Could a probiotic help stem cell transplant recovery?

NCT ID NCT03922035

Ongoing Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests whether a probiotic called CBM588 is safe and can improve outcomes in 36 patients who have received a donor stem cell transplant. The probiotic aims to increase healthy gut bacteria and reduce gut-related side effects like diarrhea and colon inflammation. The study primarily looks at safety and whether patients can take the probiotic as directed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Clostridium butyricum MIYAIRI 588 (CBM588) probiotic
What this could lead to: If it works, this could point toward a simple probiotic to reduce gut complications and improve recovery after stem cell transplants.
What could go wrong: This is a very small, early-phase pilot study (36 people) focused mainly on safety and feasibility. It is too early to know if the probiotic truly helps, and results may not apply to all transplant patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOPOIETIC AND LYMPHOID CELL NEOPLASM

Contacts and locations

Locations

City of Hope Medical Center

Duarte, California, 91010, United States

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