Mayo Clinic

This early-stage study aimed to find a safe dose and test the initial effects of a new oral drug called NXP800 for patients with advanced bile duct cancer (cholangiocarcinoma) that had spread or stopped responding to standard treatments. The drug works by blocking a specific path…

This study tested whether a specially engineered measles virus could be a better treatment than standard chemotherapy for women with advanced ovarian, fallopian, or peritoneal cancer that had stopped responding to platinum-based drugs. Participants were randomly assigned to recei…

This early-phase study tested the safety and best dose of an immunotherapy drug called STI-3031. The drug was delivered directly into the lymph vessels or nodes of a single limb using a special device, aiming to treat melanoma that had spread locally. The goal was to see if this …

This study tested whether adding an immunotherapy drug called bintrafusp alfa to standard chemotherapy (docetaxel) could better control advanced non-small cell lung cancer in patients whose cancer had worsened despite previous treatment with immunotherapy and chemo. The trial aim…

This early-phase study tested a genetically modified virus designed to kill melanoma cancer cells. The virus was injected directly into tumors and given intravenously to patients with advanced melanoma that had stopped responding to standard treatments. The main goals were to fin…

This study tested a combination of two oral drugs, ibrutinib and ixazomib, for patients with Waldenström macroglobulinemia, a rare type of blood cancer. The goal was to see if taking these two drugs together was safe and effective for patients whose cancer was newly diagnosed, ha…

This study tested a personalized treatment plan for patients with multiple early-stage lung tumors. Doctors used genetic sequencing of the tumors to guide a combination of targeted drug therapy and surgery or radiation. The goal was to see if this aggressive, tailored approach co…

This study tested whether a drug called P1101 could help control myelofibrosis, a rare cancer that scars the bone marrow. It involved 11 patients with early-stage disease who received injections every two weeks. The main goal was to see if the treatment could shrink enlarged sple…

This study tested if adding a precise, high-dose form of radiation therapy to standard chemotherapy could better control pancreatic cancer that had spread to only a few other places in the body. It aimed to see if this combination could slow the cancer's progression and help pati…

This study tested if a drug called abemaciclib could help control a hard-to-treat type of breast cancer that did not fully respond to standard chemotherapy. It involved 26 women whose cancer could still be surgically removed. The goal was to see if taking the drug for a short per…

This study tested a focused form of proton radiation therapy for adults with liver cancer. The main goal was to see if this treatment was safe for the liver and to measure how well it controlled the tumors. The trial was small and ended early, so its results are limited.

This study tested a new way to care for patients who go home from the hospital with a chest tube still in place after lung surgery. Researchers wanted to see if giving patients antibiotics and checking in with them by phone twice a week could prevent serious chest infections, com…

This study tested whether combining two drugs, daratumumab and ibrutinib, works better than ibrutinib alone for patients whose chronic lymphocytic leukemia (CLL) has come back or stopped responding to previous treatments. Daratumumab helps the immune system target cancer cells, w…

This small, early-stage study tested if a special, targeted radiation technique called 'grid therapy' could help the immunotherapy drug durvalumab work again for patients with non-small cell lung cancer. The patients had already tried durvalumab, but their cancer started growing …

This study tested whether adding a special microscopic camera inside a biopsy needle could help doctors diagnose lung cancer more accurately during a standard lung exam. Patients with suspicious lung nodules were randomly assigned to receive either the standard biopsy or the biop…

This study aimed to see if a new test could detect prostate cancer by looking for specific DNA markers in a person's urine. Researchers enrolled 24 men, some with confirmed prostate cancer and some scheduled for a biopsy, to collect urine samples. The goal was to check how accura…

This study tested a new type of brain scan to help doctors tell the difference between cancer that has returned and damage caused by previous radiation treatment. It involved 19 patients with brain cancer that had spread. The goal was to see if the special imaging tracer could ma…

