City Of Hope Medical Center

This study tests a vaccine designed to protect people who have had a stem cell transplant from a common virus called CMV. The virus can cause serious illness in those with weak immune systems. The vaccine uses a harmless virus to teach the body to fight CMV, aiming to reduce infe…

This study tests a vaccine called Triplex to prevent cytomegalovirus (CMV) infection in adults who have received a stem cell transplant. CMV can cause serious illness in people with weakened immune systems. The vaccine uses harmless pieces of CMV DNA to help the body build immuni…

This study tests whether giving two chemotherapy drugs, clofarabine and melphalan, before a donor stem cell transplant can help prevent leukemia or myelodysplasia from coming back. The trial includes 72 adults whose cancer is in remission or who have high-risk myelodysplastic syn…

This study tested a two-drug chemotherapy combination (carboplatin and nab-paclitaxel) given before surgery to people with locally advanced or inflammatory triple negative breast cancer. The goal was to shrink tumors enough so that no cancer remains at the time of surgery (called…

This study tests a combination of three drugs (botensilimab, balstilimab, and regorafenib) in people with a type of advanced colorectal cancer that has not responded to prior chemotherapy. The goal is to see if this mix can shrink tumors or slow the cancer's growth. About 28 adul…

This early-phase study is for people with a specific kind of advanced lung cancer (ALK-positive non-small cell lung cancer) that has gotten worse despite prior ALK-targeted therapy. The trial combines two drugs: brigatinib (which blocks cancer growth signals) and bevacizumab (whi…

This early-phase study tests a combination of two treatments for glioblastoma that has returned or not responded to standard therapy. The approach uses specially engineered immune cells (CAR T cells) designed to attack the tumor, along with drugs that boost the immune system's ab…

This study tests a new treatment for people with high-risk B-cell non-Hodgkin lymphoma that has come back after initial therapy. Participants first receive a stem cell transplant, then get an infusion of their own immune cells that have been genetically modified to recognize and …

This early-stage study tests whether a patient's own blood stem cells, modified to resist HIV, can be safely infused after a mild chemotherapy-like conditioning. The goal is to see if the modified cells can take hold and help control the virus without lifelong daily medication. T…

This study tested two different chemotherapy regimens given before surgery to shrink tumors in people with stage II or III breast cancer. One group received a standard three-drug combo (TAC), while the other received two different combos in sequence (ACAC), with some also getting…

This early-phase trial tests a new type of immune cell therapy (CAR T cells) designed to target and kill glioblastoma, an aggressive brain cancer that has returned or worsened. The therapy uses a special targeting domain (chlorotoxin) to seek out cancer cells. The study involves …

This early-phase study tests whether specially engineered immune cells (CAR T cells) can safely target and destroy brain tumor cells that have spread to the lining of the brain and spinal cord. Ten adults with glioblastoma, ependymoma, or medulloblastoma will receive these cells.…

This study tested a combination of three treatments for men with prostate cancer that had spread to a few spots in the body. The treatments included a radioactive drug that targets bone tumors, hormone therapy to lower testosterone, and precise radiation to kill cancer cells. The…

This study tests whether combining two drugs, cabozantinib and temozolomide, can help people with advanced soft tissue sarcoma that cannot be removed by surgery or has spread. About 96 adults with leiomyosarcoma or other similar sarcomas will take part. The goal is to see if the …

This early-stage study tests whether a drug called plerixafor can safely collect enough stem cells from people with sickle cell disease for a future gene therapy. Five participants will receive up to two injections of plerixafor. The goal is to see if this method is safe and work…

This early-stage trial tests whether drinking milk from goats genetically modified to produce a human enzyme (lysozyme) can help prevent graft-versus-host disease (GVHD) in people with blood cancer receiving a donor stem cell transplant. About 53 participants will drink a daily a…

This early-stage study tests a new treatment for people with certain B-cell blood cancers (like lymphomas and leukemias) that have come back. The treatment involves taking a patient's own white blood cells, adding a new gene to help them find and kill cancer cells, and giving the…

