Mayo Clinic

This study looked at whether adding a precise type of radiation (stereotactic body radiation therapy) to standard chemotherapy could better control pancreatic cancer that has spread to only a few spots in the body. The trial planned to enroll patients with limited metastases, but…

This study looks at whether the beta-blocker carvedilol can prevent or treat heart problems in breast cancer patients receiving HER2-targeted therapy. About 184 adults with HER2-positive breast cancer will be randomly assigned to take carvedilol either preventatively or only afte…

This phase II trial tested whether the drug ibrutinib could prevent chronic graft-versus-host disease (GVHD) in adults who had received a donor stem cell transplant. Only 2 people enrolled before the study was terminated early. Because of the very small number of participants, no…

This study tested a combination of two drugs, ibrutinib and ixazomib, in 21 people with Waldenström macroglobulinemia, a rare blood cancer. The goal was to see if the combo could shrink or control the cancer. The trial was stopped early, so results are limited, but the approach a…

This study compared two drugs, obinutuzumab and rituximab, for treating a rare autoimmune disease that inflames blood vessels (ANCA-associated vasculitis). The goal was to see if obinutuzumab could help more patients achieve remission and clear disease markers. However, the trial…

This study tested a surgical method to prevent lymphedema (arm swelling) in people having lymph nodes removed for breast cancer or melanoma. The technique, called axillary reverse mapping with lympho-venous bypass, aims to preserve arm drainage while removing cancer-affected node…

This early study tested whether combining the immunotherapy drug durvalumab with a special type of radiation called grid therapy could help people with non-small cell lung cancer whose cancer had stopped responding to durvalumab alone. Only 4 patients were enrolled before the stu…

This early-stage trial tested a modified virus (VSV-IFNbetaTYRP1) in 12 patients with advanced melanoma that had spread or could not be removed by surgery. The virus was designed to infect and kill melanoma cells while also boosting the immune system's attack. The main goals were…

This phase II trial tested a combination of two drugs—daratumumab and ibrutinib—in people with chronic lymphocytic leukemia (CLL) that had come back or stopped responding to treatment. The goal was to see if the combo could shrink or eliminate cancer better than ibrutinib alone. …

This phase II trial tested a precise type of radiation called proton beam therapy in 9 people with liver cancer. The goal was to see if it could control the cancer while limiting damage to the liver. The study was stopped early, so the findings are limited, but early data suggest…

This early-stage trial tested a new drug called NXP800 in 7 people with advanced bile duct cancer that had spread or stopped responding to treatment. The goal was to find a safe dose and see if the drug could shrink tumors by blocking a protein linked to cancer growth. However, t…

This phase 2 trial tested a genetically modified measles virus (MV-NIS) against standard chemotherapy in 17 women with ovarian, fallopian, or peritoneal cancer that no longer responded to platinum drugs. The virus was designed to infect and kill cancer cells while leaving healthy…

This early-phase trial tested whether giving the immunotherapy drug STI-3031 directly into the lymph nodes or vessels (using a special device) is safe for people with in-transit melanoma, a type of skin cancer that spreads through lymph channels. Only 3 people took part before th…

This study tested whether adding bintrafusp alfa (an immunotherapy) to standard chemotherapy (docetaxel) helps people with advanced non-small cell lung cancer who have already tried other treatments. Only 10 people took part before the study was stopped early. The goal was to see…

This study looked at whether the drug abemaciclib could help people with triple negative breast cancer that didn't respond to standard chemotherapy. The goal was to see if the drug could change the tumor's immune environment to make it more attackable by the body's defenses. The …

This phase 2 trial tested a drug called P1101 (a type of interferon) in 11 people with early myelofibrosis, a rare bone marrow disorder. The goal was to see if the drug could shrink the spleen, improve symptoms, or boost blood counts. The study was terminated early, so the full r…

This study tested whether the drug fenofibrate could prevent a type of bile duct damage called ischemic cholangiopathy in people who received a liver from a donor after circulatory death. Only 6 participants were enrolled before the trial was terminated early. The main goal was t…

This study looked at whether giving oral antibiotics and having twice-weekly phone check-ins could reduce chest infections in people sent home with a chest tube and valve for a prolonged air leak. It compared this approach to standard care, where patients simply call their care t…

This pilot study tested whether a special PET scan (FDG-PET/CT) can detect hidden heart inflammation in cancer patients receiving immune checkpoint inhibitors (ICIs). The goal was to catch this inflammation early, before it becomes severe. Only 2 participants were enrolled, and t…

This study looked at whether tiny bits of RNA in the blood can serve as markers for liver disease and liver cancer. Researchers collected blood samples from nearly 1,900 people with liver cancer, cirrhosis, or chronic liver disease. The goal was to see if these RNA markers could …

This Mayo Clinic study tested a special smartwatch that uses light sensors to measure blood glucose, blood pressure, and heart signals. The goal was to see if the watch could give accurate readings compared to standard methods like finger-stick tests and blood pressure cuffs. The…

This study tested whether adding a special laser imaging technique (nCLE) and a dye (fluorescein) to a standard needle biopsy could help doctors diagnose lung cancer more accurately. The plan was to compare the combined approach to the standard biopsy alone in people with suspici…

