City Of Hope Medical Center

This early-stage trial tested the safety and best dose of two drugs (enasidenib and cobimetinib) given together to people whose acute myeloid leukemia (AML) had returned or stopped responding to treatment. Only patients with specific gene mutations (IDH2 and RAS) were included. T…

This early-phase study tested a combination of three drugs—regorafenib, nivolumab, and ipilimumab—in 39 people with advanced colorectal cancer that had spread and was no longer responding to chemotherapy. The goal was to find the safest dose and see if the combination could slow …

This early-phase study tested two drugs, pevonedistat and decitabine, together in 12 people with high-risk acute myeloid leukemia (AML). The main goal was to find the safest dose and understand side effects. Researchers also looked at whether the combination could help control th…

This study tested whether adding the drug itacitinib to standard medications (tacrolimus and sirolimus) could help prevent graft-versus-host disease (GVHD) in 59 people with blood cancers like leukemia or myelodysplastic syndrome who received a donor stem cell transplant. GVHD oc…

This study tested a treatment for people with HIV who also have lymphoma (a type of blood cancer). It used very strong chemotherapy drugs followed by a stem cell transplant using the patient's own stem cells. The goal was to see if this approach is safe and possible for this grou…

This study tested a new way to prepare people with hard-to-treat acute leukemia for a donor stem cell transplant. It combined a precise type of radiation (IMRT) with two chemotherapy drugs (etoposide and cytoxan) to kill cancer cells and help the body accept the donor cells. The …

This study tested a strong chemotherapy regimen followed by a stem cell transplant for people with stage IIIB inflammatory breast cancer. The goal was to see if this approach could improve how long patients live without the cancer coming back. 41 patients took part in this phase …

This early study tested whether transplanting insulin-making cells (islets) could help people with type 1 diabetes who already had a kidney transplant and were on anti-rejection drugs. Only 3 people took part. The goal was to see if the procedure was safe and could reduce or stop…

This study tested a treatment for adults with acute myeloid leukemia (AML) who were in their first remission. Patients received high-dose chemotherapy and radiation, followed by a transplant of their own stem cells, plus an immune-boosting drug to help prevent relapse. The goal w…

This early-stage trial tested the safety and best dose of flotetuzumab, a lab-made antibody, in 13 people with advanced blood cancers that had come back or stopped responding to treatment. The goal was to see if the drug could help control the disease by blocking cancer cell grow…

This small pilot study tested whether an 8-week home exercise program guided by a trainer over video calls is practical and helpful for lymphoma survivors. The goal was to see if this approach could improve heart health in survivors who face a higher risk of cardiovascular proble…

This study looked at whether a blood test can detect a type of liver cancer called intrahepatic cholangiocarcinoma (ICC). Researchers measured tiny particles (exosomal miRNAs) in the blood of 535 adults to see if they could accurately identify cancer. The goal is to offer a non-i…

This study looked at whether a blood test can tell if bile duct cancer has spread to nearby lymph nodes before surgery. Researchers tested blood samples from 230 patients with intrahepatic cholangiocarcinoma. The goal is to help doctors choose the best treatment without needing i…

This study looked at whether a blood test that measures tiny particles called exosomes can find early liver metastasis in people with pancreatic cancer before they have surgery. The test checks for specific genetic material in the blood to identify patients at high risk of hidden…

This study tested whether a blood test that looks at tiny particles called exosomes can help find hidden cancer spread in people with a type of bile duct cancer (intrahepatic cholangiocarcinoma). The goal was to see if the test could predict which patients already have cancer cel…

This study looked at whether using at-home monitoring devices (like a wristband pedometer, scale, and blood pressure cuff) can help improve care for cancer patients after they leave the hospital following surgery. 22 people with different cancers took part. The goal was to see if…

This study looked at 109 people to understand how genetics and social factors like income, education, and environment might increase the risk of lung cancer. Researchers compared lung cancer patients and never-smokers to find clues that could help catch the disease earlier. The s…

This study tested a new blood test that looks for tiny bits of cancer DNA left behind after surgery in people with stage II or III colorectal cancer. The goal was to see if the test could find patients at high risk of the cancer coming back, so they could get the right follow-up …

This study looked at how the relationship, or 'therapeutic alliance,' between Latino patients with advanced cancer and their oncologists affects care. Researchers interviewed doctors and held group discussions with patients to understand what helps or hurts this bond, and how bei…