City Of Hope Medical Center

This study tests a new method called PIPAC, which delivers chemotherapy as a pressurized mist directly into the abdomen during a small surgery. It is for people with appendix or colorectal cancer that has spread to the belly lining and cannot be removed. The trial compares PIPAC …

This study tests a new way to prepare older patients (50 and older) with leukemia or MDS that has not responded to treatment for a stem cell transplant. Instead of full-body radiation, they receive targeted radiation to the bone marrow and lymph nodes, plus two chemotherapy drugs…

This early-stage study tests whether specially engineered immune cells (CD6-CAR Tregs) are safe and feasible for 6 adults with stage 3 type 1 diabetes. The cells are designed to calm the immune attack on insulin-producing cells, but the goal is disease control, not a cure. Partic…

This study tests a new treatment for advanced kidney cancer that has spread and worsened after immunotherapy. The treatment combines a modified cold sore virus (RP2) that attacks tumor cells and activates the immune system, with a targeted drug (tivozanib) that blocks tumor growt…

This study tests a combination of three drugs (acalabrutinib, venetoclax, and tafasitamab) in 35 adults with previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The goal is to see if the combo is safe and can achieve a complete response with undetecta…

This study tests a new combination of two drugs, golcadomide and rituximab, in people with mantle cell lymphoma that has returned or stopped responding to treatment. The goal is to find the safest dose and see how well the combination works. About 58 adults will take part in this…

This early-phase trial tests whether adding the targeted drug ruxolitinib to standard chemotherapy (CHOP) is safe and effective for people with untreated nodal T-follicular helper (TFH) cell lymphoma, a rare blood cancer. About 20 adults will take part to find the best dose and w…

This study tests a drug called ivonescimab given before surgery for high-risk kidney cancer that hasn't spread. The drug helps the immune system attack cancer and may also block blood vessel growth to tumors. About 31 people will take part to see if the drug shrinks tumors and ho…

This study tests whether the drug duvelisib can help keep peripheral T-cell lymphoma from returning after initial therapy has made it disappear. About 25 adults with certain types of this rare lymphoma will take duvelisib as a maintenance treatment. The goal is to see if it exten…

This early-phase study tests two experimental immunotherapy drugs (ivonescimab and ADG126) alone or with chemotherapy in 30 adults with advanced or metastatic microsatellite stable (MSS) colorectal cancer. The main goal is to find safe doses and check for side effects. This type …

This study is testing if adding a specific probiotic (CBM588) to a standard immunotherapy drug (pembrolizumab) can better prevent kidney cancer from coming back after surgery. The trial will enroll 62 patients who have had surgery for high-risk kidney cancer. Researchers believe …

This study will analyze data from 19,000 healthy adults aged 55-74 to see if exercise is linked to living longer. Researchers will compare people who exercise with those who don't, using information from a past cancer screening trial. The goal is to understand how physical activi…

This early-stage study tests whether a special report, created from a patient's tumor tissue, can help doctors choose better treatments for advanced hormone receptor-positive breast cancer that has spread or cannot be removed by surgery. The report lists which drugs might work an…

This study looks at how immune cells change in the blood and affected tissues of people who develop chronic graft-versus-host disease after a stem cell transplant. Researchers will measure different types of T cells, B cells, and macrophages to find patterns linked to the disease…