METASTATIC GASTRIC ADENOCARCINOMA

This study is testing if a stomach cancer drug called tislelizumab works just as well when given as a simple injection under the skin, compared to the standard method of a slow infusion into a vein. It will involve about 351 adults with advanced stomach cancer who have not yet re…

This large, late-stage trial is testing which of two chemotherapy combinations works better for people with advanced stomach or esophageal cancer that has spread and cannot be removed by surgery. About 382 participants will be randomly assigned to receive either the standard two-…

This study is for people with advanced stomach or esophageal cancer that has worsened after initial treatment. It tests if adding an immunotherapy drug called nivolumab to the standard two-drug chemotherapy helps control the cancer better and helps patients live longer. About 224…

This study is testing a new combination of five different treatments for people with advanced stomach or esophageal cancer that has worsened after one prior therapy. The goal is to see if this multi-drug approach can better control the cancer. The treatment includes two immunothe…

This study is testing a new oral drug called zongertinib for adults with advanced HER2-positive cancers that have spread and stopped responding to prior treatments. The main goals are to find the safest and most effective dose of zongertinib when given alone or combined with othe…

This early-stage study is testing whether combining two existing drugs, pembrolizumab and lenvatinib, can help control advanced stomach or gastroesophageal cancers that have spread or cannot be surgically removed. The trial is for adults whose cancer has continued to grow despite…

This study is testing whether adding a new drug called ivonescimab to standard chemotherapy helps shrink tumors better in people with advanced stomach or esophageal cancer. It will enroll 88 adults whose cancer has spread or cannot be removed by surgery. The main goal is to see i…

This study is testing a new, personalized vaccine designed to target the unique proteins on a patient's own cancer cells. It is being given alongside an existing immunotherapy drug (pembrolizumab) to see if the combination is safe and can help control advanced solid tumors that h…

This early-stage trial is testing a new way to deliver chemotherapy for advanced stomach cancer that has spread to the abdominal lining. Researchers are combining a standard second-line treatment with a new method that sprays chemotherapy as a fine mist directly into the abdomen …