Mayo Clinic

This study tested whether an education program helps low-income, uninsured adults aged 18-45 accept and complete a free HPV vaccine series. The goal is to prevent HPV-related cancers. About 100 participants took part, and researchers tracked how many started and finished the vacc…

This early-stage trial tests whether a single infusion of stem cells from donated fat tissue can safely treat rejection in kidney transplant recipients. The cells are delivered directly into the kidney artery. The study includes 12 adults with biopsy-proven rejection and aims to …

This phase 2 trial tests a new drug called TVB-2640 (denifanstat) combined with trastuzumab and either chemotherapy (paclitaxel) or hormone therapy in 17 people with HER2+ metastatic breast cancer that no longer responds to trastuzumab. TVB-2640 blocks an enzyme cancer cells need…

This phase 2 trial tested the drug obinutuzumab in 20 adults with a kidney disease called primary FSGS. The participants had not responded well to or could not take standard treatments like steroids. The goal was to see if obinutuzumab could reduce protein leakage in the urine, a…

This phase 2 trial tested the immunotherapy drug pembrolizumab (Keytruda) alone or combined with idelalisib or ibrutinib in 65 patients with chronic lymphocytic leukemia (CLL) or low-grade B-cell non-Hodgkin lymphoma (NHL) that had returned or stopped responding to treatment. The…

This study tested a drug called ixazomib, alone or with other medicines, in 165 people whose multiple myeloma (a blood cancer) had come back. The goal was to see if these combinations could shrink or control the cancer. Participants received different treatment plans, and doctors…

This study tested a drug called deucravacitinib in 7 adults with pityriasis rubra pilaris, a rare skin disease that causes red, scaly patches. The goal was to see if the drug safely improves skin symptoms and itching over 24 weeks. Researchers also looked for unique markers in th…

This study tested a combination of two targeted drugs (pertuzumab and trastuzumab) plus a chemotherapy drug (enzalutamide) in 7 men with advanced prostate cancer that had stopped responding to standard treatments. The goal was to see if the combination could shrink or slow the gr…

This early-phase trial tested a combination of two drugs—selinexor and choline salicylate (a type of aspirin)—in 22 adults with certain lymphomas or multiple myeloma that had come back or not responded to treatment. The main goal was to find the safest dose and check for side eff…

This phase II trial tested a shorter course of higher-dose radiation (hypofractionation) in 53 men with high-risk prostate cancer who had already had their prostate removed. The goal was to see if this approach could control cancer while reducing side effects. Participants also r…

This phase II trial tested giving a higher dose of radiation over fewer sessions (hypofractionated radiotherapy) to the whole breast before surgery in 25 women with early-stage breast cancer. The goal was to see if this approach could kill more tumor cells and cause fewer side ef…

This Phase 2 trial tested a combination of targeted drugs (vemurafenib and cobimetinib) and immunotherapy (atezolizumab and tiragolumab) given before surgery to 64 patients with high-risk stage III melanoma. The goal was to see if the treatment could eliminate or shrink the cance…

This early-phase trial tested a three-part treatment for non-Hodgkin lymphoma: freezing tumors (cryoablation), injecting a personalized dendritic cell vaccine made from the patient's own cells, and giving the immunotherapy drug pembrolizumab (Keytruda). The goal was to find the s…

This study tested a drug called daratumumab in 49 people with multiple myeloma who were eligible for a stem cell transplant. The goal was to see if daratumumab could help eliminate any remaining cancer cells in the bone marrow after the transplant. While the treatment aims to con…

This study tested whether it is safe and feasible to perform two heart procedures—MitraClip to repair a leaky mitral valve and Watchman to close off a part of the heart linked to stroke risk—in one session. The trial enrolled 25 adults with both severe mitral regurgitation and at…

This study looked at whether doing cardiac rehab at home, or a mix of home and clinic sessions, works as well as going to the clinic for all sessions. 206 heart patients participated, using a mobile health platform and home exercise. The goal was to see if flexible options could …

This study tested whether the drug sotatercept, given for 36 weeks, improves how the heart and lungs work during exercise in people with pulmonary arterial hypertension (PAH). Thirty adults with PAH received injections of sotatercept. Researchers measured heart pressure, blood fl…

This study compared two treatments for severe fecal incontinence: biofeedback (exercises to strengthen muscles) and injections of a bulking agent into the rectal wall. 275 adults with frequent accidents took part. After a month of basic care, those who didn't improve were randoml…

This early-phase study tested whether a colon-targeted butyrate tablet (BKR-017) could help people with type 1 diabetes improve insulin sensitivity and lower triglycerides. Six adults with type 1 diabetes took the tablets for 28 days alongside their usual care. The goal was to se…

This study from the Mayo Clinic tested a laser procedure called MP-TSCPC in 65 glaucoma patients to see how well it lowers eye pressure. Researchers tracked patients for one year after the procedure, measuring changes in eye pressure, medication use, and vision. The goal was to e…

