New blood test could spot hidden liver cancer early

NCT ID NCT07225452

Completed Diagnosis Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study tested a new blood test that looks for tiny particles called exosomal microRNAs to detect intrahepatic cholangiocarcinoma, a rare and aggressive liver cancer. Researchers analyzed blood samples from 535 adults to see how accurately the test could identify cancer cases. The goal is to provide a non-invasive way to catch this cancer earlier, when treatment may be more effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Liquid biopsy (blood test measuring exosomal microRNA)
What this could lead to: If successful, this blood test could help doctors detect a hard-to-find liver cancer earlier and more accurately, potentially improving treatment options.
What could go wrong: This is a completed study, but the test is still experimental and not yet available for routine use. It may not be accurate enough for all patients or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cholangiocarcinoma Cirrhosis, Familial, with Pulmonary Hypertension intrahepatic cholangiocarcinoma Liver Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRAHEPATIC CHOLANGIOCARCINOMA (ICC)

Contacts and locations

Locations

City of Hope Medical Center

Duarte, California, 91016, United States

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