Mayo Clinic

This study tests two drugs—retifanlimab (an immunotherapy that helps the immune system attack cancer) and DFMO (which slows tumor growth)—in people with progressive high-grade gliomas, aggressive brain tumors. The goal is to find the safest and most effective dose and see if the …

This study tests whether spironolactone, a medication typically used for heart failure, can reduce stiffness in the main artery of patients with a thoracic aortic aneurysm. Fifty adults with an enlarged aorta will receive either spironolactone or a placebo for a short period. The…

This early study tests whether a patient's own fat-derived stem cells can safely prevent bile duct complications after a living donor liver transplant. About 20 adults with end-stage liver disease will receive these cells during surgery. The main goal is to check for side effects…

This early-phase study at Mayo Clinic will test whether a special PET scan (FET PET/CT) can better locate ACTH-secreting pituitary adenomas in 50 adults with Cushing disease who are scheduled for surgery. The goal is to see how accurate the scan is compared to standard MRI and fi…

This study tests if health and wellness coaching helps people with papillary or follicular thyroid cancer follow their treatment plans and live healthier lives. Twenty adults who have had their thyroid removed and take daily thyroid medication will receive six coaching sessions. …

This study tests if guided meditation using the Muse headband and app can help improve sleep, mood, and thinking. About 40 adults with normal or mild memory issues will use the device at home and report changes. The goal is to see if this simple, non-drug approach can ease stress…

This study uses a special ultrasound technique during brain surgery to measure how stiff the tumor and healthy brain tissue are. Researchers want to see if this method can help tell the difference between tumor and normal tissue. The goal is to use this information in the future …

This study will interview 25 Black women aged 45 or older to learn if they would accept using a vaginal fluid DNA test for early detection of endometrial cancer. The goal is to understand women's views on this potential screening method. No treatment or diagnosis is given; it is …

This study tests whether an artificial intelligence virtual assistant (AIVA) can help plastic surgery patients by reducing the number and length of phone calls to the clinic. Researchers will track phone calls and satisfaction among 200 adult patients at Mayo Clinic Florida. The …