New drug cocktail shows promise for rare sarcomas
NCT ID NCT04200443
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase II trial tests whether combining cabozantinib (a targeted therapy) with temozolomide (a chemotherapy drug) can slow tumor growth in people with advanced leiomyosarcoma or other soft tissue sarcomas that cannot be surgically removed or have spread. About 96 participants will receive both drugs orally. The main goal is to see how long the cancer stays under control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cabozantinib and temozolomide
- What this could lead to
- If successful, this combination could offer a new treatment option to slow or stop tumor growth in people with advanced soft tissue sarcomas.
- What could go wrong
- This is a mid-stage trial with only 96 participants. The drugs may not work better than existing treatments and can cause side effects like fatigue, nausea, or liver issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
City of Hope Medical Center
Duarte, California, 91010, United States
-
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can an immune-boosting drug make chemotherapy more effective against sarcoma?
- Vitamin c and chemo: new hope for Hard-to-Treat sarcomas?
- New hope for sarcoma patients: drug slows tumor growth in late-stage trial
- Cancer drug shows promise in keeping sarcoma in check
- Lung-Directed chemo spray aims to stop cancer spread
- Immune cells take on sarcoma in early trial