Aggressive chemo combo with stem cell rescue tested for rare breast cancer
NCT ID NCT00003042
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tested a very strong chemotherapy regimen followed by a stem cell transplant in 41 people with stage IIIB inflammatory breast cancer. The goal was to see if this intense approach could help keep the cancer from coming back and improve survival. Participants received several chemotherapy drugs, then had their own stem cells returned to help the body recover.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
chemotherapy (cisplatin, cyclophosphamide, doxorubicin, melphalan, paclitaxel, tamoxifen) plus stem cell transplant
What this could lead to
If successful, this approach could offer a more aggressive treatment option for inflammatory breast cancer, potentially improving relapse-free and overall survival.
What could go wrong
This is a small, completed phase II trial with only 41 participants, so results may not apply broadly. High-dose chemotherapy carries serious risks like infection, organ damage, and treatment-related death.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Comprehensive Cancer Center
Duarte, California, 91010-3000, United States