City Of Hope Medical Center

This early-stage study is testing a new method to safely collect a patient's own blood stem cells, which is a necessary first step for a future gene therapy. The goal of that future therapy is to provide a one-time cure for sickle cell disease. This small pilot study will check i…

This study is testing whether combining two cancer drugs works better than either alone for people newly diagnosed with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The trial will enroll 26 adults who have not yet received treatment for their cancer. Re…

This study is testing whether a new combination of radiation and chemotherapy before a stem cell transplant can help patients with leukemia and related blood disorders. The treatment aims to better prepare the body to accept donor stem cells while reducing complications. Research…

This early-phase study is testing the safety of combining a new cancer vaccine with an existing immunotherapy drug (pembrolizumab) in patients with advanced solid tumors that have spread and stopped responding to standard treatments. The vaccine is designed to train the immune sy…

This early-stage study is testing the safety and effectiveness of a two-step treatment for advanced liver cancer that cannot be surgically removed. First, patients receive a targeted radiation treatment directly to the liver tumor. Then, they receive two immunotherapy drugs desig…

This study is testing whether transplanting insulin-producing islet cells into adults with hard-to-control type 1 diabetes is safe and can help them become less dependent on insulin injections. Participants receive the transplant and must take lifelong anti-rejection drugs to pre…

This early-stage study is testing the safety and feasibility of combining standard chemotherapy drugs with a diabetes medication (metformin) and a specific blend of dietary supplements in patients with advanced pancreatic cancer that cannot be surgically removed. The goal is to s…

This early-stage study is testing the safety and best dose of a new drug, pevonedistat, when given with an existing drug, ibrutinib. It is for adults with chronic lymphocytic leukemia or non-Hodgkin lymphoma that has come back or stopped responding to other treatments. The goal i…

This early-stage study is testing the safety of a new cell therapy for adults with aggressive brain cancers that have spread to the lining of the brain and spinal cord. Doctors take a patient's own immune cells, genetically modify them in a lab to recognize and attack cancer cell…

This study is testing a two-drug chemotherapy regimen followed by a donor stem cell transplant for adults with certain blood cancers that are in remission or at high risk. The goal is to see if this approach can better control the disease and prevent it from coming back after the…

This early-stage study is testing a new, more targeted form of radiation given before a stem cell transplant for patients with acute myeloid leukemia (AML) in remission. The goal is to see if focusing radiation only on the bone marrow and lymph nodes, instead of the whole body, i…

This study is testing a new treatment approach for aggressive types of T-cell lymphoma, a rare blood cancer. It combines a targeted drug that seeks out cancer cells with standard chemotherapy drugs. The goal is to see if this combination is safe and more effective at controlling …

This study is testing whether a personalized survivorship care plan, along with counseling sessions, can help breast cancer survivors manage their health and improve their quality of life after active treatment ends. It compares this approach to just receiving the care plan bookl…

This early-stage study is testing the safety of a new treatment for aggressive brain tumors that have returned. Doctors use specially engineered neural stem cells designed to seek out cancer cells and deliver a virus that kills them. The treatment is given directly into the brain…

This study is testing if giving the drug daratumumab after a patient's own stem cell transplant helps control multiple myeloma for a longer time. It involves 31 patients who have had the transplant. The main goal is to see if this extra treatment can prevent the cancer from progr…

This early-stage study is testing if adding a probiotic called CBM588 to standard cancer drugs (cabozantinib and nivolumab) can help patients with advanced kidney cancer. The probiotic aims to improve the mix of 'good' bacteria in the gut, which might help the body's immune syste…

This early-phase trial is testing a new type of personalized immunotherapy for patients with malignant brain tumors (gliomas) that have returned or stopped responding to standard treatments. Doctors collect a patient's own immune cells (T-cells), genetically modify them in a lab …

This early-stage study is testing whether higher doses of very precise radiation can safely treat prostate cancer that returns after surgery. Researchers are carefully increasing the radiation dose for 26 patients who have had their prostate removed to find the highest amount tha…

