Chemotherapy as a fine mist: could PIPAC reduce side effects for abdominal cancer patients?
NCT ID NCT04329494
First seen Jun 25, 2026 · Last updated Jul 23, 2026 · Updated 3 times
Summary
This early-phase trial tests a technique called PIPAC, which turns liquid chemotherapy into a fine mist sprayed directly into the abdomen during a minimally invasive surgery. It aims to see if this approach is safe and causes fewer side effects than standard chemotherapy. The study includes 49 adults with ovarian, uterine, appendiceal, colorectal, or gastric cancer that has spread to the lining of the abdomen.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) with cisplatin, doxorubicin, oxaliplatin, leucovorin, fluorouracil, mitomycin, or irinotecan
- What this could lead to
- If successful, this could provide a less toxic way to deliver chemotherapy directly to abdominal tumors, potentially reducing side effects while controlling cancer spread.
- What could go wrong
- This is an early phase 1 trial with only 49 participants, so safety and effectiveness are not yet proven. The procedure is invasive and may cause complications or not improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
City of Hope Medical Center
RECRUITINGDuarte, California, 91010, United States
-
Mayo Clinic in Florida
ACTIVE_NOT_RECRUITINGJacksonville, Florida, 32224-9980, United States
-
Northwell Health Cancer Institute at Huntington
RECRUITINGGreenlawn, New York, 11740, United States
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