Mayo Clinic

This study tests whether the drug metyrapone can safely lower cortisol levels in people with mild autonomous cortisol secretion (MACS), a condition where the adrenal glands produce too much cortisol. Participants will receive either metyrapone or a placebo for a short period, and…

This phase II trial tests whether adding a targeted radiation drug (177Lu-PSMA-617) to standard hormone therapy, with or without additional hormone-blocking pills, can better control low-volume metastatic hormone-sensitive prostate cancer. The study enrolls men whose cancer has s…

This study compares two drugs, sodium bicarbonate and THAM, for treating metabolic acidosis in patients after heart surgery. About 250 adults who develop acidosis after using a heart-lung machine will be randomly assigned to receive one of the two drugs. The main goal is to see i…

This trial tests a drug called HRX215 in 80 adults with colorectal cancer that has spread to the liver. Before surgery to remove liver tumors, patients often get a procedure (PVE) that blocks blood flow to the tumor area to encourage the healthy part of the liver to grow. HRX215 …

This study tests a stent-graft that doctors modify before use to treat complex aortic aneurysms. It involves 20 high-risk patients who cannot have standard open surgery. The goal is to see if the device is safe and prevents aneurysm growth or rupture.

This study tests if lisinopril, a common blood pressure drug, can lower red blood cell levels in people with polycythemia (too many red blood cells). Researchers will measure changes in hemoglobin, hematocrit, and a hormone called erythropoietin. The trial enrolls 30 adults with …

This study tests whether adding daily lung ultrasound and vein pressure checks to standard care can help people with acute heart failure leave the hospital sooner and reduce the chance of coming back. About 500 adults admitted for heart failure will be randomly assigned to either…

This study follows 80 babies with severe congenital diaphragmatic hernia (CDH) who had a special surgery called FETO while still in the womb. Researchers want to see if these babies survive to leave the hospital more often and have fewer long-term health issues compared to babies…

This phase II trial tests whether adding the drug axatilimab to standard care can prevent graft-versus-host disease (GVHD) in 72 blood cancer patients receiving a stem cell transplant. GVHD occurs when donor cells attack the patient's body, causing serious symptoms. Axatilimab is…

This study tests the safety of using a patient's own stem cells (taken from fat) to prevent bile duct complications after a living donor liver transplant. About 20 adults with end-stage liver disease will receive these cells during surgery. The goal is to see if this approach red…

This study tests whether the drug Bimzelx (bimekizumab) can improve skin symptoms in adults with pityriasis rubra pilaris, a rare condition causing red, scaly patches. Researchers will enroll 12 participants and measure how many achieve at least 75% improvement in skin severity a…

This study tests whether a nurse navigator program can reduce hospital readmissions in 300 patients who are having hip or knee replacement and also have conditions like heart failure, COPD, or kidney problems. The program provides education and connects patients with their primar…

This phase II trial is testing whether giving the hormone therapy drug goserelin (Zoladex) as a shot in the upper buttock works as well as the standard belly injection for suppressing ovarian function in premenopausal women with hormone-positive breast cancer. About 98 patients w…

This study tests a new drug called ABBV-383 in 38 people with Waldenström macroglobulinemia that has come back or not responded to treatment. The drug is a monoclonal antibody designed to block cancer growth. The trial has two parts: first finding a safe dose, then checking how w…

This study tests whether taking oral tranexamic acid for three days after hip replacement surgery can reduce pain, swelling, and help patients walk sooner. About 101 adults with end-stage osteoarthritis will receive the drug or placebo. The goal is to see if this simple pill impr…

This study will test whether a combination of an AI-powered risk tool, a simple 'sponge on a string' test, and nurse navigation can improve screening for Barrett's esophagus and esophageal cancer. Over 1,000 adults at higher risk will be enrolled. The goal is to see if these less…

This study at Mayo Clinic will enroll 100 adults with atrial fibrillation who are taking the drug dofetilide. Researchers will compare a non-invasive magnetic heart scan (magnetocardiography, or MCG) with the standard ECG to see which better predicts safe drug dosing and heart co…

This study looks for protein markers in urine and blood that could help identify different types of kidney cancer without needing a biopsy. Researchers will analyze stored urine samples from 300 people and collect blood before and after kidney removal surgery. The goal is to deve…