This study tested a device called Brain4Care that measures pressure inside the skull without surgery. It aimed to see if the device could safely and effectively detect dangerous pressure changes early in adults with brain lesions who were being monitored in intensive care. The go…

This study tested whether a special smartwatch could accurately measure blood sugar and blood pressure without needles or traditional cuffs. It involved 87 hospitalized patients with diabetes who were already having their vital signs monitored. The goal was to compare the watch's…

This study tested a device that analyzes a person's breath to see if they have properly fasted before a scheduled medical procedure. Researchers wanted to see if this quick, non-invasive check could help prevent procedure cancellations and improve patient safety. The study involv…

This study tested two forms of a breast cancer prevention drug, tamoxifen, in women at high risk for the disease. It compared a standard oral pill to a new topical gel applied to the breast, aiming to see if the gel could work while causing fewer side effects. Researchers measure…

This study tested whether a special surgical technique performed during lymph node removal could prevent lymphedema, a painful and chronic swelling of the arm. It involved 264 patients with breast cancer or melanoma who were having lymph nodes removed. Researchers compared standa…

This study tested whether fenofibrate, a cholesterol medication, could prevent bile duct damage in people who received liver transplants from deceased donors. The trial involved just 6 participants and was terminated early. Researchers wanted to see if taking the drug daily for 1…

This study tested whether a handheld device called SinuSonic could reduce facial pain and pressure from sinus headaches. The device combines gentle vibration with breathing pressure. Researchers compared it to a fake device in a small group of adults with chronic facial pain.

This study tested if a wearable device called Nerivio could reduce the pain people feel when getting their regular Botox injections for chronic migraine. The device uses gentle electrical pulses on the arm to try to interfere with pain signals. The trial was stopped early and did…

This study tested whether the antibiotic rifaximin could reduce bloating symptoms in people with diabetic gastroparesis, a condition where the stomach empties too slowly. The small trial involved just 5 participants and was terminated early. Researchers measured symptom changes u…

This study aimed to find the best dose of a strong pain medicine given directly into the spine for teenagers having major back surgery for scoliosis. Researchers tested different doses in a small group of patients to see which one provided the most pain relief with the fewest sid…

This study tested whether the antibiotic rifaximin could reduce severe stomach pain, diarrhea, and other gut problems caused by a standard breast cancer drug combination. It involved 20 women with early-stage HER2-positive breast cancer who were experiencing these side effects. T…

This study aimed to see if a special nerve block given before major pancreas surgery (pancreaticoduodenectomy) could better control pain after the operation compared to standard care. Researchers planned to measure patients' pain levels, how long they stayed in the hospital, and …

This study aimed to see if remote monitoring could help predict when patients might have problems recovering from major surgery. It involved 56 adults who tracked their daily exercise and symptoms using wearable devices and logs. The goal was to develop computer algorithms that c…

This study created a registry to collect and store tissue and blood samples from patients undergoing surgery or biopsy for liver or bile duct tumors. The samples are used for future research to better understand these cancers and develop new treatments. The study enrolled 1,000 p…

This study aimed to find genetic markers that could predict how quickly squamous cell lung cancer might worsen. Researchers collected small tissue and blood samples from patients who had or were having lung procedures. The goal was to analyze the DNA from these samples to identif…

This study aimed to understand if a patient's heart function influences how quickly they recover from a muscle-relaxing drug given during surgery. Researchers measured the time it took for the reversal drug to work and checked if it was linked to how much blood the heart was pump…

This study aims to find early markers that can predict which sarcoma patients are most at risk for heart damage from chemotherapy. Researchers will use advanced heart imaging techniques to monitor 400 patients receiving standard doxorubicin treatment at Mayo Clinic. The goal is t…

This study aimed to understand how common a specific blood cell condition (monoclonal B-cell lymphocytosis) is in people with chronic hepatitis C. Researchers observed 29 participants to see if treating the hepatitis C virus affected this blood cell condition. The study was termi…