This early-stage study is testing whether genetically modified stem cells are safe and can take hold in people with HIV. Researchers collect a patient's own blood stem cells, modify them in a lab to potentially resist HIV, and then return them after mild chemotherapy. The goal is…

This early-stage study aimed to test the safety and early effectiveness of a personalized cell therapy called STIL101. The therapy involved growing a patient's own cancer-fighting immune cells (T-cells) from a tumor sample in a lab and then infusing them back. It was designed for…

This study is testing whether sending patients home with simple devices like a smartwatch, thermometer, and scale after major digestive cancer surgery helps them recover better. The goal is to see if tracking daily health data like steps, weight, and symptoms can help doctors spo…

This is an early-stage safety study for a new type of CAR T-cell therapy designed for adults with a specific type of recurrent brain cancer called glioblastoma. The main goals are to find the safest dose and understand the side effects. Doctors will collect a patient's own immune…

This early-stage study is testing whether adding an experimental drug called minnelide to an existing lung cancer medication (osimertinib) is safe and might help patients whose cancer has continued to grow. The trial is for adults with advanced non-small cell lung cancer that has…

This study is testing whether adding an immunotherapy drug (pembrolizumab) to two standard breast cancer drugs (letrozole and palbociclib) works better for controlling advanced breast cancer. It is for postmenopausal women whose cancer has spread and is fueled by estrogen. The go…

This early-stage study is testing a new type of cellular immunotherapy for adults whose B-cell lymphoma or leukemia has come back. Doctors collect a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer cells, and then infuse them back…

This early-stage study is testing if adding a natural berry supplement called camu camu makes standard immunotherapy drugs work better for people with advanced kidney cancer that has spread. The main goal is to check if the combination is safe and to find the right dose of camu c…

This early-stage study is testing a new gene therapy for people with HIV who also have a type of cancer called non-Hodgkin lymphoma. Doctors collect a patient's own blood stem cells, modify them in a lab to carry genes that may fight HIV, and then return them to the patient after…

This study is testing whether transplanting insulin-producing cells from donors into people with Type 1 diabetes is a safe and effective treatment. The procedure aims to help patients achieve better blood sugar control and potentially become independent from daily insulin injecti…

This early-stage study is testing a combination of two drugs, pembrolizumab and vorinostat, for patients with certain types of lymphoma that have come back or stopped responding to previous treatments. The main goals are to find the safest dose and understand the side effects of …

This study is testing whether a combination of two drugs, epcoritamab and tazemetostat, is safe and effective for adults with follicular lymphoma that has come back or hasn't responded to previous treatments. The goal is to see if this two-drug approach can help control the cance…

This study is testing whether combining two drugs, cabozantinib and temozolomide, can better control advanced soft tissue sarcomas that cannot be removed by surgery or have spread. The trial aims to see if this combination can stop the cancer from growing for longer and improve s…

This early-stage study aims to find the safest and most effective dose of a targeted radiation treatment, given with chemotherapy, to prepare patients for a donor stem cell transplant. It is for people with high-risk forms of acute leukemia or myelodysplastic syndrome who are not…

This study is testing whether giving the cancer drug duvelisib on an irregular schedule works as well as continuous dosing but with fewer severe side effects. It is for adults with chronic lymphocytic leukemia or small lymphocytic lymphoma that has returned or stopped responding …

This early-stage study is testing a two-part treatment for AIDS patients who also have a type of blood cancer called non-Hodgkin lymphoma. First, patients receive standard chemotherapy to fight the cancer. Then, doctors collect the patient's own blood stem cells, modify them in a…

This early-stage study is testing a new way to prepare patients for a stem cell transplant to treat severe sickle cell disease. The goal is to use a more targeted form of radiation to reduce damage to healthy organs and lower the risk of a serious transplant complication. Researc…

This study is testing whether combining two drugs—epcoritamab and lenalidomide—works better than either alone for people with follicular lymphoma who haven't had any prior treatment. The goal is to achieve complete remission and control the disease for as long as possible. About …

This small, early-stage study is testing whether leflunomide, an anti-inflammatory drug used for rheumatoid arthritis, can delay the progression of high-risk smoldering multiple myeloma to active, symptomatic cancer. Researchers are giving the drug daily to a small group of eligi…

