Cold sore virus modified to fight kidney cancer in new trial

NCT ID NCT07218692

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 29 times

Summary

This study tests a new treatment for advanced kidney cancer that has spread and worsened after immunotherapy. The treatment combines a modified cold sore virus (RP2) that attacks tumor cells and activates the immune system, with a targeted drug (tivozanib) that blocks tumor growth and blood vessel formation. The trial aims to see if this combination is safe and effective for 35 adults whose cancer has not responded to standard immunotherapy.

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Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

    Contact Email: •••••@•••••

    Contact

  • City of Hope at Irvine Lennar

    Irvine, California, 92618, United States

    Contact Email: •••••@•••••

    Contact

Conditions

Explore the condition pages connected to this study.