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New combo therapy aims to delay return of spread prostate cancer

NCT ID NCT00544830

Ongoing Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether adding targeted radiation to standard hormone therapy can better control prostate cancer that has spread to a few spots in the body. About 29 men with hormone-sensitive prostate cancer and up to 5 metastases will receive hormone therapy (bicalutamide, goserelin, or leuprolide) plus intensity-modulated radiation therapy. The main goal is to see how long it takes for PSA levels to rise again, which would signal the cancer is returning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
hormone therapy (bicalutamide, goserelin, or leuprolide) and intensity-modulated radiation therapy
What this could lead to
If successful, this approach could help control prostate cancer that has spread to a few places, potentially delaying the need for more aggressive treatment.
What could go wrong
This is a small, early-phase trial with only 29 participants, so results may not apply to everyone. Hormone therapy can cause side effects like hot flashes and fatigue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma prostate adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSA LEVEL GREATER THAN TWO STAGE IV PROSTATE ADENOCARCINOMA AJCC V7

Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

  • City of Hope South Pasadena

    South Pasadena, California, 91030, United States

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