New Half-Matched transplant offers hope for sickle cell patients

NCT ID NCT03249831

First seen Mar 09, 2026 · Last updated Apr 30, 2026 · Updated 5 times

Summary

This early-phase study tests a new type of stem cell transplant for people with severe sickle cell disease who don't have a fully matched donor. It uses a half-matched relative's stem cells, a gentle chemotherapy prep, and removes certain immune cells to reduce side effects. The goal is to see if this approach is safe and can create a mix of donor and patient blood cells, potentially controlling the disease.

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Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

Conditions

Explore the condition pages connected to this study.