Radiation before CAR T-Cell therapy: a new hope for tough lymphoma?
NCT ID NCT05800405
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests whether giving radiation to all active cancer spots before CAR T-cell infusion can help control large B-cell lymphoma that has come back or not responded to treatment. Nine adults with relapsed or refractory lymphoma will receive targeted radiation during the wait for their CAR T-cells. The goal is to see if this bridging approach is safe and feasible, potentially improving treatment outcomes with minimal added toxicity.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
external beam radiation therapy
What this could lead to
If successful, this approach could make CAR T-cell therapy more effective for patients with aggressive lymphoma that has returned or not responded to treatment.
What could go wrong
This is a very early, small feasibility study with only 9 participants, so results may not apply broadly. Radiation may cause side effects or fail to improve outcomes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Medical Center
RECRUITINGDuarte, California, 91010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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