Immunotherapy combo aims to stop hodgkin lymphoma relapse after transplant

NCT ID NCT03057795

Ongoing Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing whether two immunotherapy drugs, nivolumab and brentuximab vedotin, can prevent Hodgkin lymphoma from coming back after a stem cell transplant. The study includes 62 patients with high-risk Hodgkin lymphoma that had returned or not responded to prior treatment. The main goal is to see how many patients remain cancer-free 18 months after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nivolumab and brentuximab vedotin
What this could lead to: If successful, this combination could help prevent Hodgkin lymphoma from returning after a stem cell transplant, improving long-term survival.
What could go wrong: This is a small, early-phase trial with only 62 participants, so results may not apply to all patients. The drugs can cause immune-related side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

classic Hodgkin lymphoma Hodgkins lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLASSIC HODGKIN LYMPHOMA RECURRENT HODGKIN LYMPHOMA REFRACTORY HODGKIN LYMPHOMA

Contacts and locations

Locations

City of Hope Medical Center

Duarte, California, 91010, United States
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
M D Anderson Cancer Center

Houston, Texas, 77030, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

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