This early-stage trial tests whether adding regorafenib to the standard venetoclax plus azacitidine regimen is safe and effective for adults with acute myeloid leukemia (AML) that has returned or not responded to prior treatment. About 20 participants will receive the combination…

This study tested a combination of the immunotherapy drug nivolumab and chemotherapy (ICE) in 78 people with Hodgkin lymphoma that returned or didn't respond to initial treatment. The goal was to see if this approach could shrink tumors enough to allow a stem cell transplant. The…

This early-phase study tests a new treatment for metastatic triple negative breast cancer, a type that has spread and is hard to treat. The therapy uses a specially designed virus injected directly into tumors to infect and break them down. The main goal is to find the safest dos…

This early-stage study tests a high-precision radiation technique called stereotactic body radiation therapy (SBRT) in 26 men whose prostate cancer has returned after surgery. The main goal is to find the safest and most effective dose by monitoring side effects. The approach tar…

This early-phase trial tested a combination of two drugs (IRX-2 and nivolumab) plus a low dose of chemotherapy in 8 adults with advanced liver cancer that had returned or spread. The goal was to find the best dose and check for side effects. The approach aims to help the immune s…

This study tests whether a combination of two drugs, lenvatinib and pembrolizumab, can help keep advanced pancreatic cancer from getting worse in people whose cancer cannot be removed by surgery. About 28 adults who have already responded to initial treatment will receive these d…

This study tests a combination of two drugs, tafasitamab and zanubrutinib, in people newly diagnosed with CLL or SLL. The goal is to see if this combination can kill more cancer cells than either drug alone. About 26 adults will take part, and researchers will measure how many ac…

This early-phase study tests a new vaccine made from a person's own immune cells and a small piece of insulin protein. The goal is to see if it is safe and possible to teach the immune system to stop destroying the pancreas cells that make insulin. Six adults with type 1 diabetes…

This phase 2 trial tests whether leflunomide, a drug that calms the immune system, can delay the start of multiple myeloma in people with high-risk smoldering multiple myeloma. The study includes 27 African-American and European-American participants. Researchers are tracking how…

This early-stage study tests a new treatment for people with advanced colorectal or other cancers that make a protein called CEA. The treatment, Ac225-DOTA-M5A, is an antibody that seeks out CEA on cancer cells and delivers a radioactive payload to kill them. The main goals are t…

This early-phase study tests the safety and best dose of adding minnelide to the standard drug osimertinib for people with advanced non-small cell lung cancer that has an EGFR mutation. The goal is to see if the combination can better control tumor growth. About 8 adults with adv…

This early-phase study tests a probiotic called CBM588 in 36 people who have had a donor stem cell transplant for blood cancers. The goal is to see if it is safe and can improve gut bacteria diversity, which may help prevent severe diarrhea and other gut problems. Participants ta…

This early-stage trial tests a new treatment called CD6-CAR Tregs for people with chronic graft-versus-host disease (cGVHD), a complication after a stem cell transplant. The therapy uses specially modified immune cells to calm the overactive immune response that causes cGVHD. The…

This early-stage study tests a new drug called AOH1996 in 12 adults with acute myeloid leukemia (AML) that has come back or not responded to standard treatments. The main goal is to find a safe dose and check for side effects. AOH1996 works by blocking a protein that helps cancer…

This early-phase study tested a vaccine (p53MVA) plus the drug pembrolizumab in 11 adults with advanced solid tumors that had stopped responding to other treatments. The goal was to see if the combination is safe and can boost the immune system to attack cancer cells. Participant…

This early-stage trial tests a combination of chemotherapy (FOLFOX), a blood-vessel blocker (bevacizumab), and two immunotherapy drugs (botensilimab and balstilimab) in 20 people with a type of advanced colorectal cancer called MSS that has spread. The goal is to see if this mix …

This early-stage trial tests whether adding gene therapy to standard chemotherapy can help people with AIDS-related lymphoma fight both cancer and HIV. Ten participants receive chemotherapy followed by an infusion of their own blood stem cells modified with anti-HIV genes. The ma…

This early-phase trial tests leflunomide, an anti-inflammatory drug, in patients with high-risk smoldering multiple myeloma. The goal is to see if it can delay progression to active myeloma. Only one person enrolled, so results are very limited.

