Mayo Clinic

This study is testing whether a mild electrical stimulation to a nerve in the neck, called vagus nerve stimulation, can help people quit smoking when used alongside nicotine patches. It will involve 150 adult smokers who want to quit. The main goal is to see if this combination l…

This study is testing if giving a standard hormone-blocking injection for breast cancer in the upper buttock area works as well as giving it in the abdomen. It involves about 100 premenopausal women with early-stage, hormone-sensitive breast cancer who are already receiving this …

This study aims to see if certain blood pressure medications can protect the heart's blood vessels from damage caused by common chemotherapy drugs for stomach and colon cancers. Researchers will monitor 60 patients with gastrointestinal cancer who are receiving drugs like 5-FU or…

This study aims to measure how long a specific leukemia drug (calaspargase pegol) stays at an effective level in children's blood after it is given. It will involve about 20 children and young adults with acute lymphoblastic leukemia or lymphoma. The researchers also want to see …

This study aims to find out if two commonly used medications for treating acid imbalance (metabolic acidosis) after heart surgery work equally well. Researchers will compare sodium bicarbonate and THAM in 250 patients who develop this condition during their recovery. The trial wi…

This study is testing a combination of two drugs, retifanlimab and DFMO, for people with aggressive brain tumors that have started growing again. The first goal is to find a safe and tolerable dose of DFMO to give with retifanlimab. Researchers will then see if this combination h…

This small study is testing if an existing medication, Bimzelx, can help adults with a rare and severe skin condition called Pityriasis Rubra Pilaris (PRP). The goal is to see if the drug can significantly clear skin lesions and improve patients' quality of life over 24-28 weeks.…

This study aims to find out if a newer injectable drug (dupilumab) works better than a swallowed steroid liquid (budesonide) at widening the esophagus and reducing scar tissue in adults with eosinophilic esophagitis (EoE). Researchers will measure changes in the esophagus after 1…

This small pilot study is testing if a common blood pressure medication called spironolactone can reduce stiffness in the main artery leaving the heart (the aorta) in people with a thoracic aortic aneurysm. The goal is to see if the drug helps control the condition by making the …

This study is testing a new drug called ABBV-383 for people with Waldenström macroglobulinemia, a rare blood cancer, that has come back or stopped responding to other treatments. The first part of the trial will find the safest dose, and the second part will see how well the drug…

This study is testing whether adding a special type of PET/CT scan to standard brain imaging helps doctors make better treatment decisions for patients with brain tumors. Researchers want to see if this new scan changes the patient's care plan in more than half of cases. The stud…

This study aims to see if a new type of heart scan called magnetocardiography (MCG) is better than the standard ECG at predicting which patients with a specific heart rhythm condition (Long QT syndrome) can safely take the medication dofetilide. Researchers will enroll 100 adults…

This study aims to improve early detection of Barrett's esophagus, a condition that can lead to esophageal cancer. Researchers are testing a combination of an AI-powered risk assessment tool and a less invasive 'sponge on a string' screening test, supported by nurse guidance. The…

This study aims to test how accurate a new digital device is at measuring how well people see (visual acuity). Researchers will compare the device's results to standard eye exams performed in the clinic. The study will also collect voice recordings of people reading letters aloud…

This study is testing a new type of PET scan to see if it can better find the tiny pituitary tumors that cause Cushing's disease. It will involve 50 adults with Cushing's disease who are scheduled for surgery. The goal is to see if this scan is more accurate than current MRI scan…

This study aims to test how well new artificial intelligence (AI) tools can screen for heart disease. It will enroll about 19,300 participants, including teenagers, adults, and pregnant women. The AI will analyze simple heart tests (ECG and ultrasound) to see if it can accurately…

This study aims to develop a non-invasive test using urine and blood samples to better identify and classify kidney cancer types. Researchers will analyze tiny particles in urine from 300 patients to find protein markers that distinguish between cancer subtypes. They will also ch…

This study is testing new artificial intelligence (AI) software designed to help doctors analyze heart ultrasound scans. The goal is to see if the AI can help doctors identify serious heart conditions—like genetic heart disease, blocked arteries, and cardiac amyloidosis—more cons…

This study is testing whether low-dose aspirin can reduce inflammation and prevent endometrial (uterine) cancer in postmenopausal women who have certain tissue changes. Researchers will enroll 25 women who are already scheduled for a biopsy and randomly assign them to take aspiri…

This study is testing whether adding an experimental drug called axatilimab to standard care can better prevent graft-versus-host disease (GVHD) in adults with blood cancers receiving a stem cell transplant from a donor. GVHD is a serious complication where the donor's immune cel…

This study is testing if a special nurse-led education and support program can help high-risk patients avoid being readmitted to the hospital after hip or knee replacement surgery. It will involve 300 patients who have conditions like heart failure, COPD, or are on dialysis. The …

This study tests a virtual reality (VR) assistant designed to support Black men recently diagnosed with prostate cancer. The VR tool uses artificial intelligence to provide personalized emotional support, education, and help finding resources like food or transportation. Research…

This study aims to see how patients feel about receiving a massage from a robotic device called EMMA compared to a human massage therapist. Researchers want to understand if people find the robot massage helpful for lower back pain. The study will include 40 adults with lower bac…

