New hope for tough leukemia? early trial of AOH1996 begins
NCT ID NCT06763341
First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 2 times
Summary
This early-stage trial is testing a new drug called AOH1996 in 12 adults with acute myeloid leukemia (AML) that has come back or not responded to standard treatments. The drug works by blocking a protein that helps cancer cells grow and repair themselves. The main goals are to find a safe dose and check for side effects, while also watching for any signs that the drug is helping.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AOH1996 (a PCNA inhibitor drug)
What this could lead to
If it works, this could point toward a new treatment option for patients with AML that has returned or not responded to prior therapies.
What could go wrong
This is a very early Phase 1 trial with only 12 participants, so the main goal is safety, not proof of effectiveness. The drug may not work or could cause unexpected side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Medical Center
Duarte, California, 91010, United States