after the operation. About 2,600 adults scheduled for bladder tumor surgery will take part. Half will get the …

This study tests a new type of radiation therapy that adapts to the bladder's changing shape during treatment. The goal is to reduce bowel side effects like diarrhea in people with muscle-invasive bladder cancer who cannot have surgery. About 120 participants will be randomly ass…

This study tests whether comfort-enhancing steps—like timing numbing gel, playing calming music, or using visual distractions—can reduce pain and anxiety during flexible cystoscopy or bladder instillation in bladder cancer patients. About 378 adults will be randomly assigned to r…

This study looks at stored tumor samples from 100 people who had bladder cancer surgery. Researchers want to see if the mix of cancer cells, supportive tissue, and immune cells can help predict who will do better after surgery. The goal is to find new ways to personalize treatmen…

This study explores whether analyzing tumor DNA found in urine can be a simple, non-invasive way to monitor prostate and bladder cancer. Researchers will collect urine samples from 25 patients at different treatment stages to see if the test works well. The goal is to develop a u…