New stem cell combo aims to tame leukemia in older patients
NCT ID NCT06195891
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests a stem cell therapy called Orca-T combined with targeted radiation and chemotherapy for people aged 60-75 with acute leukemias or myelodysplastic syndrome. The goal is to see if this approach is safe and can reduce side effects while effectively treating the cancer. About 33 participants will receive donor stem cells with specially engineered immune cells to improve tolerance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Orca-T cells (donor stem cells with partially engineered T cells)
What this could lead to
If it works, this could offer a safer stem cell transplant option for older adults with blood cancers, reducing side effects and improving outcomes.
What could go wrong
This is a very early phase 1 trial with only 33 people, so it's mainly checking safety and dosing. The treatment involves strong chemo and radiation, which carry serious risks like infection and organ damage.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Medical Center
RECRUITINGDuarte, California, 91010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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