This early-stage study is testing whether washing the abdomen with heated chemotherapy during cancer-removal surgery is safe and feasible for patients with advanced or recurrent ovarian, fallopian tube, uterine, or peritoneal cancers. The goal is to see if this approach, sometime…

This study is testing whether a supplement made from white button mushrooms can help control prostate cancer. It is for men whose cancer has returned after initial treatment (shown by rising PSA levels) and for men with low-risk cancer who are being monitored without treatment. R…

This study is testing whether a powerful combination of treatments can shrink or eliminate tumors before surgery for esophageal and gastroesophageal junction cancers. Patients receive standard chemotherapy and radiation alongside an immunotherapy drug (pembrolizumab), followed by…

This early-stage study is testing a new type of stem cell transplant for adults with severe sickle cell disease. It uses a half-matched family donor and a milder chemotherapy regimen to prepare the body, aiming to reduce transplant risks. The main goals are to see if the procedur…

This study is testing a new, more precise way to deliver total body radiation before a stem cell transplant. The goal is to better protect patients' lungs from damage while still effectively treating their blood cancer. It involves 20 patients with acute leukemia or myelodysplast…

This study is testing a new, more targeted form of radiation as a preparatory step before a stem cell transplant. It is for patients with certain types of leukemia or myelodysplastic syndrome who need a transplant but do not have a fully matched donor. The goal is to see if this …

This early-stage trial is testing a new cell therapy for patients with chronic graft-versus-host disease (cGVHD), a serious complication where donor immune cells attack the patient's body after a bone marrow transplant. Researchers modify a donor's immune cells in the lab to crea…

This early-phase study is testing a new type of cell therapy for patients with high-risk or returning B-cell non-Hodgkin lymphoma. After receiving a stem cell transplant, patients get an infusion of their own immune cells that have been genetically modified in a lab to better fin…

This early-stage study is testing a new type of cell therapy for adults with a high-risk or returning form of acute lymphoblastic leukemia (ALL). Doctors take a patient's own immune cells, modify them in a lab to better target cancer, and infuse them back after a short course of …

This small pilot study is testing whether a simple home exercise program, with or without a vitamin B3-like supplement, is a practical way to help adult survivors of childhood cancer who have prediabetes. The goal is to see if this approach can improve muscle health and how the b…

This study is testing whether adding a natural antioxidant found in blueberries, called pterostilbene, to a standard hormone therapy (megestrol acetate) can better slow the growth of endometrial cancer. It involves 44 patients who are already scheduled for a hysterectomy. The goa…

This early-stage study is testing a new drug, LB-100, to see if it makes standard chemotherapy and immunotherapy work better against extensive-stage small cell lung cancer. The main goals are to find the safest and most effective dose of LB-100 and to check for side effects when …

This early-phase study is testing the safety and best dose of a personalized immune cell therapy for adults with recurrent or treatment-resistant malignant brain tumors (glioma). Doctors collect a patient's own immune cells, genetically modify them in a lab to recognize and attac…

This early-stage study is testing the safety and best dose of a new three-drug combination for adults with acute myeloid leukemia (AML) or related blood cancers that have come back or not responded to prior treatments. The goal is to see if adding the drug regorafenib to two exis…

This study is testing whether a team of different healthcare specialists can help older adults with blood cancer prepare for and recover from a stem cell transplant. The team includes doctors, therapists, a dietitian, and a social worker who work with patients for three months be…

This study is testing a two-part treatment for Hodgkin lymphoma that has come back or stopped responding to initial therapy. It combines an immunotherapy drug (nivolumab) that helps the immune system fight cancer with a standard chemotherapy regimen. The goal is to control the ca…

This early-stage study is testing a new type of cellular therapy for adults with acute myeloid leukemia or a related blood cancer that has come back or not responded to standard treatments. Doctors collect a patient's or donor's immune cells, genetically modify them in a lab to b…

This study is testing a shorter, more convenient radiation schedule for women with early-stage, low-risk breast cancer. It aims to see if giving radiation once a day for five days in a row works as well as the standard every-other-day schedule, with a focus on maintaining a good …