This study is testing whether daily light therapy can help reduce agitation and behavioral symptoms in people with dementia. Researchers will enroll 70 hospitalized patients with dementia who experience these symptoms. Participants will receive light therapy for five days to see …

This study aims to see if a guided physical activity program is better than general health education at improving memory, attention, and thinking skills in Hispanic women aged 50+ who have recently finished treatment for early-stage breast cancer. Researchers will enroll 10 parti…

This Mayo Clinic study is testing whether dry needling with electrical stimulation can help people with restless legs syndrome. Researchers will measure changes in sleep quality, symptom severity, and daily function in 20 participants. The treatment involves inserting thin needle…

This study is testing whether adding a neutral shoe insert to standard physical therapy helps people with chronic pain on the outside of their hip. Researchers will compare three groups: physical therapy with the real insert, with a fake insert, or therapy alone. They want to see…

This study aims to see if an AI virtual assistant on a phone app can reduce the burden of phone calls for plastic surgery patients and improve their experience. Researchers will compare 200 patients who use the AI assistant at home to those who call a standard care center with th…

This Mayo Clinic study is testing whether using virtual reality (VR) can help reduce pain for people hospitalized with broken bones. Researchers want to see if VR can lower the need for strong painkillers like opioids and improve the hospital experience. They will enroll 100 pati…

This study is testing a new, FDA-approved pain medication called suzetrigine for patients recovering from elective facial plastic surgery. The goal is to see if this non-opioid pill can effectively manage pain and reduce the need for traditional opioid painkillers after surgery. …

This study is testing whether taking an oral medication called tranexamic acid for an extended period after a hip or knee replacement helps patients recover faster. Researchers will measure pain levels, how quickly patients can walk on their own, swelling, and complication rates.…

This study aims to see if patients feel comfortable and satisfied when talking to an AI-powered avatar instead of a human doctor before an appointment. It will involve 150 patients scheduled for a visit about a specific heart condition called Spontaneous Coronary Artery Dissectio…

This study aims to understand if continuing daily low-dose aspirin before elective brain aneurysm surgery increases bleeding risks. Researchers will observe 100 patients—some on aspirin and some not—across multiple hospitals, tracking bleeding during surgery and on scans afterwar…

This study aims to better understand how changes in lung blood vessels affect people with heart valve problems who are scheduled for valve repair or replacement. Researchers will observe 600 patients to identify patterns that predict which patients are more likely to see improvem…

This study aims to understand how a lack of insulin affects the body's production of proteins in the blood, which may be linked to long-term complications of Type 1 Diabetes. Researchers will compare people with Type 1 Diabetes and people without diabetes, using advanced lab tech…

This study is testing a special ultrasound tool to measure how stiff brain tissue and tumors are during surgery. Researchers want to see if this tool works well and if stiffness differs between healthy brain and tumor areas. The information could help surgeons better identify tum…

This study aims to understand how a specific gene variant, known to increase the risk of type 2 diabetes, affects the function of insulin-producing cells in the pancreas. Researchers will compare 80 people with different versions of this gene by measuring their blood sugar and ho…

This study is testing a new type of medical imaging machine called the StarGuide SPECT/CT system. Researchers want to see if it can take clearer pictures and work faster than the scanners currently used in hospitals. The study will involve 100 people who are already scheduled for…

This study aims to discover the biological reasons why resistance exercise (like weight training) improves how muscles respond to insulin and use blood sugar. Researchers will enroll 16 sedentary adults to measure changes in muscle proteins after exercise training. The goal is to…

This study aims to see if offering cervical cancer screening and HPV vaccine information in emergency rooms can help reach more women. Researchers will ask 100 women aged 18-65 to do a simple HPV self-test and provide vaccine info. The goal is to learn if this approach works for …

This study is testing a new external brain device to see if it can detect specific brain signals that may predict epileptic seizures. Researchers will use the device to record brain activity and deliver targeted electrical stimulation in 8 patients with drug-resistant epilepsy wh…

This study aims to understand how blood flow and the release of tiny particles from upper body fat tissue differ between people with normal weight and people with obesity after eating a meal. Researchers will measure these changes by taking specific blood samples from the fat tis…

This Mayo Clinic study aims to understand how menopausal hormone therapy affects how the nervous system controls heart pumping. Researchers will compare heart function in 50 postmenopausal women who use hormone therapy versus those who do not. The study will measure how much bloo…

This study aims to see how accurately common pulse oximeter devices measure blood oxygen levels, especially in people with darker skin tones. Researchers will compare the readings from finger-clip devices to direct measurements from blood samples taken at the same time. The goal …

This study aims to understand how a cannabis-based medication called Dronabinol affects blood pressure and heart health. Researchers at Mayo Clinic will enroll 50 healthy adults aged 21-40 who occasionally use cannabis. The study will measure participants' blood pressure, heart r…

This study aims to understand what normal pancreatic fluid looks like. Researchers will collect fluid from healthy volunteers who are already scheduled for a routine stomach scope. They will give participants a drug called CHIROSTIM to stimulate the pancreas before collecting the…

This study aims to see if drinking whole-fat milk affects heart and metabolic health in adults with metabolic syndrome. Researchers will measure changes in cholesterol, blood sugar, and blood vessel function in 40 participants. The goal is to gather knowledge about how dairy migh…