Misted chemotherapy shows promise for advanced stomach cancer in early trial
NCT ID NCT06675136
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial is testing a new method of delivering chemotherapy directly into the abdomen as a fine mist under pressure (PIPAC) for people with stomach cancer that has spread to the lining of the belly. The study combines this misted chemotherapy (nab-paclitaxel) with standard second-line drugs given through a vein. The main goals are to find the safest dose and see if the combination is tolerable. About 30 participants who have already tried one line of treatment will be enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nab-paclitaxel (a form of chemotherapy) given as a pressurized mist into the abdomen, plus paclitaxel and ramucirumab (another chemotherapy and an antibody) given through a vein
- What this could lead to
- If this works, it could offer a new treatment option for stomach cancer that has spread to the lining of the belly, potentially slowing the disease.
- What could go wrong
- This is a very early (Phase 1) trial with only 30 people, so the main goal is safety, not effectiveness. The combination may cause serious side effects or not work better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
City of Hope Medical Center
RECRUITINGDuarte, California, 91010, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Triple chemo cocktail aims to clear deadly bowel blockages in advanced stomach cancer
- Chemotherapy sprayed directly into the abdomen: a new attack on stubborn cancers
- Home monitoring may keep cancer patients out of the ER
- New drug cocktail shows promise for tough stomach cancers
- New radiation technique targets stomach and ovarian cancer spread without surgery
- Aerosol chemo spray shows promise for Hard-to-Treat ovarian cancer