This study tests whether adding pterostilbene (an antioxidant from blueberries) to the hormone drug megestrol acetate works better than the drug alone in treating endometrial cancer or precancerous changes. About 44 participants take the drug with or without the supplement before…

This study tests a treatment plan for people with esophageal cancer that hasn't spread. Before surgery, patients receive chemotherapy, radiation, and two immunotherapy drugs (pembrolizumab and lenvatinib) to shrink tumors and boost the immune system's attack on cancer. The goal i…

This study tests whether giving duvelisib on an irregular schedule can control chronic lymphocytic leukemia or small lymphocytic lymphoma as well as standard dosing, but with fewer severe side effects. Fifteen adults with cancer that returned or didn't respond to prior treatment …

This early-stage trial tests the safety of giving multiple doses of neural stem cells that carry a cancer-killing virus directly into the brain of people with recurrent glioblastoma, a severe brain cancer. The stem cells are designed to seek out tumor cells and release the virus …

This early-phase trial tests a new way to prepare the body for a stem cell transplant in people with sickle cell disease. Instead of full-body radiation, doctors use targeted radiation to the bone marrow and lymph nodes along with a drug called alemtuzumab. The goal is to reduce …

This study tests whether the drug daratumumab, given after a stem cell transplant, can help keep multiple myeloma from coming back. About 31 participants will receive daratumumab as a follow-up treatment. The goal is to see if it improves how long people live without their cancer…

This study tests a new type of stem cell transplant for people with severe sickle cell disease who don't have a fully matched donor. It uses a half-matched family donor and a milder chemotherapy to prepare the body, along with removing certain immune cells from the donor cells to…

This early-stage trial tests a new drug, 8-chloro-adenosine, combined with venetoclax in 30 adults whose acute myeloid leukemia has returned or not responded to prior therapy. The main goal is to find the safest dose and check for side effects. The study is currently on hold.

This early-phase trial tests adding camu camu, a prebiotic fruit, to standard immunotherapy (nivolumab and ipilimumab) for people with advanced kidney cancer that has spread. The main goal is to find the safest dose and see how it affects gut bacteria. About 31 participants will …

This early-stage study tests a new way to prepare the body for a donor stem cell transplant in people with high-risk leukemia or myelodysplastic syndrome (MDS). It combines targeted radiation (TMLI) with two chemotherapy drugs to kill cancer cells and make room for healthy donor …

This study tests whether combining two drugs—lenalidomide and epcoritamab—can better control follicular lymphoma that hasn't been treated yet. Follicular lymphoma is not curable, but this combination aims to boost the immune system to kill cancer cells more effectively. About 29 …

This early-phase study tests a new way to prepare adults with acute myeloid leukemia (AML) for a donor stem cell transplant. Instead of full-body radiation, it uses targeted radiation to the bone marrow and lymph nodes, followed by a drug called cyclophosphamide to help prevent g…

This study tests a once-daily radiation schedule over five days for women with low-risk, hormone-sensitive breast cancer. The goal is to see if this shorter treatment keeps the breast looking good while still controlling the cancer. About 48 women aged 40 and older with early-sta…

This early-phase study tests a new immune therapy for people with high-risk or returning non-Hodgkin lymphoma. After a stem cell transplant, patients receive specially modified T-cells designed to find and attack cancer cells. The main goal is to check safety and find the best do…

This study tests a drug called acalabrutinib for people with chronic lymphocytic leukemia (CLL) who also have a type of anemia where the immune system attacks red blood cells. The goal is to see if the drug can control the anemia after other treatments have failed. Only 4 people …

