Rash or remission? new study aims to decode drug side effect in rare skin cancers

NCT ID NCT07003100

Recruiting now Knowledge-focused Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tracks 100 adults with mycosis fungoides or Sézary syndrome who are starting mogamulizumab, a standard treatment. The drug often causes a rash that can look like the cancer itself. Researchers want to help doctors tell the difference so they don't stop a working drug too soon. Participants will have skin biopsies and blood tests to study the rash.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mogamulizumab
What this could lead to: If successful, this study could help doctors accurately identify mogamulizumab-associated rash, preventing unnecessary early stopping of a working treatment.
What could go wrong: This is an observational study, not a treatment trial, so it won't directly improve outcomes. The rash may still be hard to distinguish from disease progression in some cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

mycosis fungoides mycosis fungoides and variants Sezary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RECURRENT MYCOSIS FUNGOIDES RECURRENT SEZARY SYNDROME REFRACTORY MYCOSIS FUNGOIDES REFRACTORY SEZARY SYNDROME STAGE IB MYCOSIS FUNGOIDES AND SEZARY SYNDROME AJCC V8 STAGE IIA MYCOSIS FUNGOIDES AND SEZARY SYNDROME AJCC V8 STAGE IIB MYCOSIS FUNGOIDES AND SEZARY SYNDROME AJCC V8 STAGE III MYCOSIS FUNGOIDES AND SEZARY SYNDROME AJCC V8 STAGE IV MYCOSIS FUNGOIDES AND SEZARY SYNDROME AJCC V8

Contacts and locations

Locations

Brigham and Women's Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02115, United States
City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States
Emory University Hospital/Winship Cancer Institute
NOT_YET_RECRUITING

Atlanta, Georgia, 30322, United States
Fred Hutchinson Cancer Center
NOT_YET_RECRUITING

Seattle, Washington, 98109, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States
M D Anderson Cancer Center
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Moffitt Cancer Center
NOT_YET_RECRUITING

Tampa, Florida, 33612, United States
Siteman Cancer Center at Washington University
RECRUITING

St Louis, Missouri, 63110, United States
Stanford Cancer Institute Palo Alto
NOT_YET_RECRUITING

Palo Alto, California, 94304, United States
Thomas Jefferson University Hospital
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19107, United States

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