This early-phase study tested whether combining a topical cream (imiquimod) with an immunotherapy drug (pembrolizumab) is safe and effective for people with advanced melanoma that has spread. Seven participants with stage IIIB to IV melanoma were enrolled. The goal was to see if …

This phase II trial tested the drug alisertib, alone or combined with fulvestrant, in 96 postmenopausal women with advanced breast cancer that no longer responds to hormone therapy. Alisertib blocks enzymes that help cancer cells grow, while fulvestrant blocks estrogen. The goal …

This study tested a virtual world-based cardiac rehabilitation program called 'Destination Cardiac Rehab' against traditional center-based rehab. Over 2,800 adults with heart conditions participated to see if the virtual program could match or beat in-person rehab in improving he…

This study tested a shorter course of proton radiation (5 treatments over 2 weeks) for men with localized prostate cancer, compared to the usual 8 weeks. The goal was to see if this approach maintains quality of life and controls the cancer. 150 men with low- to intermediate-risk…

This study tested the drug ibrutinib in 35 people with chronic lymphocytic leukemia (CLL) who still had small amounts of cancer cells after their first treatment. The goal was to see if ibrutinib could clear those leftover cells from the blood and bone marrow. Participants took i…

This study tested a treatment for people with HPV-related throat cancer. It combined a higher dose of radiation with the chemotherapy drug docetaxel. The goal was to see if this approach could better control the tumor and improve survival. The study involved 81 participants and w…

This completed study tested whether two diabetes medications, sitagliptin and dapagliflozin, are safe and can improve movement and thinking in people with Parkinson's disease or Lewy body dementia. 18 participants took either a drug or a placebo daily for a short time. The goal w…

This pilot study tested whether rimegepant (Nurtec ODT), a drug already used for migraines, could help prevent cluster headaches. Twenty adults with recurrent cluster headaches took the drug every other day for a week. Researchers measured changes in weekly attack frequency and p…

This study tested two different laser treatment locations for open-angle glaucoma: one targeting the nasal side of the eye and one targeting the inferior side. 13 patients received the laser procedure to see which location better lowers eye pressure. The goal is to find the most …

This study tested a new way of using mechanical ventilators, called VentCoach, to better protect the lungs of ICU patients with breathing failure. 18 adults on ventilators were randomly assigned to either the VentCoach protocol or standard care. The main goal was to see if doctor…

This study looked at 261 kidney transplant patients to see if taking a once-daily anti-rejection drug (Envarsus XR) leads to fewer side effects and better medication adherence compared to the standard twice-daily drug. Patients reported symptoms like trembling, muscle cramps, and…

This study tested a new way to treat low-risk prostate cancer using MRI-guided laser ablation. Seven men with early-stage prostate cancer received the treatment to see if it was safe and could successfully destroy tumors. The goal was to target only the cancer while avoiding side…

This study tested whether the drug Entresto (LCZ 696) can improve how the kidneys and heart handle extra salt and fluid in people with type 2 diabetes. Some participants had early signs of heart stiffness (diastolic dysfunction) and others did not. The goal was to see if the drug…

This study looked at how an inhaled drug called treprostinil helps patients with pulmonary hypertension caused by interstitial lung disease. Researchers measured heart function and breathing efficiency during exercise after 3 months of treatment. The goal was to understand how th…

This trial tested different doses of proton beam therapy combined with standard chemotherapy for people with stage 2-3 non-small cell lung cancer that cannot be surgically removed. The goal was to find the best radiation dose to control the cancer. Twenty participants received tr…

This study tested a combination of two drugs, futibatinib and pembrolizumab, in 14 adults with advanced or metastatic liver cancer that had not responded to prior treatment. The goal was to see if the combination could stop or slow cancer growth. The approach uses futibatinib to …

This early-phase trial tested a personalized vaccine made from a patient's own immune cells to see if it is safe for people with advanced ovarian, fallopian tube, or peritoneal cancer. Nineteen participants who had already undergone surgery and chemotherapy received the vaccine. …

This study tested whether combining two endoscopic procedures—Hybrid Argon Plasma Coagulation (HAPC) and Endoscopic Sleeve Gastroplasty (ESG)—is safer and more effective than ESG alone for weight loss. The trial included 45 adults with obesity (BMI 30–40) who had not succeeded wi…

This small study tested whether the drug erenumab (Aimovig) can prevent persistent headaches after a mild traumatic brain injury. Six adults with recent post-traumatic headache were given either erenumab or a placebo. The goal was to see if the drug could reduce the number of mod…

This completed trial enrolled 2,486 people with asymptomatic high-grade carotid stenosis (narrowing of the neck arteries) to see if adding surgery or stenting to intensive medical management reduces stroke risk more than medical management alone. Participants were randomly assign…

This study looked at whether taking simple sugars as a daily supplement can improve health in children with congenital disorders of glycosylation (CDG), a rare genetic condition. Twenty participants took the supplement while researchers tracked growth, blood sugar, liver function…