This early-phase study tests whether adding a gut bacteria supplement (CBM588) to standard cancer drugs (nivolumab and cabozantinib) can improve treatment for advanced kidney cancer. About 31 adults with metastatic kidney cancer will take the supplement alongside their regular th…

This study tests whether two immunotherapy drugs, nivolumab and brentuximab vedotin, can help prevent Hodgkin lymphoma from coming back after a stem cell transplant. It includes 62 people with high-risk lymphoma that had returned or didn't respond to earlier treatment. The goal i…

This early-stage trial tests two drugs, copanlisib and venetoclax, in adults with mantle cell lymphoma that has returned or stopped responding to prior treatments. The goal is to find the safest dose and see how well the combination shrinks tumors. Only 8 participants were enroll…

This study looks at a modified approach to prevent and treat cytomegalovirus (CMV) infection in people who have had a donor stem cell transplant for blood cancers or disorders. About 153 participants are involved, and the goal is to see if changing when and how anti-CMV drugs are…

This study tests a drug called durvalumab, given alone or with lenalidomide, in people with T-cell lymphoma that returned or didn't respond to prior treatments. The goal is to find the best dose, check safety, and see if the combination shrinks tumors. About 38 adults with certai…

This study tested whether adding an immunotherapy drug (pembrolizumab) to standard hormone therapy (letrozole) and a targeted drug (palbociclib) could shrink tumors in postmenopausal women with newly diagnosed stage IV estrogen receptor-positive breast cancer. The 47 participants…

This early-phase study tests a precise radiation method (IMRT) to deliver total body irradiation while reducing the dose to the lungs. The goal is to prevent lung side effects in 20 adults with acute leukemia or myelodysplastic syndrome undergoing a stem cell transplant. Research…

This early-phase study tests the safety and effectiveness of giving heated chemotherapy directly into the abdomen during surgery for advanced or recurrent ovarian, fallopian tube, uterine, or peritoneal cancer. About 40 participants will receive this treatment, with some also get…

This early-phase study tests whether adding the diabetes drug metformin and a specific dietary supplement mix to standard chemotherapy is safe and feasible for people with pancreatic cancer that cannot be removed by surgery. The supplement includes ingredients like curcumin, vita…

This study tested a combination of a targeted drug (brentuximab vedotin) and chemotherapy in 48 people with a rare type of blood cancer called CD30-positive peripheral T-cell lymphoma. The goal was to see how well the treatment shrinks tumors and what side effects occur. Particip…

This study tests whether transplanting insulin-making cells (islets) can help people with type 1 diabetes who struggle with dangerous blood sugar swings. About 17 participants will receive the transplant along with immune-suppressing drugs to prevent rejection. The goal is to red…

This early-stage study tests a new cellular therapy for adults with high-risk acute lymphoblastic leukemia (ALL) that has come back or not responded to treatment. Researchers take a patient's own white blood cells, add a gene to help them recognize and attack cancer cells, and in…

This early-stage study tests whether giving gene therapy after standard chemotherapy is safe for people with AIDS-related non-Hodgkin lymphoma. The gene therapy adds anti-HIV genes to the patient's own blood stem cells, aiming to help the body fight HIV. Only 3 participants were …

This early-phase study tested a combination of two drugs—pembrolizumab (an immunotherapy that helps the immune system attack cancer) and vorinostat (a drug that blocks enzymes cancer cells need to grow)—in 52 adults with certain types of lymphoma that had returned or stopped resp…

This early-stage trial tests a new immune cell therapy for people with recurrent or treatment-resistant malignant glioma, a type of brain cancer. The therapy uses the patient's own T cells, which are modified in the lab to recognize and attack cancer cells. The main goals are to …

This early-phase trial tests a new approach for people with high-grade gliomas that have returned after prior treatment. Genetically modified neural stem cells are placed directly into the brain tumor to make it more sensitive to the chemotherapy drug irinotecan. The main goal is…