This study tested whether a PET scan using a radioactive tracer called 18F-Fluciclovine can tell the difference between a returning brain tumor and damage from past radiation therapy. Nineteen people with brain metastases who had suspicious MRI findings took part. The goal was to…

This study aimed to see if a tamoxifen skin gel could work as well as the pill to lower breast cancer risk in women with certain high-risk breast conditions. The trial enrolled 65 women and compared short-term changes in breast tissue. However, the study was terminated early, so …

This small Phase 2 trial tested whether the antibiotic rifaximin could reduce bloating in people with diabetic gastroparesis, a condition where the stomach empties slowly. Only 5 participants were enrolled before the study was terminated early. The main goal was to measure change…

This study tested whether injecting a long-acting numbing drug (liposomal bupivacaine) during leg artery surgery could lower the amount of narcotics patients need during and after the procedure. The trial planned to enroll adults having elective lower extremity revascularization,…

This study tested a procedure called G-POEM, which uses a scope to cut the pylorus muscle, against a sham surgery in people with severe gastroparesis (stomach paralysis) that did not improve with medication. Only 3 patients enrolled before the study ended early. The goal was to s…

This study aimed to find the ideal dose of a spinal pain medicine (hydromorphone) for children undergoing back surgery for scoliosis. Researchers tested several doses in 31 patients to balance good pain control with fewer side effects. The trial was stopped early, so the results …

This study aimed to see if a paravertebral block (a type of nerve block) given before open Whipple surgery could reduce pain and hospital stay compared to no block. Only 2 people took part before the study was stopped early. The results are too limited to draw any conclusions.

This study tested a wearable armband called Nerivio that uses mild electrical pulses to reduce pain from Botox injections in people with chronic migraine. About 80 participants were planned, but the study was stopped early. The goal was to see if the device could make the injecti…

This study tested the antibiotic rifaximin (Xifaxan) to see if it could reduce stomach issues like bloating, pain, and diarrhea in people with early-stage HER2-positive breast cancer receiving pertuzumab-based chemotherapy. The trial planned to enroll 20 patients but was terminat…

This study tested a device called SinuSonic that uses sound vibrations and pressure to relieve sinus headache pain. The trial included 27 adults with facial pain lasting more than 3 months. Participants used either the real device or a sham device that looked the same but didn't …

This study tests whether a personalized exercise program (aerobic and resistance training) done before CAR-T therapy can improve physical fitness and quality of life in older adults (60+) with multiple myeloma that has returned or stopped responding to treatment. Twenty participa…

This study looked at why minority cancer patients often don't take part in clinical trials. Researchers surveyed patients about their understanding and attitudes, then tested an educational video and booklet to see if it boosted enrollment. The goal was to create a personalized p…

This study looked at whether adding a polygenic risk score (a genetic test) to standard breast cancer risk tools helps African American and Hispanic women make better decisions about screening and prevention. Researchers enrolled 19 women at higher risk for breast cancer. The stu…

This study tested whether a wearable device could help monitor patients after major surgery. Researchers wanted to see if patients would use the device and if the data could help predict problems. The study was stopped early, so it's unclear if the approach works.

This study tested a device called Brain4Care that measures pressure inside the skull without needing surgery. It included 6 adults with brain lesions who were at risk for worsening pressure. The goal was to see if the device is safe and effective for early detection of dangerous …

This study looked at whether the heart's pumping ability affects how quickly patients recover from muscle relaxants given during surgery. Researchers measured heart output and recovery time after using sugammadex to reverse the relaxant rocuronium. Only 7 people took part before …

This study tested whether a handheld electronic device called the Aeonose could tell if a person had been fasting just by analyzing their breath. Researchers collected breath samples from 879 adults before and after routine endoscopy procedures. The goal was to see if the device …

This study aimed to create a registry of tissue and blood samples from 1,000 patients undergoing surgery or biopsy for liver or bile duct tumors. The samples were stored for future research to better understand these cancers and develop new treatments. The study was terminated ea…

This study aimed to see how often people with chronic hepatitis C have a blood condition called monoclonal B-cell lymphocytosis (MBL), and whether treating hepatitis C affects MBL. Researchers planned to enroll 29 participants and compare blood samples before and after hepatitis …

This study looked at whether DNA markers found in urine can help detect prostate cancer. Researchers collected urine and prostate fluid samples from 24 men with or suspected of having prostate cancer. The goal was to see how accurate these markers are and to understand patient op…

This study looked at the genetics of people with multiple lung tumors (multifocal lung adenocarcinoma). Researchers collected tissue and blood samples from 100 participants during surgery to analyze their DNA. The goal was to see if genetic information could help guide treatment …

This study aimed to find genetic changes in lung tissue and blood that could predict how squamous cell lung cancer progresses. Researchers planned to collect samples from 200 patients undergoing lung procedures, but the study was stopped early with only 22 participants. No treatm…

This study aimed to find early markers of heart damage from chemotherapy in people with sarcoma. Researchers used advanced heart imaging (2D and 3D echocardiography) to track changes in heart function over time. The goal was to identify patients at highest risk for heart failure …