This study tested two drugs—auranofin (originally for arthritis) and sirolimus (an immune suppressant)—in 29 people with advanced or recurrent lung cancer who had no standard options left. The goal was to find the safest dose and see if the combination could slow cancer growth. T…

This study collects blood, tissue, and urine from about 589 people with different types of kidney or urinary tract tumors, plus healthy volunteers. Researchers are looking for special DNA markers (methylated DNA) that could help detect these cancers earlier and more accurately. T…

This study tested a new type of CT scanner (photon-counting detector CT) to see if it gives clearer images of heart arteries and blood flow compared to standard CT and nuclear stress tests. Researchers enrolled 276 adults with suspected coronary artery disease. The goal was to se…

This study tested a new 3D ultrasound called quantitative transmission imaging (QTI) against standard MRI for breast cancer screening in 26 women at high risk. The goal was to see if QTI could effectively detect suspicious findings. If it works, QTI might offer a faster, less exp…

This study looked at different ways to take tissue samples from the bile duct during a procedure called ERCP. The goal was to see which method is most accurate for finding cancer. 327 adults with unclear bile duct narrowing took part. Researchers compared several biopsy technique…

This study tested whether a computerized stethoscope that uses artificial intelligence (AI) can accurately detect two common heart valve conditions: aortic stenosis and mitral regurgitation. Researchers at Mayo Clinic recorded heart sounds from 400 adults and compared the AI's an…

This study tested a new ultra-low-dose chest CT technique in 3 children (ages 1-17) with hereditary hemorrhagic telangiectasia (HHT) to see if it could detect abnormal blood vessels in the lungs (PAVMs) using much less radiation than standard CT. The goal was to find the lowest p…

This study looked at whether an MRI scan can help doctors diagnose rheumatoid arthritis (RA) sooner in people with joint swelling. 75 adults with early symptoms were given an MRI and followed for a year. The goal was to see if MRI findings could predict who would develop RA, allo…

This study tested a new, noninvasive method called SAVE to help classify breast masses as benign or malignant. Researchers at Mayo Clinic enrolled 266 women with breast lesions to see how well the SAVE method could tell cancerous from non-cancerous masses. The goal is to provide …

This study tested whether a special PET/MR scan using a radioactive tracer called F-18 florbetapir can detect amyloid protein buildup in the nerves of people with amyloidosis. Eight adults with confirmed nerve amyloidosis or other nerve diseases took part. The goal was to see if …

This study looked at over 3,000 women with dense breast tissue to see if adding molecular breast imaging (MBI) to standard digital breast tomosynthesis (DBT) finds more invasive cancers. MBI uses a small amount of radioactive material to highlight active cells, like cancer. The g…

This study tested whether an artificial intelligence (AI) tool could help doctors detect cardiac amyloidosis, a rare but serious heart condition, earlier using standard ECG tests. Over 20,000 patients were involved, with some doctors using the AI-enhanced ECG and others continuin…

This phase 2 trial tested whether a special PET scan using a radioactive tracer called 68Ga-PSMA can better detect advanced liver cancer that has spread. The tracer attaches to a protein found on liver cancer cells, making them visible on the scan. The study involved 29 adults wi…

This study by Mayo Clinic tested whether analyzing chemicals in a person's breath could help diagnose or predict the course of liver disease, liver cancer, and COVID-19. Researchers collected breath samples from 46 participants and looked for unique patterns of volatile organic c…

This study asked 107 people with a history of non-muscle invasive bladder cancer whether they preferred a non-invasive urine test (CxBladder Monitor) or the standard cystoscopy (a thin tube inserted into the bladder) for routine cancer surveillance. Participants tried both method…

This study tested whether women can collect their own vaginal samples to detect HPV, the virus that causes cervical cancer. Researchers compared self-collected swabs to those taken by a doctor in 222 participants. The goal was to see if self-sampling is accurate and acceptable, w…

This study tested whether measuring pulse volume in the leg can help doctors detect active bleeding during an endoscopy for gastrointestinal bleeding. Researchers used a non-invasive pulse flowmeter on 13 adults undergoing emergency endoscopy. The goal was to see if changes in pu…

This pilot study tested whether a portable 6-lead ECG device, paired with an artificial intelligence algorithm, can help screen first-degree relatives of people with dilated cardiomyopathy (a weakened heart muscle). The goal was to see if this mobile approach could detect reduced…

This study tested a special PET/MRI scan that uses a radioactive tracer to find liver cancer cells. The goal was to see if this scan can detect liver cancer earlier and more accurately than standard scans. 52 adults with liver cancer took part, and researchers compared the new sc…

This study tested a new ultrasound-based imaging method called Nonlinear Elasticity Mapping (NEM) to help tell apart benign and cancerous breast lumps. Researchers measured how breast tissue stretches and compresses, looking for patterns that match cancer. 172 women with breast f…