This early-phase study tests a new treatment called HER2-CAR T cells for people with HER2-positive cancers that have spread to the brain or its lining. The treatment involves taking the patient's own immune cells, modifying them to recognize and attack HER2-positive cancer cells,…

This study tests whether white button mushroom supplements can lower PSA levels in men with prostate cancer that has returned or is low-risk and not yet treated. About 133 participants take the supplement or follow standard monitoring. The goal is to see if the mushrooms affect P…

This early-phase trial tests a new drug called LB-100 combined with standard chemotherapy and immunotherapy for people with untreated extensive-stage small cell lung cancer. The goal is to find the safest dose and see if the combination helps shrink tumors. Only 3 participants we…

This study tests a new way to deliver radiation before a stem cell transplant for people with leukemia or myelodysplastic syndrome (MDS). Instead of radiating the whole body, the new method (TMLI) targets only the bone marrow and lymph nodes, which may reduce damage to healthy or…

This study tests a new combination of drugs (polatuzumab vedotin plus standard chemotherapy and immunotherapy) as the first treatment after lymphoma returns or doesn't respond. About 41 adults with diffuse large B-cell lymphoma will receive this therapy to see if it can shrink tu…

This early-phase trial tests a new approach for people with aggressive B-cell non-Hodgkin lymphoma that has come back after treatment. After a standard stem cell transplant, patients receive their own immune cells (T cells) that have been genetically modified in a lab to better r…

This early-phase study tests whether giving two immunotherapy drugs (durvalumab and tremelimumab) after a targeted radiation procedure can help people with advanced liver cancer that cannot be surgically removed. The trial includes 25 adults whose cancer has spread within the liv…

This study tests if transplanting insulin-making cells from donors can help people with type 1 diabetes control blood sugar better and possibly stop insulin shots. Participants get anti-rejection drugs to protect the new cells. Up to 10 people will be followed for 5 years to see …

This study tests a new approach for people with leukemia or myelodysplastic syndromes (MDS) who need a donor stem cell transplant. Before the transplant, patients receive a combination of targeted radiation (helical tomotherapy) and two chemotherapy drugs (fludarabine and melphal…

This early-stage trial tests whether a personalized cell therapy (CAR T-cells) can safely prevent relapse in older adults with B-cell acute lymphoblastic leukemia who are already in first remission. About 18 participants will receive their own immune cells, modified in a lab to t…

This study tests a new way to do stem cell transplants for people with sickle cell disease. Instead of needing a perfectly matched donor, it uses a half-matched family donor (haploidentical). Before the transplant, patients get two rounds of immune-suppressing therapy to help the…

This early-stage trial was designed to test the safety of a new treatment called STIL101 for people with advanced pancreatic, colorectal, kidney, cervical cancer, or melanoma that has spread or cannot be removed. The treatment uses a patient's own immune cells (T cells) taken fro…

This early-phase study tests a new type of immunotherapy for people with certain leukemias that have come back or not responded to standard treatments. The therapy uses a patient's own or a donor's immune cells that are genetically modified to recognize and attack cancer cells ca…

This early-phase study tests two drugs, pevonedistat and ibrutinib, together in people with chronic lymphocytic leukemia (CLL) or non-Hodgkin lymphoma that has returned or no longer responds to standard therapy. The main goal is to find the safest dose and understand side effects…

This early-phase study tests a new immunotherapy for people with malignant glioma that has returned or not responded to standard treatment. Researchers take a patient's own T-cells (a type of immune cell), add a gene that helps them recognize and attack glioma cells, and infuse t…

This early-phase study tests a combination of two drugs, copanlisib and nivolumab, in people with Richter's transformation or certain non-Hodgkin lymphomas. The goal is to find the safest dose and see how well the drugs work together. About 27 adults will take part, and the study…