This study is testing two different combinations of chemotherapy drugs, given before surgery, to see which is better at shrinking breast tumors. For some patients, a targeted drug called trastuzumab (Herceptin) is added to one of the combinations. The goal is to reduce the amount…

This study is testing a personalized plan to manage cytomegalovirus (CMV), a common and potentially serious infection, in patients who have received a donor stem cell transplant for blood cancers or disorders. The plan involves closely monitoring the virus level and the patient's…

This study is testing a new combination of four drugs for people with a common type of advanced colorectal cancer that has spread. The goal is to find the safest and most effective dose and see if this four-drug approach can help control the cancer. It combines standard chemother…

This study is testing whether the drug leflunomide can delay or prevent smoldering multiple myeloma from progressing to active cancer. It involves 27 African-American and European-American adults with high-risk smoldering myeloma who take a daily pill. The main goal is to see if …

This is an early-stage study to find the safest dose of two cancer drugs, copanlisib and nivolumab, when given together. It is for adults with aggressive blood cancers that have transformed from slower-growing types, like Richter's syndrome. The main goal is to see how well patie…

This early-stage study is testing the safety of a new two-part treatment for aggressive brain tumors that have returned after standard therapy. Doctors place genetically modified stem cells directly into the brain during surgery, hoping these cells will make the tumor more sensit…

This early-phase study is testing a combination of two drugs, brigatinib and bevacizumab, for patients with a specific type of advanced lung cancer (ALK-positive) that has worsened despite prior targeted therapy. The main goals are to find the safest dose and understand the side …

This early-stage study is testing the safety of a personalized vaccine for adults recently diagnosed with type 1 diabetes. The vaccine is made from a patient's own immune cells and a piece of a pancreas protein. The goal is to teach the immune system to stop attacking the body's …

This study tests whether taking a daily pill called enasidenib can help prevent acute myeloid leukemia (AML) from coming back after a patient receives a stem cell transplant from a donor. The pill is designed to block a specific enzyme that helps cancer cells grow. The trial invo…

This study is testing two drugs, durvalumab and lenalidomide, to see if they can help control advanced T-cell lymphomas that have come back or stopped responding to other treatments. It aims to find the safest dose and see how well the drugs work, either alone or together, for pa…

This study is testing a new combination of drugs for people with an aggressive type of lymphoma that has returned or not responded to the first treatment. The treatment combines a targeted antibody-drug with standard chemotherapy and immunotherapy. The goal is to see if this comb…

This trial is testing a new combination of three drugs for people with a common type of advanced colon cancer that has spread and is no longer responding to standard chemotherapy. The goal is to see if two immunotherapy drugs that help the immune system attack cancer, combined wi…

This is a first-in-human, early-stage safety study testing a new type of cancer treatment called an oncolytic virus. The virus, called CF33-hNIS-antiPDL1, is designed to be injected directly into tumors to infect and break down cancer cells, while also potentially helping the pat…

This early-phase study is testing the safety and best dose of a two-drug combination (enasidenib and cobimetinib) for adults with acute myeloid leukemia (AML) that has come back or stopped responding to other treatments. The drugs work by blocking specific signals that help the c…

This study is testing whether portable heart monitoring devices used at home can detect early heart problems in childhood cancer survivors as accurately as standard clinic tests. Researchers are comparing two portable systems against echocardiograms and MRI scans to see if home m…

This study is developing a new blood test to detect colorectal cancer early. Researchers are analyzing DNA from blood samples of 500 people, including those with cancer and healthy controls, to find patterns that signal the disease. The goal is to create a less invasive screening…

This study is testing a new type of imaging machine for men with prostate cancer. Researchers want to see if the pictures it takes are as good as the current standard scan. If successful, this machine could allow doctors to plan a patient's radiation therapy using the same scan, …

This study is testing a special PET scan to see if it can predict how well a patient's HER2-positive breast cancer will respond to two targeted drugs (trastuzumab and pertuzumab) given before surgery. Researchers will give 18 patients with locally advanced breast cancer a scan us…

