Engineered immune cells target brain tumors in new trial

NCT ID NCT03696030

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-stage trial tests a treatment called HER2-CAR T cells for people with HER2-positive cancers that have spread to the brain or its lining. The cells are given directly into the brain's fluid spaces to try to kill tumor cells. The main goals are to find the safest dose and understand side effects. About 24 adults with recurrent brain or spinal lining metastases will take part.

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Conditions

The condition(s) this trial relates to.

brain cancer breast cancer breast neoplasm cancer HER2 positive breast carcinoma Meningeal Carcinomatosis metastatic malignant neoplasm in the brain neoplasm neoplastic meningitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States