This study tests a new combination of three drugs (navitoclax, venetoclax, and decitabine) in people with acute myeloid leukemia that has returned or stopped responding after prior treatment with venetoclax. The main goal is to find the safest dose and understand side effects. Ab…

This study is testing whether a combination of two drugs, epcoritamab and tazemetostat, is safe and effective for adults with follicular lymphoma that has come back or not responded to prior therapy. The drugs work together to help the immune system attack cancer cells and block …

This study tests whether a special PET scan using copper Cu64-DOTA-trastuzumab can predict how well HER2-positive breast cancer responds to targeted therapy (trastuzumab and pertuzumab) before surgery. About 18 women with locally advanced breast cancer will receive the scan and t…

This small pilot study tested whether a special PET scan using a radioactive tracer can predict how well patients with advanced HER2-positive breast cancer respond to the drug ado-trastuzumab emtansine (T-DM1). Ten women with cancer that had spread to other parts of the body rece…

This study compares two types of urine samples—prostatic fluid and post-massage urine—to see which one better predicts whether a prostate biopsy will find cancer. About 243 men scheduled for a prostate biopsy will provide both samples, and researchers will check which sample's ma…

This study is developing a blood test to find colorectal cancer early, even before symptoms start. Researchers will analyze DNA markers in blood samples from 500 people (some with cancer, some healthy) to see if the test can accurately tell who has cancer. The goal is to create a…

This study tests a special PET scan that uses a radioactive tracer to find HER2-positive breast cancer tumors in women with advanced (stage IV) disease. The goal is to see if this scan can better identify which tumors have the HER2 protein, helping doctors plan more targeted trea…

This study tests a special PET scan that uses a radioactive antibody (64Cu-M5A) to find cancers that produce a protein called CEA. About 20 adults with various CEA-positive cancers will receive the injection and have scans over two days. The goal is to see if this method can dete…

This study checks if portable, easy-to-use devices can detect early signs of heart damage in childhood cancer survivors. About 149 people who finished cancer treatment will use these devices at home and in the clinic. The goal is to see if these tools are as accurate as standard …

This study looks at whether taking omega-3 fatty acid supplements (like fish oil) can help prevent breast cancer from returning in women who have already been treated. Eighty women with a specific type of breast cancer (hormone receptor negative) will take either a low or high do…

This study tests whether a free, culturally tailored program called Eat, Move, Live (EML) can help people in underserved communities lower their risk for cancer and other chronic diseases like diabetes. The program includes nutrition education, physical activity sessions, and pra…

This early-phase trial tests whether vaccinating stem cell donors against cytomegalovirus (CMV) can help protect the transplant recipient from CMV infection. About 34 people with blood cancers receiving a donor stem cell transplant will have their donors vaccinated before donatio…

This study compares two over-the-counter creams, Aquaphor and Miaderm, to see which one better treats the painful skin rash caused by radiation therapy in breast cancer patients. About 208 women receiving radiation after breast cancer surgery will use one of the creams and report…

This study tests a telehealth self-management program for people who have finished treatment for early-stage lung or colorectal cancer. The program coaches survivors on follow-up care, communication with doctors, and managing their health. Researchers want to see if it improves c…

This study looks at whether breathing in lavender aromatherapy oil can help cancer patients feel less pain and anxiety during a bone marrow biopsy. About 45 adults with cancer who are nervous about the procedure will try the oil or a placebo. The goal is to find a simple, drug-fr…

This study looks at whether training parents in specific skills can improve learning and school functioning for Latino children with acute leukemia or lymphoma. About 214 families will take part, with some parents receiving a high-intensity program and others getting standard sup…

This study looks at whether curcumin, the ingredient in turmeric, can reduce joint pain in breast cancer survivors caused by aromatase inhibitor drugs. 42 postmenopausal women will take either curcumin or placebo capsules for 3 months. The goal is to see if curcumin improves pain…

This study tests an online program called Day by Day to help women with stage III or IV gynecologic cancer manage fears about their cancer growing or coming back. About 23 women will use the program and report how helpful it is. The goal is to see if the program is easy to use an…