This study aims to find which of two urine collection methods better predicts prostate cancer biopsy results. Researchers are comparing expressed prostatic secretion (collected after prostate massage) with post-massage urine in 243 men undergoing prostate biopsies. The goal is to…

This is a small, early-stage study to test a new type of imaging scan. The scan uses a special radioactive tracer that attaches to a protein (CEA) made by many cancers. The goal is to see if this new scan can find cancer spots that standard imaging tests might miss in patients wi…

This study tested a new type of PET scan to see if it could better show where and how much HER2-positive breast cancer has spread in the body. It involved 18 women whose cancer had spread beyond the original tumor site. The goal was to see if this special scan could help doctors …

This study tests whether sending educational text messages to stem cell transplant survivors, and sometimes training their doctors, helps them find skin cancer sooner. Survivors are at high risk for skin cancer, and finding it early leads to better outcomes. The research compares…

This study is testing a new approach to prevent a common and dangerous viral infection called CMV in people receiving a stem cell transplant for blood cancer. Researchers are giving a vaccine to the healthy stem cell donors before the transplant. The goal is to see if the donor's…

This study is testing if a drug called ruxolitinib can prevent a serious complication called chronic graft-versus-host disease (GVHD) in patients who have received a bone marrow transplant for blood cancer. Researchers will first use a blood test to identify patients at high risk…

This study tests whether a free 12-week program of nutrition education, cooking demonstrations, and exercise sessions can help reduce the risk of cancer and chronic diseases like diabetes. The program is designed specifically for underserved communities and is offered in English …

This study is testing a vaccine designed to prevent cytomegalovirus (CMV) infection in adults with blood cancers who are receiving a half-matched stem cell transplant. CMV is a common virus that can become life-threatening when the immune system is weakened after transplant. The …

This study is testing a special recovery plan for patients having surgery for stomach cancer. The plan aims to help patients feel better faster by reducing pain and nausea, helping their digestive system work again, and shortening their hospital stay. Researchers are following 52…

This study aimed to test an online mental health program designed to help women with advanced breast or gynecologic cancers manage their fear of the cancer coming back or getting worse. Participants would have been randomly assigned to either the main program, which taught coping…

This study is testing whether an online coaching program for parents can help children who have survived leukemia or lymphoma do better in school. Many kids face learning and memory challenges after cancer treatment. Researchers are comparing this special website and video coachi…

This study is testing whether a mindfulness app is a practical tool to help people with advanced kidney cancer that has spread. It aims to see if using the app for 20-30 minutes a day, at least 4 days a week for 4 weeks, can help reduce anxiety, fear of the cancer returning, and …

This study aims to find out if one common skin cream works better than another at treating or preventing painful skin rashes caused by radiation therapy for breast cancer. About 208 patients will be randomly assigned to use either Aquaphor ointment or Miaderm cream on their skin …

This study is testing whether a special program led by nurses can help people with advanced lung or gynecologic cancer cope with intense fears about their illness getting worse. Participants will have five short video sessions over six weeks to learn worry management skills, set …

This study looks at whether a special light therapy can help reduce painful mouth sores and other oral problems in cancer patients receiving stem cell transplants. Researchers will observe 6 adult patients and their nurses to see how well the therapy works at controlling symptoms…

This study tests whether a special parenting skills program helps Latino children who have survived leukemia or lymphoma do better in school. Researchers are comparing an intensive 8-session training for parents against a standard single-session meeting to see which improves chil…

This small pilot study is testing whether curcumin, the active ingredient in turmeric, can reduce joint pain in breast cancer survivors. The pain is a common side effect of essential hormone-blocking medications. Forty-two participants will take either the curcumin supplement or …

This study tested a multimedia support program designed to help patients with early to mid-stage lung cancer and their family caregivers prepare for surgery. The program included videos, a handbook, and nurse coaching before and after the operation. Researchers wanted to see if t…

This study is testing a new mobile phone app designed to help cancer patients during radiation therapy. The app provides education and guidance on managing treatment side effects and logistics. Researchers want to see if patients find the app easy to use and helpful. The study in…

