BLADDER CANCER

This study is testing whether adding a drug called entinostat to standard chemotherapy can help control advanced bladder cancer that has stopped responding to initial treatment. It will involve about 29 patients whose cancer cannot be surgically removed and has spread. The main g…

This study is testing whether washing the bladder with two chemotherapy drugs, gemcitabine and docetaxel, can control high-risk bladder cancer that has stopped responding to the standard BCG treatment. The goal is to see if this approach can effectively treat the cancer and preve…

This first-in-human study is testing a new treatment called ATO-101™ for people with a specific type of bladder cancer that has not responded to standard therapies. The treatment involves placing a radioactive antibody directly into the bladder to target and destroy cancer cells …

This study is testing whether a more personalized form of radiation therapy can reduce severe side effects for people with muscle-invasive bladder cancer. It will compare a new 'adaptive' technique, which adjusts the radiation daily based on bladder changes, against standard radi…

This study is for people with advanced bladder cancer that has continued to grow despite previous treatments. Researchers want to see if a new drug called sacituzumab tirumotecan helps patients live longer compared to standard non-platinum chemotherapy options. About 590 particip…

This early-stage study is testing a new cell-based treatment called SL-28 in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find the safest and most effective dose and to check for side effects. Participants will receive the…

This study is testing whether a daily pill called dutasteride can prevent low-grade bladder cancer from returning after initial surgery. It will involve 95 men and women who have had this type of cancer removed. The goal is to see if this simple, well-tolerated treatment can redu…

This study is testing if adding a very precise, high-dose radiation treatment to standard drug therapies helps people with bladder cancer that has spread to only a few other places in the body. It will compare the standard treatment alone to the standard treatment plus this targe…

This study is testing whether a urine test that detects cancer DNA can help doctors decide when to safely stop immunotherapy in patients with a high-risk form of bladder cancer that cannot be fully removed by surgery. About 53 patients will receive immunotherapy and be monitored …

This study is testing a heated chemotherapy wash for the bladder in patients with high-risk bladder cancer that has not responded to standard treatments and who cannot have their bladder surgically removed. About 50 participants will receive the heated treatment weekly for six we…

This study tests whether a new care coordination program helps cancer patients better manage chronic conditions like high blood pressure, diabetes, and high cholesterol during cancer treatment. Researchers will compare patients who receive the new program to those getting usual c…

This study aims to see if a new type of PET scan (FAPI PET/CT) combined with a urine test can more accurately detect and determine the stage of bladder cancer. It will involve 262 adults with suspected or confirmed bladder cancer. Researchers will compare the results of these new…

This study aims to collect videos from a special blue light bladder scan procedure to train an artificial intelligence (AI) tool. The goal is to help doctors more accurately spot suspicious areas that could be bladder cancer during the scan. The research involves 500 adults who a…

This study aims to see if doctors can safely skip a routine urine test given before surgery to remove bladder tumors. Researchers want to know if not doing this test leads to the same low rate of post-surgery fevers and infections, while potentially reducing unnecessary antibioti…

This study aims to see if simple comfort measures can make routine bladder cancer check-ups less stressful and painful. Researchers will test interventions like calming music, visual distractions, and optimized timing of numbing gel on 378 patients. They will compare these patien…

This study is testing whether analyzing cancer DNA in urine can help doctors monitor prostate and bladder cancer without invasive procedures. Researchers will collect urine samples from 25 patients at different points during their standard cancer treatments to see if the test wor…