This study tests whether a telehealth program that provides diet support can help people who had surgery for stomach or esophagus cancer improve their nutrition and quality of life. About 53 adults who recently started eating again after surgery will take part in video sessions. …

This study tests a nurse-led multimedia program that helps lung cancer patients and their family caregivers get ready for surgery. The program aims to improve recovery, reduce caregiver burden, and boost quality of life. About 380 people (patients and their caregivers) are taking…

This study looks at whether a special light treatment (photobiomodulation) can help reduce mouth sores, pain, taste changes, and dry mouth in patients receiving a stem cell transplant. Six adult patients with blood or solid tumor cancers are being studied. The goal is to see if t…

This study tests a nurse-led program designed to help people with advanced lung or gynecologic cancer cope with fears about their future. The program teaches practical ways to manage worry and unhelpful thoughts. The study includes 42 participants and focuses on whether the progr…

This small study tests whether using a mindfulness app can help people with metastatic kidney cancer cope better with their disease. About 21 patients will use the app and report on their anxiety, depression, and quality of life. The goal is to see if this approach is practical a…

This study tests whether listening to music during a bone marrow biopsy or aspiration can lower anxiety. About 113 adults with blood cancers will be randomly assigned to either receive standard care or also listen to music during the procedure. Researchers will measure anxiety le…

This study looks at whether a special recovery plan helps people with stomach cancer feel better and leave the hospital sooner after surgery. About 52 patients with early to advanced stomach cancer will take part. The plan aims to reduce pain and nausea, help the bowels work soon…

This study looks at whether whole body MRI scans and liquid biopsies (blood tests) are acceptable and useful for finding early cancer in 100 people aged 50 or older who have a strong family history of cancer. Participants will have these tests and answer questions about their exp…

This study looks at how combining breast MRI scans with tissue samples can help predict a woman's risk of developing breast cancer. Researchers are studying healthy women at high risk to find early signs of aggressive cancers. The goal is to improve risk assessment and catch canc…

This study tests whether a new PET-CT scanner can produce clear images of prostate cancer tumors, similar to the standard scan. About 34 adults with prostate cancer will get both scans to compare. If the new scanner works well, it could allow doctors to plan radiation therapy usi…

This study looks at whether a blood test that finds tiny bits of tumor DNA can help doctors know if early-stage breast cancer patients still have cancer cells after treatment. About 350 people with stage I-III breast cancer will give blood samples and tumor tissue. The goal is to…

This study follows 238 breast cancer patients to see how chemotherapy impacts their physical function, health, and quality of life over time. Researchers compare women aged 65 and older with those under 65, tracking changes from before treatment to six months after. The goal is t…

This study follows 500 people who had early-stage breast cancer (stage 0 to IIIC) to learn about their long-term health, quality of life, and any late side effects from treatment. Researchers will also study blood and tumor samples to understand how the immune system fights cance…

This study looks at whether a team of healthcare professionals can help older adults (65 and older) stay healthy and recover better after a stem cell transplant for blood cancer. About 40 participants will see multiple providers to improve their fitness before and after the trans…

This study looks at whether a special assessment tool can help doctors predict how older patients with cancer will handle chemotherapy. Over 1,000 participants will be evaluated on their thinking, memory, and daily living skills. The goal is to see if this tool can forecast serio…

This study follows 350 stem cell transplant survivors to see how their heart, lungs, and muscles work together over two years. Researchers measure exercise capacity and other health markers to learn why transplant survivors have a higher risk of heart disease. Participants includ…

This study tests whether a social media campaign called 'End Stigma End Fear, End Cervical Cancer' can reduce stigma and encourage Pap tests among 336 disadvantaged women (African descent or Latina, ages 18-70) in California and Trinidad. Researchers will measure changes in stigm…

This study tests whether a special website and video coaching for parents can help children aged 6-12 who were treated for leukemia or lymphoma improve their learning and school performance. Many children survive these cancers but may struggle with memory, attention, and thinking…

