Can early plasma exchange save sight and mobility?

NCT ID NCT07100990

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times

Summary

This study tests whether starting plasma exchange early, rather than waiting, leads to better vision in severe optic neuritis and less disability in severe transverse myelitis. About 382 adults with these inflammatory nerve conditions will be randomly assigned to early or rescue plasma exchange. The goal is to see if early treatment improves outcomes like visual sharpness and overall neurological function.

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Conditions

The condition(s) this trial relates to.

acute transverse myelitis myelitis optic neuritis transverse myelitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYELITIS MYELITIS, TRANSVERSE OPTIC NEURITIS

Contacts and locations

Locations

Boston Medical Center
RECRUITING

Boston, Massachusetts, 02118, United States
Columbia University
RECRUITING

New York, New York, 10032, United States
Dean McGee Eye Institute at University of Oklahoma Health Sciences
ACTIVE_NOT_RECRUITING

Oklahoma City, Oklahoma, 73117, United States
Duke University Health System
RECRUITING

Durham, North Carolina, 27710, United States
Harvard University Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21218, United States
Loma Linda University
ACTIVE_NOT_RECRUITING

Loma Linda, California, 92350, United States
Mayo Clinic Arizona
RECRUITING

Scottsdale, Arizona, 85259, United States
Mayo Clinic Florida
RECRUITING

Jacksonville, Florida, 32224, United States
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Medstar Health Research Institute
RECRUITING

Columbia, Maryland, 21044, United States
NYU Langone Health
ACTIVE_NOT_RECRUITING

New York, New York, 10016, United States
Northwestern University
RECRUITING

Evanston, Illinois, 60208, United States
Oregon Health & Sciences University
RECRUITING

Portland, Oregon, 97239, United States
Regents of the University of Michigan
RECRUITING

Ann Arbor, Michigan, 48105, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of California, Davis
RECRUITING

Sacramento, California, 95817, United States
University of Colorado - Anschutz Medical
RECRUITING

Aurora, Colorado, 80045, United States
University of Illinois Chicago
RECRUITING

Chicago, Illinois, 60612, United States
University of Maryland, Baltimore
RECRUITING

Baltimore, Maryland, 21201, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States
University of North Carolina School of Medicine
ACTIVE_NOT_RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Pittsburgh Medical Center, Magee Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Weill Cornell Medical College
RECRUITING

New York, New York, 10065, United States
Yale University School of Medicine
RECRUITING

North Haven, Connecticut, 06510, United States

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