This study is testing a telehealth program designed to help people who have finished treatment for early-stage lung or colorectal cancer. It compares a special coaching program that teaches self-management skills to standard educational materials. The goal is to see if the coachi…

This study is testing whether a telehealth diet coaching program helps people eat better and feel better after surgery for stomach or esophageal cancer. About 53 participants were randomly assigned to receive either four virtual coaching sessions or standard nutritional support. …

This study is testing a new online program designed to help women with advanced gynecologic cancer manage their fear of the cancer getting worse or coming back. The program, called 'Day by Day,' teaches skills to handle anxiety and refocus thoughts. It is being tested with a smal…

This study is testing whether smelling lavender or similar scents can help reduce pain and anxiety for cancer patients during bone marrow biopsy procedures. Researchers want to see if this simple, drug-free approach can make these uncomfortable tests easier to tolerate. The trial…

This study is testing whether listening to music can help reduce anxiety for people undergoing a bone marrow biopsy or aspiration, which are common but often stressful procedures for blood cancer patients. About 113 adults with blood conditions will be randomly assigned to either…

This study aims to create a tool to help doctors predict which older adults with breast cancer are most at risk for severe side effects from chemotherapy. Researchers will study 700 participants to identify health factors and blood markers linked to these risks. The goal is to he…

This study uses advanced brain MRI scans to understand how chemotherapy affects the brain in older women with breast cancer. Researchers will scan 49 women before and after chemotherapy to look for changes in brain structure and function. The goal is to find brain scan patterns t…

This study examines blood plasma from people who recovered from COVID-19 to understand their antibody levels and properties. Researchers are creating a plasma bank and analyzing whether specific antibody profiles in donated plasma correlate with better recovery outcomes in severe…

This study follows 500 breast cancer survivors for years after their treatment ends to understand their long-term health and quality of life. Researchers collect feedback through questionnaires and samples to learn about complications, immune responses, and what makes recovery mo…

This study is testing whether people find it acceptable to use a full-body MRI scan and a special blood test (liquid biopsy) to try to detect cancer early. It involves 100 adults with a strong family history of cancer. The main goal is to see if people are comfortable with this a…

This study aims to understand why people who survive a blood cancer transplant have a higher risk of heart disease. Researchers will closely monitor 350 adult patients' heart, lung, and muscle function before their transplant and for two years after. The goal is to learn how thes…

This study aimed to see if placing an IV line and giving fluids in the arm of breast cancer survivors at risk for lymphedema (chronic arm swelling) is safe and does not damage the lymphatic system. Researchers planned to use a special fluorescent dye and imaging to track fluid fl…

This study tested a special phone counseling program designed for Latina women at high risk for hereditary breast or ovarian cancer. The goal was to see if this culturally-informed counseling could help women better understand their risk, reduce anxiety, and feel more in control.…

This study is looking at how high and low doses of omega-3 fish oil supplements affect breast tissue in women who have had a certain type of breast cancer. Researchers are testing 80 survivors to find biological signs that omega-3s might help prevent cancer from coming back. The …

This study is testing a new type of PET-CT scanner called the RefleXion system. Researchers want to see if its images are as good as standard PET-CT scans at finding cancer spots in patients with various tumors. The goal is to learn if this new system could one day allow doctors …

This small study is testing a new type of PET scan to see if it can predict which patients with advanced HER2-positive breast cancer will benefit from a specific drug treatment. Researchers attach a tiny radioactive tag to a cancer drug and use a scanner to see where it goes in t…

This study is testing a blood test that looks for tiny pieces of leftover cancer DNA after treatment for early-stage breast cancer. The goal is to see if this test can identify patients who still have hidden cancer cells and might benefit from additional therapy. Researchers will…

This study is testing a web-based education tool called HOPE-Genomics to see if it helps cancer patients better understand their personal genetic test results and general cancer genomics. Researchers are comparing the tool's effectiveness against standard education methods in abo…

This study tracks the long-term health of prostate cancer survivors who had surgery at least one year ago. Researchers follow 2500 men to understand their quality of life, potential complications, and overall health after treatment. The information gathered will help improve futu…