This study tested a new method called global metabolomic profiling to diagnose inborn errors of metabolism, a group of rare genetic disorders. Researchers compared this approach to traditional testing in 240 participants. The goal was to see if the new method could more accuratel…

This study tested whether a simple, non-invasive brain wave test (EEG) can help diagnose Alzheimer's disease at different stages. Researchers collected EEG data from 29 people, including those with mild cognitive impairment, Alzheimer's at various stages, dementia with Lewy bodie…

This study tested whether an artificial intelligence (AI) tool, called ACE 2.0, can detect undiagnosed liver cirrhosis by analyzing a routine electrocardiogram (ECG). Researchers at Mayo Clinic enrolled 279 primary care clinicians and their adult patients. The AI flagged ECGs tha…

This study tested an artificial intelligence (AI) program called DermAI to see if it could accurately interpret photos of skin patch tests for contact dermatitis. Researchers compared the AI's readings to those of human experts. The goal was to make remote allergy testing more pr…

This pilot study tested whether a special PET/CT scan using a radioactive tracer called Ga-68 PSMA-11 can detect treatment response in patients with metastatic adenoid cystic carcinoma, a rare salivary gland cancer. Six adults with this cancer underwent the scan at two time point…

This study looked at 150 female athletes aged 14-24 who had already torn their ACL once. The goal was to find out which movement patterns put them at higher risk for a second ACL tear and to test if special rehab exercises could lower that risk. By identifying high-risk athletes …

This study tested whether using social networks could help Hispanic and Somali immigrants in Minnesota lose weight and lower heart disease risk. About 475 people took part, and researchers tracked weight, waist size, and heart health over 6 to 12 months. The goal was to see if fr…

This study tests whether injecting a concentrated sugar-water solution (dextrose) into the knee joint can reduce pain and improve function in people with knee osteoarthritis. Participants receive either the dextrose injection or a placebo (salt-water injection) under ultrasound g…

This study tests a personalized approach to giving the steroid dexamethasone to hospitalized adults with pneumonia. Instead of a standard dose, the amount is adjusted daily based on a blood marker called C-reactive protein (CRP). The goal is to reduce steroid side effects while s…

This study tested whether adding a steroid called dexamethasone to a standard occipital nerve block (using numbing medicines) provides extra headache relief. 120 adults with various headache types received injections at the back of the head. Researchers tracked changes in headach…

This study tests a 10-week, remotely supervised strength training program for endometrial cancer survivors living in rural or underserved areas. The goal is to see if the program is practical and helps improve physical function and quality of life. Participants exercise twice a w…

This study tested whether a new prosthetic hand, the SoftHand Pro, helps people with below-elbow limb loss perform daily activities better than a commonly used hand, the i-Limb. Thirty-six adults who already use a myoelectric hand took part over 8 weeks. Researchers measured how …

This study tested a combination of non-narcotic pain relievers—ibuprofen, gabapentin, acetaminophen, and methocarbamol—after hip arthroscopy. 86 adults participated to see if this regimen could control pain without using opioids. The goal was to find a safer way to manage post-su…

This pilot study tested whether rimegepant (Nurtec), a drug used for migraines, can reduce chronic abdominal pain in people with irritable bowel syndrome (IBS). Thirty-nine adults with non-constipation IBS took either the drug or a placebo for 28 days. Researchers measured change…

This study looked at 121 patients with blocked bile ducts (biliary obstruction) to see which drainage method—endoscopic (through a scope) or percutaneous (through the skin)—led to a better quality of life. Researchers measured changes in mobility, self-care, pain, and anxiety. Th…

This study tested whether a non-opioid pain drug called suzetrigine can control pain after outpatient facial plastic surgery and reduce the need for opioid pills. 100 adults took part at Mayo Clinic. Researchers measured how many opioid pills were used in the first week and how m…

This study looked at whether video doctor visits (telehealth) work as well as in-person visits for people with brain tumors (gliomas) who are taking oral chemotherapy. 30 patients took part, alternating between telehealth and in-person checkups. The goal was to see which type of …

This pilot study tested whether a non-invasive vagus nerve stimulator can help people with post-COVID syndrome who suffer from fatigue and headaches. Eighteen participants used the device, and researchers measured changes in their functional status and fatigue levels. The goal is…

This study tested whether a 12-week virtual exercise program could help rural cancer survivors improve their physical function and quality of life. One hundred adults who had completed cancer treatment and lived in rural areas took part. The program focused on cardiovascular endu…

This study tested a telephone-based collaborative care program for 516 people with stage III or IV cancer. The program included regular check-ins, personalized exercise plans, and help managing treatment side effects. The goal was to see if it could improve mobility, reduce pain,…

This study tested two different numbing creams to see which one works better for pain during a laser skin treatment. 22 adults with sun-damaged skin tried both creams on different sides of their face. The goal was to find which cream provides better pain relief and fewer side eff…

This pilot study tested whether an injection made from a patient's own blood, called A2MRP, is safe and can help with moderate knee osteoarthritis. Twenty adults with painful knee OA received a single ultrasound-guided injection. Researchers tracked side effects and measured pain…

This study tested whether adding brief advice on the Mediterranean diet and physical activity to standard cognitive behavioral therapy for insomnia (CBT-I) could improve sleep quality. Five adults with chronic insomnia participated. Researchers measured sleep quality and insomnia…

This early study tested whether injecting a special mixture of cells from a person's own belly fat into their arthritic knee is safe and doable. Nine adults with knee osteoarthritis received the injection. The main goal was to check for side effects, not to measure pain relief, s…

This study tested whether the medication PB can safely reduce excessive urination in people with certain kidney diseases, including inherited nephrogenic diabetes insipidus, lithium-induced diabetes insipidus, and polycystic kidney disease treated with tolvaptan. Researchers meas…

This study tested whether using artificial intelligence (machine learning) to plan radiation treatment could reduce side effects for people with head and neck cancer. 204 adults receiving radiation therapy were randomly assigned to either AI-assisted or standard treatment plannin…

This study tested whether a headband called Muse-S, which senses brain activity, could help midlife women with sleep problems like insomnia. Thirty-one women going through menopause wore the device at home. The goal was to see if it was practical and if it improved sleep quality …

This study tested a topical cannabidiol (CBD) cream against a placebo cream to see if it could reduce nerve pain, numbness, and tingling in the hands and feet caused by chemotherapy. Forty adults with moderate to severe chemotherapy-induced peripheral neuropathy (CIPN) applied th…

This study tested whether a very high dose of the diuretic bumetanide can remove more fluid than standard doses of furosemide in people hospitalized with worsening heart failure. Twenty patients received either the ultra-high dose or the usual dose over 24 hours. The goal was to …

This study tested whether giving methadone as a pill before heart surgery works as well as giving it through an IV during anesthesia. 41 adults having planned heart surgery took part. Researchers measured how much extra pain medicine they needed and their pain scores after surger…

This pilot study tested whether people with eosinophilic esophagitis (EoE) triggered by milk can safely eat baked milk. Seven participants ate a baked milk muffin daily for six weeks. Researchers measured if this led to fewer eosinophils (a type of white blood cell) in the esopha…

This pilot study tested whether varenicline, a drug used to help people quit smoking, can change how the rectum senses pressure in people with irritable bowel syndrome (IBS) who have chronic belly pain. Eight adults with IBS (but not the constipation type) took the drug for 8 day…

This study compared two pain medicines given during scheduled C-sections: a spinal injection of morphine or an IV dose of methadone. The goal was to see which approach reduced the need for extra painkillers in the first two days after delivery. Thirty women participated, and rese…

This study tested if weighted blankets can help reduce agitation and other behavioral symptoms in people with dementia. Researchers observed 30 patients in hospital or hospice settings. The goal was to see if a simple, non-drug approach could improve comfort and calmness.

This study tested two different painkillers in 32 women having breast reduction surgery. Each woman received a long-acting painkiller (liposomal bupivacaine) on one breast and a standard painkiller (bupivacaine hydrochloride) on the other. The goal was to see which one provided b…

This study compared two different schedules of proton therapy after mastectomy in 88 women with breast cancer. One group received 15 treatments, the other 25, to see if the shorter course was as safe and effective. The goal was to reduce side effects and treatment burden without …

This study tested whether a nasal spray made from rose geranium in sesame oil can improve symptoms of nasal vestibulitis—like dryness, discomfort, bleeding, and scabbing—in cancer patients receiving chemotherapy. Over 100 participants were randomly assigned to use either the rose…

This small study tested dupilumab (Dupixent), a drug used for allergies and eczema, in 9 adults with moderate to severe chronic itching from liver disease. Participants received injections every 2 weeks for 18 weeks. The goal was to see if itching scores improved. Because it was …

This study tested whether distance Reiki—a hands-off energy therapy—could improve quality of life and immune function in 30 adults with multiple myeloma who had a stem cell transplant. Participants received real Reiki, fake Reiki, or no extra care. The goal was to see if Reiki he…

This study tested whether a home-based pulmonary rehabilitation program with health coaching helps people with COPD stay committed to rehab after leaving the hospital. 296 adults aged 40 and older who were hospitalized for a COPD flare-up took part. The home program used remote t…

This early study tested whether giving mesenchymal stem cells through an IV is safe for people with advanced COPD. Fifteen participants received the treatment, and researchers watched for any immediate side effects. The study did not aim to cure COPD, but to see if this approach …

This large study tested whether a conversation guide and decision support tools, used by healthcare providers, could help patients choose non-drug pain relief methods after surgery. Over 81,000 adults participated. The goal was to see if this approach improves pain, physical func…

This study tested a special water bottle nozzle designed to strengthen mouth and tongue muscles while you drink. 43 adults with mild to moderate sleep apnea used the nozzle daily for 8 weeks. Researchers measured changes in sleep quality, snoring, and apnea severity to see if thi…