This study will test a new iPhone app called FaceScan that uses LiDAR and voice recognition to measure visual acuity. Researchers at Mayo Clinic will compare the app's results to standard eye exams in 150 adult patients. The goal is to see if the app is accurate enough for home o…

This study tests whether a numbing injection around a nerve cluster in the neck, given just before heart bypass surgery, can prevent a common complication called atrial fibrillation (irregular heartbeat) in the first week after surgery. About 450 adults scheduled for bypass will …

This pilot study aims to see if offering self-collection kits for cervical cancer screening and HPV vaccination in emergency departments can reach women who have limited healthcare access. Researchers will enroll 100 women aged 18-65 and track how many participate and complete th…

This study tests whether taking low-dose aspirin can lower inflammation in the womb lining and help prevent endometrial cancer. It involves 25 postmenopausal women who have non-atrophic endometrial changes and pain. Participants will be randomly assigned to take aspirin or not, a…

This pilot study tests whether a device called Flyte can help improve urinary incontinence in women who had radiation therapy for endometrial or cervical cancer. The Flyte device is used at home and delivers gentle vibrations while the user does Kegel exercises. The study will ch…

This study tests a virtual group program designed to help people with advanced cancer build resilience and manage stress, anxiety, and fatigue. Participants attend seven weekly online sessions that teach techniques like mindfulness, gratitude, and reframing difficult experiences.…

This study tests whether a seven-session, telehealth-based therapy called Meaning-Centered Psychotherapy is practical and helpful for stem cell transplant survivors and their main caregivers. The program aims to help dyads stay connected to meaning, cope with difficult experience…

This study compares a physical activity program to a health education program for improving memory and attention in Hispanic women aged 50 and older who have been treated for early-stage breast cancer. Researchers want to see if aerobic exercise can help with cognitive problems l…

This study tests a virtual behavioral program for people with chronic migraine. Researchers want to find the best combination of techniques and see if letting patients choose their treatment helps. The goal is to reduce migraine frequency and intensity.

This study tests whether weekly virtual reality sessions can help manage menopause symptoms like hot flashes and night sweats. Women aged 45 to 60 who have at least 28 hot flashes per week will use a VR headset at home for 8 weeks. Researchers will track changes in hot flash freq…

This study compares two common shoulder replacement surgeries—anatomic and reverse—for people with shoulder arthritis and an intact rotator cuff. Researchers want to see which surgery leads to better pain relief and function one year after the procedure. About 108 participants wi…

This study looks at how a cannabis-based drug (Dronabinol) affects blood pressure and heart function. Researchers will measure blood pressure, heart rate, and nerve activity in 50 healthy adults aged 21-40 who use cannabis occasionally. The goal is to see if cannabis can help man…

This study tests whether THC (with or without CBD) can improve sleep in people with solid organ cancer who have insomnia. About 69 participants will receive either THC, a THC/CBD mix, or a placebo as a liquid under the tongue. The goal is to see if these cannabis-based compounds …

This study tests whether taking dronabinol (a cannabis-derived medication) before bed can help people with obstructive sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressure. Th…

This study tests a smartphone app called Senyo Health for people with bipolar disorder who also struggle with alcohol or drug use. The app offers therapy, rewards for healthy behaviors, and weekly check-ins with a care manager. The goal is to see if the app is easy to use and hel…

This study tests if health and wellness coaching helps people with papillary or follicular thyroid cancer follow their treatment plans and live healthier lives. Twenty adults who have had their thyroid removed and take daily thyroid medication will work with a coach to set goals …

This study tests a virtual reality assistant called ViRA designed to provide emotional support and help with daily needs like food and transportation for Black men recently diagnosed with prostate cancer. About 200 participants will use the ViRA app and researchers will measure h…

The RADiaNT study at Mayo Clinic will test if guided meditation using the Muse headband can improve sleep, mood, and thinking in 40 adults with normal cognition or mild impairment. Participants meditate 5 minutes a day, five times a week for two 6-week periods. The study tracks s…

This pilot study will test whether bright light therapy can help reduce behavioral and psychological symptoms like agitation in people with dementia. Researchers plan to enroll 70 adults on inpatient units at Mayo Clinic. Participants will receive 60-minute sessions of light ther…

This study at Mayo Clinic will test if dry needling with electrical stimulation can improve sleep and reduce symptoms in people with restless legs syndrome. Twenty adults aged 18-75 with a clinical diagnosis will receive two weekly sessions targeting leg muscles. Researchers will…

