New Vaccine-Immunotherapy combo targets multiple cancers in early trial
NCT ID NCT02432963
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 1 trial tests a vaccine (p53MVA) that trains the immune system to attack cancer cells with a p53 mutation, given together with the immunotherapy drug pembrolizumab (Keytruda). The study includes 11 people with advanced solid tumors like lung, head and neck, liver, kidney, melanoma, bladder, sarcoma, triple-negative breast, colorectal, and pancreatic cancers that have not responded to prior treatments. The main goal is to check safety and side effects, and to see if the combination can shrink tumors.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- p53MVA vaccine and pembrolizumab (Keytruda)
- What this could lead to
- If it works, this could point toward a new treatment option for several hard-to-treat cancers that have stopped responding to other therapies.
- What could go wrong
- This is a very early, small phase 1 trial with only 11 participants, so safety and effectiveness are not yet proven. The vaccine uses a modified virus, which may cause side effects, and the combination may not work for all cancer types.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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City of Hope Medical Center
Duarte, California, 91010, United States
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