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New cancer drug AOH1996 enters first human tests

NCT ID NCT05227326

Recruiting now Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 29, 2026 · Updated 2 times

Summary

This early-stage trial is testing a new drug called AOH1996 in 92 adults with solid tumors (like lung, ovarian, or pancreatic cancer) that have stopped responding to standard treatments. The drug works by blocking a protein that cancer cells need to grow. The main goals are to find the safest dose and see what side effects occur, while also checking if tumors shrink.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
AOH1996 (a drug that blocks a protein cancer cells need to grow)
What this could lead to
If it works, this could point toward a new treatment option for people with solid tumors that haven't responded to other therapies.
What could go wrong
This is a very early Phase 1 trial focused on safety and dosing, so it's unknown if AOH1996 will effectively shrink tumors. Side effects are possible and being closely monitored.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

leiomyosarcoma malignant pancreatic neoplasm non-small cell lung carcinoma osteosarcoma ovarian cancer pancreatic neoplasm refractory malignant neoplasm synovial sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEIOMYOSARCOMAS NON-SMALL CELL LUNG CANCER OSTEOSARCOMA OVARIAN CANCER PANCREATIC CANCER REFRACTORY MALIGNANT SOLID NEOPLASM SYNOVIAL SARCOMAS

Contacts and locations

Locations

  • City of Hope Medical Center

    RECRUITING

    Duarte, California, 91010, United States

    Contact Email: •••••@•••••

  • City of Hope at Long Beach Elm

    RECRUITING

    Long Beach, California, 90813, United States

  • Honor Health Research and Innovation Institute

    NOT_YET_RECRUITING

    Scottsdale, Arizona, 85258, United States

    Contact Email: •••••@•••••

More trials for these conditions

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