This study will give 200 plastic surgery patients access to an artificial intelligence virtual assistant called AIVA. The assistant answers questions about their upcoming surgery. Researchers want to see if this reduces phone calls to clinic staff and improves patient and provide…

This study tests whether adding a neutral shoe insert to standard physical therapy helps people with long-term hip pain (greater trochanteric pain syndrome). About 36 adults with unilateral hip pain for over three months will be assigned to physical therapy plus a shoe insert on …

This study tests whether adding special air quality sensors and software to hospital ventilation systems can lower the number of respiratory infections among healthcare workers. About 850 Mayo Clinic staff will report symptoms and provide self-swabs when sick. The goal is to see …

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study compares two approaches to notify relatives of people diagnosed with familial hypercholesterolemia (FH), a genetic condition causing very high cholesterol. One method lets patients share information themselves; the other has the study team contact relatives directly. R…

This study will collect blood samples from 115 adults with cardiac sarcoidosis to look for tiny particles called exosomes that might show whether the disease is active or quiet. The goal is to develop a simple blood test that could help doctors monitor the condition without needi…

This early study at Mayo Clinic tests a new implantable device called the Brain Interchange System in up to 8 people with drug-resistant epilepsy. The device records high-speed brain signals and can deliver targeted electrical stimulation to prevent seizures. Unlike current syste…

This study looks at how fat tissue in the upper body reacts after a meal, comparing people with obesity to those at a healthy weight. Researchers will measure blood flow and tiny particles called exosomes released by fat cells. The goal is to better understand how fat tissue work…

This study uses a special PET scan to look for signs of inflammation in the brains of people with Post-COVID syndrome. Researchers want to learn more about why some people have long-lasting symptoms after a COVID-19 infection. Ten Mayo Clinic patients who had COVID-19 and are exp…

This study looks at how menopausal hormone therapy (MHT) affects the heart's ability to pump blood. Researchers will compare heart function in postmenopausal women who use MHT and those who don't. The goal is to understand the role of the nervous system in these changes. About 50…

This study asks Black women aged 45 and older how they feel about using a vaginal fluid sample to test for DNA markers of endometrial cancer. The goal is to understand if women would accept this as a screening method. No treatment is given—just a 30-minute virtual interview to ga…

This study will compare two methods for locating the ulnar nerve in the wrist: using ultrasound imaging versus measuring physical landmarks. Researchers will enroll 40 healthy adults to see which technique is more reliable for placing stimulating electrodes. The goal is to improv…

This study looks at how long the drug calaspargase pegol stays at effective levels in the blood of children and young adults with acute lymphoblastic leukemia or lymphoma. Researchers will measure drug activity and check for links to side effects. The goal is to better understand…

This Mayo Clinic study will test whether a special ultrasound technique, called shear wave elastography, can measure how stiff brain tumors are compared to healthy brain tissue during surgery. Researchers will enroll 30 adults with newly diagnosed or recurrent brain tumors. The g…

This early study tests whether a small device can safely collect fluid from the brain during planned surgery for glioma or epilepsy. Six participants will have the device placed temporarily during their operation. The goal is to see if the device works and is safe, not to treat t…

This study will check how well pulse oximeters measure oxygen levels when blood flow to the hand is increased or decreased. Twenty healthy adults will breathe lower-oxygen air while researchers compare oximeter readings to blood samples. The goal is to see if changes in hand bloo…

This study aims to understand how insulin deprivation and high blood sugar affect protein synthesis in muscles and blood of people with type 1 diabetes. Researchers will use muscle biopsies and special amino acid labels to track protein production. The study involves 70 participa…

This study looks at how a common genetic change (the T allele at rs7903146) affects the pancreas's own production of GLP-1, a hormone that helps control blood sugar. Researchers will give 80 healthy adults a drug that blocks GLP-1 receptors to see how their insulin and glucagon l…

This study observes 100 patients having elective brain surgery to clip an aneurysm. Some take daily low-dose aspirin, others do not. Researchers track bleeding during surgery and on CT scans afterward to understand the risks. The goal is to help doctors decide whether to stop or …

This study aims to understand how resistance exercise (like weight lifting) helps muscles use insulin better to control blood sugar. Researchers at Mayo Clinic will study 16 sedentary adults who are weight-stable. Participants will undergo exercise training, and scientists will m…