New radiation technique may make stem cell transplants safer for scleroderma patients

NCT ID NCT04380831

Recruiting now Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early study tests whether a precise type of total body radiation (IMRT) combined with chemotherapy can safely prepare the body for a stem cell transplant in people with severe systemic sclerosis (scleroderma). The goal is to reduce radiation exposure to the lungs and kidneys while still controlling the disease. Only 15 participants will be enrolled to check if the approach is feasible and safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cyclophosphamide (chemotherapy) and total body radiation (IMRT) before stem cell transplant
What this could lead to: If it works, this could lead to a safer stem cell transplant method for severe scleroderma, reducing side effects to the lungs and kidneys.
What could go wrong: This is a very early (Phase 1) pilot study with only 15 people, so it is too small to prove effectiveness. The main goal is just to see if the approach is feasible and safe.

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Conditions

The condition(s) this trial relates to.

systemic sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SYSTEMIC SCLERODERMA

Contacts and locations

Locations

City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States

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