Could a common mushroom help fight prostate cancer?

NCT ID NCT04519879

Terminated Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This phase 2 trial tests whether white button mushroom extract can lower PSA levels in men with prostate cancer that has returned after treatment or is low-risk and not yet treated. About 133 men will take the supplement or be observed. The goal is to see if the mushroom affects PSA, immune function, and hormone levels tied to cancer growth.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: White button mushroom extract
What this could lead to: If it works, this could offer a natural supplement to help manage prostate cancer by lowering PSA levels and possibly slowing progression.
What could go wrong: This is a small, early-phase trial that is currently suspended. The supplement may not lower PSA or affect cancer growth, and side effects are not yet well understood.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

prostate adenocarcinoma prostate cancer prostate carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE ADENOCARCINOMA PSA FAILURE PSA PROGRESSION RECURRENT PROSTATE CARCINOMA STAGE I PROSTATE CANCER AJCC V8 STAGE IIA PROSTATE CANCER AJCC V8 STAGE IIB PROSTATE CANCER AJCC V8 STAGE IIC PROSTATE CANCER AJCC V8 STAGE IIIA PROSTATE CANCER AJCC V8 STAGE IIIC PROSTATE CANCER AJCC V8

Contacts and locations

Locations

City of Hope Medical Center

Duarte, California, 91010, United States
City of Hope Rancho Cucamonga

Rancho Cucamonga, California, 91730, United States
City of Hope South Pasadena

South Pasadena, California, 91030, United States
City of Hope West Covina

West Covina, California, 91790, United States
City of Hope at Glendora

Glendora, California, 91741, United States
City of Hope at Irvine Lennar

Irvine, California, 92618, United States
John Wayne Cancer Institute

Santa Monica, California, 90404, United States

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