New cocktail aims to shrink metastatic breast tumors

NCT ID NCT02778685

Ongoing Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase II trial tests whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard hormone therapy (letrozole or fulvestrant) and the targeted drug palbociclib can shrink tumors in postmenopausal women with newly diagnosed stage IV estrogen receptor-positive breast cancer. The study enrolled 47 participants and measures how many patients respond to treatment, as well as any side effects. The goal is to see if this combination can better control cancer that has spread.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pembrolizumab (Keytruda), letrozole (Femara), palbociclib (Ibrance), and fulvestrant (Faslodex)
What this could lead to: If successful, this combination could offer a new treatment option that helps control metastatic ER+ breast cancer for longer.
What could go wrong: This is a small phase II study with only 47 participants, so results may not apply to all patients. Side effects from combining immunotherapy with hormone therapy and a targeted drug are not yet fully known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast carcinoma breast neoplasm estrogen-receptor positive breast cancer invasive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC BREAST CARCINOMA STAGE IV BREAST CANCER AJCC V6 AND V7

Contacts and locations

Locations

City of Hope Antelope Valley

Lancaster, California, 93534, United States
City of Hope Corona

Corona, California, 92879, United States
City of Hope Medical Center

Duarte, California, 91010, United States
City of Hope Mission Hills

Mission Hills, California, 91345, United States
City of Hope South Pasadena

South Pasadena, California, 91030, United States
City of Hope Upland

Upland, California, 91786, United States
City of Hope West Covina

West Covina, California, 91790, United States

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