Blood 'Cleansing' may revive bladder cancer treatment

NCT ID NCT07087860

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a procedure that filters a patient's blood (therapeutic plasma exchange) can help standard cancer drugs work better in people with advanced bladder or urinary tract cancer that has stopped responding to previous treatments. About 70 adults will be randomly assigned to receive either the blood-filtering procedure plus two approved drugs (enfortumab vedotin and pembrolizumab) or the usual next-line therapy. The goal is to see if this combination can shrink tumors or slow cancer growth.

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Conditions

The condition(s) this trial relates to.

bladder transitional cell carcinoma infiltrating bladder urothelial carcinoma renal pelvis/ureter urothelial carcinoma stage IVb bladder cancer ureter cancer Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Mayo Clinic in Rochester

    RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact