Mayo Clinic

This study tested a drug called ixazomib, alone or with other medicines, in 165 people whose multiple myeloma had returned after treatment. The goal was to see if the drug could shrink or control the cancer. Participants received different combinations, and doctors measured how m…

This study tested whether using existing social networks could help Hispanic and Somali immigrants in Minnesota lose weight and improve heart health. About 475 participants joined, and researchers measured weight, waist size, and other health markers over 6 to 12 months. The goal…

This study tested a drug called daratumumab in 49 patients with multiple myeloma who were eligible for a stem cell transplant. The goal was to see if daratumumab could help eliminate remaining cancer cells in the bone marrow after transplant. While the treatment aims to control t…

This study tested whether a computer program (AI) can analyze heart sounds recorded with a special stethoscope to find common valve problems like aortic stenosis and mitral regurgitation. Researchers compared the AI's results to standard tests like echocardiograms (heart ultrasou…

This study tested whether an artificial intelligence (AI) tool could help doctors find cardiac amyloidosis, a rare and serious heart condition, earlier. Over 20,000 patients were involved, and doctors were randomly assigned to use the AI-enhanced ECG or standard care. The goal wa…

This study tested a new noninvasive method called SAVE that uses ultrasound to measure how breast masses move and stretch. The goal was to see if it can accurately tell benign lumps from cancerous ones without a biopsy. Researchers studied 266 women with breast lesions to compare…

This study tested whether an artificial intelligence (AI) program could find early signs of serious liver scarring (cirrhosis) by analyzing routine electrocardiogram (ECG) heart tests. Researchers compared doctors who received AI alerts about possible liver disease to doctors usi…

This study looked at two ways to prevent stroke in people with severe but symptom-free narrowing of the carotid artery. About 2,500 participants were randomly assigned to get either intensive medical management alone or medical management plus a procedure (surgery or stenting) to…

This study tested whether an education program helps low-income, uninsured adults aged 18-45 accept and complete a free HPV vaccine series. The goal is to prevent HPV-related cancers. About 100 participants took part, and researchers tracked how many started and finished the vacc…

This study tested a special water bottle nozzle designed to strengthen mouth and throat muscles through daily drinking. 43 adults with mild to moderate sleep apnea used the nozzle for 8 weeks. Researchers measured how well people stuck with the routine and whether it improved sle…

This early-stage study tested whether a single infusion of mesenchymal stem cells is safe and feasible for people with advanced COPD. Fifteen participants received the treatment and were monitored for any immediate side effects. The goal was not to cure the disease, but to see if…

This study tested a short-term electrical stimulation on the inner ear to see if it could safely and effectively reduce tinnitus (ringing in the ears) in 25 adults with severe, disruptive tinnitus. The goal was to find the best spot for stimulation to help design a future implant…

This study tested whether giving a very high dose of water pills (diuretics) is safe and works better than the usual dose for people hospitalized with worsening heart failure. Twenty adults with fluid overload received either ultrahigh or standard doses over 24 hours. Researchers…

This study tested whether using artificial intelligence (machine learning) to plan radiation treatment could reduce side effects like trouble swallowing for people with head and neck cancer. About 200 adults receiving curative radiation took part. Researchers compared standard pl…

This study tested whether a non-opioid painkiller called suzetrigine can control pain after outpatient facial plastic surgery and reduce the need for opioid pills. 100 adults took suzetrigine as part of their standard pain plan. Researchers tracked how many opioid pills they used…

This study looked at whether increasing physical activity through a 12-week virtual exercise program could improve physical function and quality of life in cancer survivors who are over 60 or live in rural areas. About 100 participants completed the program, which focused on endu…

This study tested whether ketoconazole, a drug usually used for fungal infections, can help reduce skin rashes caused by EGFR inhibitor cancer therapy. 58 participants with ongoing rash were randomly assigned to receive ketoconazole or a placebo. The main goal was to see if the d…

This study tested a cream made from cannabidiol (CBD) to see if it could reduce nerve pain, numbness, or tingling in the hands and feet caused by chemotherapy. Forty adults with cancer who had moderate to severe nerve symptoms took part. Half used the CBD cream and half used a pl…

This study compared two ways of giving methadone pain medication to patients having elective heart surgery. Researchers tested whether taking methadone as a pill before surgery works as well as getting it through an IV during anesthesia. The goal was to see which method provides …

This study tested a new type of gamma camera called Veriton, which is more sensitive and may produce clearer images than standard cameras. 41 adults scheduled for nuclear medicine exams had scans on both cameras so doctors could compare image quality. The goal was to see if the n…

This study looked at whether a blood enzyme called tryptase can predict knee stiffness and pain after total knee replacement. Researchers measured tryptase levels before and after surgery in 219 adults with knee osteoarthritis. The goal was to see if these levels could help ident…

This study tested a home-based system that uses remote monitoring and health coaching to help people with severe sleep apnea and obesity make healthy changes. 17 adults took part to see if the system was easy to use and helpful. The goal was to improve health and quality of life,…

This study tested whether 3D surface images can be used instead of standard CT scans to plan electron radiation therapy for adults with certain cancers. Researchers used plastic models (not real patients) to compare the accuracy of 3D scans and CT scans. If successful, this appro…

This completed study looked at 101 adults with new headaches after a mild head injury. Researchers tracked headache patterns, pain sensitivity, brain scans, and blood tests over time. The goal was to find what causes headaches to become long-lasting and how to prevent them.

This study looked at how well women of color understand their personal risk of getting breast cancer. Researchers surveyed 324 women aged 18 to 50 who had never had breast cancer. The goal was to learn about their perceptions of risk, not to test a treatment.

This study looked at how a drug called LCZ696 (used for heart failure) affects the kidneys and heart in 72 people with type 2 diabetes, some with early signs of heart stiffness and some without. Participants received a salt solution to test their body's response. The goal was to …

This study tested a mobile-friendly app called HERCaRE, designed to help Black breast cancer survivors manage life after treatment. The app provides culturally tailored educational materials and health resources. Researchers measured how often participants used the app and whethe…

This study looked at how well surgical teams and patients use a non-drug pain management program called NOHARM after surgery. Researchers interviewed 372 patients and care team members to understand what helps or hinders the use of these pain relief methods. The goal was to learn…