This study tested whether a short, calming virtual reality (VR) experience could reduce blood pressure and anxiety in adults with suspected white coat hypertension—where blood pressure spikes due to clinic stress. Seventy-nine participants used a VR headset for 5 minutes during a…

This study tested a special pain program for breast cancer survivors who have joint and muscle pain from taking aromatase inhibitors (hormone therapy). The program combined education, coping skills, and gentle movement to help reduce pain, improve mood, and make it easier to stic…

This study tested a device that gently stimulates a nerve in the neck (called nVNS) to see if it can reduce symptoms like dizziness and fatigue in teenagers with POTS, a condition that causes a rapid heart rate upon standing. Forty teens with newly diagnosed POTS took part at May…

This pilot study tested whether acupressure, a noninvasive technique, can help reduce anxiety in patients receiving chemotherapy. Thirty adults undergoing chemo at Mayo Clinic who reported at least mild anxiety were offered a nurse-led acupressure session and taught how to do it …

This study tested whether a virtual program combining mindfulness and weight management could improve wellbeing in obese cancer survivors. Nineteen adults who had stage I-III cancer and were in remission took part in 12 online sessions. The goal was to see if the program was feas…

This study looked at whether a specific stretch called the sleeper stretch can help CrossFit athletes with shoulder pain move better and perform stronger. Twenty-six regular CrossFit participants were included, and researchers measured their shoulder strength and function. The go…

This study tested whether listening to pre-recorded hypnotherapy sessions on a smartphone or tablet could reduce bloating. Twenty-seven adults with chronic bloating used seven sessions over 12 weeks. Researchers measured changes in bloating severity and quality of life.

This study tested a home-based lifestyle program for people with severe obstructive sleep apnea and severe obesity. The program used a tablet and sensors to track sleep, diet, and exercise, along with regular calls from a health coach. The goal was to see if people could use the …

This study tested a new care model called BeWell360-CG, which provides health and wellness coaching to caregivers of people with advanced lung cancer. The goal was to see if the program could reduce caregiver burden and improve their quality of life. Fifty-five caregivers partici…

This study tested a system that uses electronic health records to help cancer patients track and manage common symptoms like pain, fatigue, anxiety, and sleep problems. Over 50,000 adults with cancer took part. The goal was to see if this approach could improve quality of life an…

This study tested whether ketoconazole, an antifungal drug, can reduce the skin rash caused by EGFR inhibitor cancer therapy. 58 participants with ongoing rash were given either ketoconazole or a placebo. The main goal was to see if the drug improved rash symptoms and quality of …

This study tested whether critically ill patients on breathing machines could safely manage their own sedation using a button-controlled device. 161 adults in the ICU were randomly assigned to either self-manage their sedation or have it managed by a nurse. The goal was to see if…

This study tested a program called Mates in Motion, which helps blood cancer patients and their caregiving partners support each other to be more physically active. 96 couples participated, with patients who had a stem cell transplant or CAR-T therapy. The program included walkin…

This pilot study tested a pain management program for cancer survivors living in rural areas or of Hispanic background. The program included acupuncture, cognitive behavior therapy, educational materials, and a pain clinic referral. The goal was to see if the program was feasible…

This study tested whether a brief electrical stimulation of the inner ear could temporarily reduce tinnitus (ringing in the ears) in 25 adults with severe, disruptive tinnitus. Researchers aimed to find the best spot for stimulation to guide development of a future implantable de…

This completed study tested whether wearing an InBody Band 3 fitness tracker for 6 weeks could help Black prostate cancer survivors become more active and improve their quality of life. Thirteen participants wore the tracker and had regular check-in discussions. The main goals we…

This study uses advanced heart imaging to understand how blood flows inside the heart in people with cardiac amyloidosis, a condition where abnormal proteins build up in heart tissue. Researchers will compare these images with those from healthy volunteers to find unique patterns…

This Mayo Clinic study tested whether a dietary supplement called Synaquell™ can affect brain function in 25 youth contact sport athletes. Participants took either the supplement or a placebo twice daily during their sport season. Researchers measured brain activity with EEG and …

This study looked at 24 people with lung or esophageal cancer who received radiation or chemo-radiation near the heart. Participants wore a small heart monitor to catch any heart changes that might otherwise go unnoticed. The goal was to see how often heart problems occur after s…

This study tested a program that provides early support to Minnesota workers who have been injured or become ill, to help them stay at work or return to work sooner. Over 3,400 adults who were employed but at risk of missing work for at least 4 weeks took part. The goal was to se…

This study looked at how much vitamin D sulfate is in breastmilk and whether it reaches infants. Researchers collected breastmilk samples from 101 lactating mothers before and after 28 days of vitamin D supplements, and also tested infant saliva and gut contents. The goal was to …

This study looked at whether a probiotic called Saccharomyces boulardii can help strengthen the gut's natural barrier in healthy adults. Researchers measured how well the gut keeps unwanted substances from leaking into the body. The study involved 56 healthy participants and comp…

This study tested 892 African and Asian immigrants for hepatitis B and C to understand how these infections raise the risk of liver cancer. Researchers also checked vaccination rates and tracked new cancer cases over time. No treatment was given; the goal was to gather informatio…

This study looked at 13 people undergoing a standard esophagus pressure test to see which breathing positions or maneuvers create the highest pressure at the junction between the esophagus and stomach. The goal is to learn how to better contract the diaphragm, which may help with…

This study looked at three different ways to close surgical wounds after spine surgery. Researchers measured blood flow around the wound to see if one method was better. The study involved 50 adults with spinal stenosis who had back surgery at Mayo Clinic.

