Engineered immune cells take aim at returning blood cancers

NCT ID NCT02153580

First seen Nov 01, 2025 · Last updated Jun 15, 2026 · Updated 39 times

Summary

This early-stage study tests a personalized cell therapy for adults with certain B-cell blood cancers (like lymphomas and leukemias) that have come back after prior treatment. Doctors take a patient's own white blood cells, modify them in the lab to better recognize and attack cancer cells, and give them back after a short course of chemotherapy. The main goals are to check safety and find the best dose, while also seeing how long the modified cells last in the body and whether they shrink tumors.

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Contacts and locations

Locations

  • City of Hope Comprehensive Cancer Center

    Duarte, California, 91010, United States

Conditions

Explore the condition pages connected to this study.