Heart surgery acidosis: which drug works best?
NCT ID NCT07424625
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two drugs, sodium bicarbonate and THAM, for treating metabolic acidosis in patients after heart surgery. About 250 adults who develop acidosis after using a heart-lung machine will be randomly assigned to receive one of the two drugs. The main goal is to see if the drugs are equally effective at raising blood pH levels.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sodium bicarbonate and THAM (tris-hydroxymethyl aminomethane)
What this could lead to
If the drugs are found to be equivalent, doctors may have a safe alternative to sodium bicarbonate for treating acidosis after heart surgery.
What could go wrong
This is a small, early-phase trial (250 patients) comparing two existing drugs, so it is unlikely to lead to a major breakthrough. The study only looks at short-term blood chemistry changes, not long-term outcomes.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Mayo Clinic
Rochester, Minnesota, 55901, United States
Contact
Contact Phone: •••-•••-••••