This study looked at over 2,400 people with rheumatic diseases who take methotrexate. Researchers compared those who had standard lab monitoring to those who had fewer blood tests. The goal was to see if reduced monitoring is as safe in terms of preventing organ damage or death.

This completed Phase 4 trial at Mayo Clinic tested 21 healthy adults to find the highest skin-testing concentrations of midazolam, ketamine, and ondansetron that do not cause irritation. These drugs are commonly used before, during, and after surgery. The goal is to improve aller…

This study looked at skin samples from 20 breast cancer patients receiving radiation therapy to understand why some develop radiation dermatitis—itchy, red, swollen skin. Researchers took small skin biopsies from areas showing signs of irritation. The goal was to identify molecul…

This study tested a mobile-friendly app called HERCaRE, designed to help Black women who have finished breast cancer treatment. The app provides culturally tailored education and resources to support survivorship. Researchers measured how often participants used the app and wheth…

This completed study from Mayo Clinic interviewed 33 adults with brain or central nervous system (CNS) tumors, along with their caregivers, to learn about their biggest challenges and needs. The goal was to identify areas where doctors and healthcare teams can offer better suppor…

This study tested whether ultrasound can measure how tendons and nerves move inside the wrist in people with and without carpal tunnel syndrome. Researchers used sound waves to create images of the wrist in 257 participants. The goal was to better understand the condition, not to…

This study from Mayo Clinic looked at whether voice and speech change during manic episodes in people with bipolar I disorder. Researchers recorded interviews with 17 hospitalized participants and analyzed pitch, rhythm, grammar, and word choice. The goal was to find measurable d…

This study looked at how the asthma drug mepolizumab affects gene activity in adults with severe eosinophilic asthma. Researchers took blood samples from 20 participants before and after 12 weeks of treatment to see which genes changed. The goal was to understand how the drug wor…

This study looked at how well women of color understand their personal risk of developing breast cancer. Researchers surveyed 324 women aged 18 to 50 who had never had breast cancer. The goal was to see if their perceived risk matched actual risk, which can help improve education…

This Mayo Clinic study tested whether 3D surface images can replace standard CT scans for planning electron radiation therapy. Researchers used plastic models to compare dose accuracy between virtual CTs from 3D scans and real CTs. The goal is to reduce radiation exposure and spe…

This study looked at whether gradually lowering opioid doses over time affects pain, quality of life, and mood in people with chronic non-cancer pain. 18 adults on stable opioid therapy were followed to compare slow tapering versus staying on their current dose. The goal was to s…

This study looked at 21 pregnant women and their babies to understand how surgery before birth changes the immune system. The goal was to find out if immune system activation might cause early labor. Researchers collected blood samples and studied the placenta to track immune cha…

This study looked at 56 older adults (65+) with multiple myeloma to see if a comprehensive geriatric assessment—a series of questions and tests about physical and mental health—along with blood tests could predict who would have serious side effects from chemotherapy. The goal is…

This study looked at how certain immune cells (eosinophils) interact with fat tissue in people with obesity and insulin resistance. Four participants had fat biopsies and blood tests to measure immune cells and markers of inflammation. The goal was to better understand these inte…

This study followed 66 women for three months after a scheduled C-section to see how their health and pain changed over time. Participants filled out surveys about their overall health and pain levels. The goal was to understand the typical recovery pattern, not to test any new d…

This study tested a new type of gamma camera (the Veriton system) to see if it produces better images than a standard camera used in nuclear medicine. 41 adults who were already scheduled for a nuclear medicine exam took part. The goal was to compare image quality between the two…

This study collected information and samples from 105 breast cancer survivors and healthy volunteers to create a research database. The goal is to help doctors better diagnose cancer, predict long-term health, and develop future treatments. Participants provided blood, urine, and…

This Mayo Clinic study tested a wearable headset that uses mild electrical pulses to help people hear tones and understand speech. Researchers placed electrodes on the skin to deliver sound information directly to the brain. The study involved 68 healthy volunteers and measured h…

This study looked at immune cells in bone marrow and lymph nodes of kidney transplant donors and recipients. The goal was to create a detailed immune profile to better understand how the immune system works in transplantation. About 288 people took part, including both pre- and p…

