City Of Hope Medical Center

This early-stage study is testing the safety and best doses of two new immunotherapy drugs, given alone or combined with standard chemotherapy, for people with advanced colorectal cancer that has spread. The goal is to see if these combinations can help the body's immune system f…

This is a very early, small safety study to see if a new cell therapy is safe and possible to make for people recently diagnosed with Type 1 diabetes. Researchers will take a patient's own immune cells, modify them in a lab to potentially stop the attack on insulin-producing cell…

This study is testing a new way to deliver chemotherapy for advanced appendix or colorectal cancer that has spread to the abdominal lining and cannot be removed by surgery. It compares a new, minimally invasive method that sprays chemotherapy as a pressurized mist directly into t…

This study is testing a two-part treatment for advanced kidney cancer that has spread and continued to grow after standard immunotherapy. The treatment combines a modified cold sore virus (RP2), injected directly into tumors to kill cancer cells and alert the immune system, with …

This study is testing if adding a specific probiotic (CBM588) to a standard immunotherapy drug (pembrolizumab) can better prevent kidney cancer from coming back after surgery. The trial will involve 62 patients who have had surgery for high-risk kidney cancer. Researchers believe…

This study is testing a combination of immunotherapy and chemotherapy for frail adults newly diagnosed with Hodgkin lymphoma who are not healthy enough for the usual first-line treatment. The goal is to see if this alternative approach can safely and effectively control the cance…

This study aims to improve treatment for advanced non-small cell lung cancer by using blood tests to guide immunotherapy decisions. Researchers will track tumor DNA in the blood to determine when to continue, stop, or switch treatments. The goal is to develop personalized approac…

This study tests whether taking duvelisib pills can help prevent cancer from returning in patients with peripheral T-cell lymphoma who have achieved remission after initial chemotherapy. The trial is for patients who have responded well to first treatment but cannot or choose not…

This early-phase study is testing whether a combination of three drugs is safe and effective for adults with a type of blood cancer called B-cell acute lymphoblastic leukemia (ALL) that has come back or hasn't responded to previous treatments. The trial will enroll about 26 parti…

This early-stage trial aims to find a safe and effective dose of a drug called ruxolitinib when given alongside standard chemotherapy (CHOP) for adults newly diagnosed with a rare type of T-cell lymphoma. The main goal is to see if the combination is safe and tolerable. If patien…

This study is testing a new combination of drugs for adults with an aggressive type of lymphoma (DLBCL) that has returned or not responded to prior treatment. The goal is to see if this therapy can effectively shrink the cancer and prepare patients for a stem cell transplant, a p…

This study is testing if a new immunotherapy drug called ivonescimab can shrink tumors in patients with high-risk kidney cancer that hasn't spread. The drug is given by IV for about 3 months before the patient's standard surgery to remove the kidney. Researchers want to see if th…

This study is testing whether a personalized health check for older adults can help manage the side effects of head and neck cancer treatment. It will compare this detailed approach to standard care for 36 patients aged 60+ and their family caregivers. The goal is to see if the p…

This study aims to understand why some patients develop chronic graft-versus-host disease after a stem cell transplant. Researchers will collect blood, saliva, and stool samples from 75 participants to track immune cell changes over time. The goal is to identify patterns that cou…

This study aims to understand if the amount of exercise people do is connected to how long they live. Researchers will analyze existing health data from over 150,000 adults aged 55 to 74. They will look at people's self-reported exercise habits and track mortality rates over time…