Could a Quit-Smoking pill soothe IBS pain?

NCT ID NCT06854406

First seen Jan 07, 2026 · Last updated May 25, 2026 · Updated 20 times

Summary

This small pilot study looked at whether varenicline, a drug used to help people stop smoking, can change how the rectum senses pressure in people with irritable bowel syndrome (IBS) who have chronic belly pain but not constipation. Eight adults took the drug and had balloon tests to measure rectal sensation and comfort. The goal was to see if the drug might ease pain by altering gut sensation, with safety also tracked.

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Contacts and locations

Locations

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

Conditions

Explore the condition pages connected to this study.