This study tested how accurately a special treadmill delivers controlled pushes and pulls to a person's balance. Twelve healthy adults walked on the treadmill while sensors measured the belt's movements. The goal was to see if the treadmill's commands matched what actually happen…

This study from the Mayo Clinic looked at 219 people getting total knee replacements to see if a blood test measuring an enzyme called tryptase could predict knee stiffness (arthrofibrosis) after surgery. Researchers measured tryptase levels before and after surgery and checked i…

This study tested whether saliva samples can be used to remotely monitor cytomegalovirus (CMV) infection in people receiving treatment for ovarian cancer. Researchers compared saliva and blood samples from 49 participants, collected either at the clinic or at home. The goal was t…

This study from the Mayo Clinic looked at how resistance exercise (like weight lifting) improves insulin sensitivity and muscle health in people with insulin resistance and obesity. 58 participants aged 50-75 completed a 3-month exercise program. Researchers measured changes in m…

This study tested a special PET scan tracer (F-18 AV 1451) to see how much tau protein builds up in the brains of 81 people with primary progressive aphasia or frontotemporal dementia. Researchers compared these scans to those of healthy controls to find unique patterns for each …

This study looked at whether menopause makes the heart stiffer and reduces exercise ability in female endurance athletes. Researchers compared postmenopausal female athletes to premenopausal females and older male athletes using heart scans and exercise tests. The goal is to unde…

This study looked at how exercise and amino acid infusions change muscle protein production in people with obesity. Researchers measured how fast different muscle proteins were made in 48 volunteers. The goal was to understand why obesity alters muscle fiber types, which may lead…

This study tested whether a wearable device and smartphone app can monitor cancer patients' vital signs and symptoms as well as standard in-clinic checks. About 100 patients with various cancers participated, either after CAR-T cell therapy or during radiation treatment. The goal…

This study observed conversations between 37 lung cancer patients and their doctors to create a shared decision-making tool. The tool is designed to help patients who have had surgery decide whether to pursue additional treatment. Researchers aim to improve patient satisfaction b…

This study from Mayo Clinic looked at 97 liver transplant patients to see how often they had lasting muscle weakness after surgery when given sugammadex, a drug to reverse anesthesia. Researchers used a device called TetraGraph to measure muscle response. The goal was to estimate…

This study looked at whether detergents found in common products like toothpaste can make the lining of the esophagus leaky and cause allergic inflammation, which is a key feature of eosinophilic esophagitis. Researchers tested 12 healthy volunteers by measuring changes in the es…

This completed study from the Mayo Clinic looked at how different surgical practices adopt and use a non-drug pain management program called NOHARM. Researchers interviewed 372 patients and care team members to understand what helps or hinders the program's use. The goal was to f…

This study tested a device called SimPull to see if it makes moving a patient from one bed to another faster and safer than current methods. Researchers at Mayo Clinic studied 100 patients who needed to be moved for a heart procedure. They measured how long transfers took, how ma…

This study looked at whether a special PET scan (18F-DOPA) can help doctors better see brain tumors when planning radiation therapy. 91 adults with newly diagnosed gliomas were enrolled. The goal was to see if this scan improves treatment planning and helps predict how well patie…

This study from Mayo Clinic looked at 170 patients having elective surgery to find the best time to insert a breathing tube. Researchers compared intubating right after a muscle relaxant (standard care) versus waiting until a nerve monitor showed a specific level of relaxation. T…

This study looked at health records from over 386,000 adults with type 2 diabetes and moderate heart disease risk. Researchers compared four common second-line diabetes drugs to see which ones were linked to fewer heart attacks, strokes, and other complications. They also asked p…

This study looks at the genetic makeup of 1,500 people with Primary Biliary Cirrhosis (PBC), a rare liver disease, along with their close relatives. By comparing genes, researchers hope to find inherited factors that make someone more likely to develop PBC. The goal is to better …

This completed study looked at 101 adults who developed headaches within 7 to 56 days after a mild head injury. Researchers used brain scans, blood tests, and pain sensitivity tests to find clues about who might develop long-term headaches. The goal was to better understand the m…

This study tested whether a special MRI sequence called ZTE can show breast biopsy markers made of bone cement more clearly than standard metal markers. Twenty adults with breast cancer had MRI scans, and two radiologists rated how well the markers were seen. The goal is to impro…

This study looked at how the way blood samples are collected and processed affects the ability to detect tumor DNA in women with early-stage breast cancer. Researchers tested different collection tubes, processing speeds, and storage conditions to see which methods preserve tumor…

This study looked at the DNA of breast tumors from 140 patients to understand why some cancers are destroyed by standard chemotherapy and others are not. Researchers analyzed genetic changes in the tumors and compared them to normal DNA. The goal is to find new drug targets and i…

This pilot study tested whether a special PET scan using 18F-FDOPA can help doctors better plan surgery and radiation for people with newly diagnosed brain tumors (gliomas). Twenty-four adults took part at Mayo Clinic. The goal was to see if the scan provides useful information b…