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Could a cancer drug tame a blood disorder?

NCT ID NCT04657094

Ongoing Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests the drug acalabrutinib in people with chronic lymphocytic leukemia (CLL) who also have a blood condition called autoimmune hemolytic anemia (AIHA) that has come back or not responded to treatment. The study aims to see if acalabrutinib can control the anemia by blocking certain enzymes. Only 4 participants were enrolled, making this a very early look at the drug's potential.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
acalabrutinib
What this could lead to
If successful, this could offer a new treatment option for patients with autoimmune hemolytic anemia that hasn't responded to standard therapy.
What could go wrong
This is a very small early-phase trial (only 4 participants), so results may not apply to larger groups. The drug may not work or could have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autoimmune hemolytic anemia autoimmune hemolytic anemia, warm type B-cell chronic lymphocytic leukemia chronic lymphocytic leukemia/small lymphocytic lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE HEMOLYTIC ANEMIA CHRONIC LYMPHOCYTIC LEUKEMIA CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA WARM ANTIBODY AUTOIMMUNE HEMOLYTIC ANEMIA

Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.