Could a common mushroom help fight prostate cancer?
NCT ID NCT04519879
First seen Nov 01, 2025 · Last updated Jun 19, 2026 · Updated 31 times
Summary
This phase 2 trial tests whether white button mushroom extract can lower PSA levels in men with prostate cancer that has returned after treatment or is low-risk and not yet treated. About 133 men will take the supplement or be observed. The goal is to see if the mushroom affects PSA, immune function, and hormone levels tied to cancer growth.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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City of Hope Medical Center
Duarte, California, 91010, United States
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City of Hope Rancho Cucamonga
Rancho Cucamonga, California, 91730, United States
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City of Hope South Pasadena
South Pasadena, California, 91030, United States
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City of Hope West Covina
West Covina, California, 91790, United States
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City of Hope at Glendora
Glendora, California, 91741, United States
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City of Hope at Irvine Lennar
Irvine, California, 92618, United States
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John Wayne Cancer Institute
Santa Monica, California, 90404, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
White button mushroom extract
What this could lead to
If it works, this could offer a natural supplement to help manage prostate cancer by lowering PSA levels and possibly slowing progression.
What could go wrong
This is a small, early-phase trial that is currently suspended. The supplement may not lower PSA or affect cancer growth, and side effects are not yet well understood.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.