Could a One-Time immune cell infusion help older leukemia patients avoid harsh chemo?
NCT ID NCT05707273
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests a personalized cell therapy for adults aged 60 and older with B-cell acute lymphoblastic leukemia (ALL) who are in first remission. Researchers take a patient's own immune cells, modify them in the lab to recognize and attack leukemia cells, and infuse them back. The goal is to see if this approach is safe and feasible as a consolidation treatment, potentially offering a gentler alternative to standard chemotherapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CD19-CAR T cells (a patient's own immune cells modified to attack cancer)
What this could lead to
If it works, this could offer a less toxic treatment option for older adults with leukemia, potentially reducing the need for intensive chemotherapy.
What could go wrong
This is a very early (phase 1) and small (18 participants) trial focused on safety and dosing. CAR T-cell therapy can cause serious side effects like cytokine release syndrome. It may not work for everyone.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Medical Center
Duarte, California, 91010, United States