This study tests a web-based education tool called HOPE-Genomics that helps cancer patients learn about their genetic test results. About 465 adults with certain cancers (breast, lung, colorectal, and others) will use the tool to see if it improves their understanding of genomics…

This study looks at whether a special PET scan (using Posluma) on the RefleXion X1 machine can spot prostate cancer tumors as well as the standard PET scan. About 20 adults with prostate cancer will get both scans on the same day. The goal is to see if the new scanner can guide r…

This study was designed to see whether getting an IV in the arm that had lymph nodes removed for breast cancer treatment could increase the risk of lymphedema (arm swelling). Researchers planned to use a special dye and camera to watch how fluid moves through the arm's lymph syst…

This study tests a telephone-based counseling program designed for Latinas who may have a higher risk of hereditary breast or ovarian cancer. The goal is to see if this culturally-informed approach helps women feel more in control, less anxious, and better informed about their ca…

This study was designed to see if an online mental health program could help women with advanced gynecologic or breast cancer manage their fear of the cancer returning or getting worse. The program would have been compared to standard educational materials. However, the trial was…

This study tests a mobile app called Oncpatient designed to help cancer patients manage their radiation therapy. Radiation treatment can be confusing, with complex schedules and side effects. The app provides easy-to-access information and guidance. Researchers want to see if pat…

This study collects blood plasma from people who have recovered from COVID-19 to build a bank and analyze the antibodies it contains. Researchers will give this plasma to current COVID-19 patients and track their recovery to see if certain antibody profiles lead to better outcome…

This study looks at whether a survivorship care plan (a personalized health roadmap) can improve quality of life and reduce stress for breast cancer survivors. About 100 women in early survivorship (up to 18 months after treatment) will take part. The goal is to see if having a c…

This study looks at whether a program of exercise and a dietary supplement called nicotinamide riboside (similar to vitamin B3) can improve muscle health and insulin resistance in adults who survived childhood cancer and now have prediabetes. About 20 participants will take part …

This study looks at how to predict serious side effects from chemotherapy in older adults (65+) with early-stage breast cancer. Researchers will use clinical factors and blood tests to build a model that forecasts toxicity. The goal is to help doctors choose safer treatments for …

This study follows 2,500 prostate cancer survivors who had surgery at City of Hope at least one year ago and have no signs of cancer returning. Researchers will track quality of life, sexual health, and long-term complications using surveys and medical records. The goal is to bet…

This study tests a 12-month program to help stem cell transplant survivors find skin cancer early. Survivors are at high risk for skin cancer years after treatment. The program teaches people how to check their own skin and encourages them to tell their doctors about any changes.…

This study uses advanced brain scans to see how chemotherapy changes the brain in women aged 65 and older with early-stage breast cancer. Researchers will compare brain images and thinking tests before and after treatment. The goal is to better understand why some older patients …

This study looks at whether a thorough health review—covering physical, mental, and social well-being—can predict chemotherapy side effects in older adults with solid tumors. Researchers will compare side effects and hospital stays before and after using this assessment. The goal…

This study compares a new PET-CT scanner (RefleXion) to the standard one for people with various cancers. About 20 adults will get both scans to see if the new one finds the same tumors. If it works well, patients may need fewer scans before radiation therapy.

This study looks at whether older adults with cancer can use computer surveys to share their health information. Researchers will test two different computer methods to see which is easier and more reliable. The goal is to make it simpler for doctors to understand and help their …

This study looked at whether using at-home devices (like a thermometer, pulse oximeter, scale, and activity watch) to track health, symptoms, and quality of life after cancer surgery can improve recovery. About 134 adults having major abdominal surgery for digestive system cancer…

This study looks at whether trained peer navigators can help African-American women who finished breast cancer treatment stick to their follow-up care plans. About 145 women will be randomly assigned to get peer support or usual care. The goal is to see if this approach improves …