Mayo Clinic

This study is testing a new combination of four drugs for people newly diagnosed with multiple myeloma, a cancer of plasma cells. The goal is to find the safest and most effective dose and see how well the drugs work together to control the cancer. Researchers will closely monito…

This study aims to understand how two weekly injectable medications for obesity—semaglutide and tirzepatide—affect how the stomach works. Researchers will compare these drugs to a placebo in 30 adults with obesity, measuring stomach emptying, feelings of fullness, and body weight…

This early-stage study is testing whether stem cells taken from a patient's own body fat can safely reduce pain and improve function in arthritic hips. Researchers will inject either one or two doses of these processed cells directly into the hip joint of 24 adults with mild-to-m…

This early-stage study is testing whether combining a very precise form of radiation therapy with immunotherapy is safe and feasible for people with mesothelioma, a type of cancer. The goal is to see if this two-part approach can better control the cancer while causing fewer side…

This study is comparing two ways to surgically repair a specific type of knee cartilage tear. Researchers want to see if adding a 'centralization' step during surgery leads to better long-term results, less pain, and a lower chance of needing another surgery. The study will invol…

This study is testing whether a shorter, 3-week radiation schedule before surgery can reduce wound complications for people with soft tissue sarcoma in their arms, legs, or trunk. The trial involves 120 participants who will receive this condensed radiation treatment followed by …

This study is testing a shorter, 3-week course of radiation combined with chemotherapy for people with pancreatic cancer that hasn't spread. Researchers will monitor side effects and collect blood samples before and after treatment to check for cancer DNA. The goal is to see if t…

This study is testing a two-drug combination (pirtobrutinib and venetoclax) for people with previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The main goal is to see if using a sensitive blood test that detects tiny amounts of leftover c…

This study is testing a combination of two drugs, niraparib/abiraterone and prednisone, in men with advanced prostate cancer that has spread and has stopped responding to standard hormone-blocking treatments. The treatment is specifically for patients whose cancer has a particula…

This early-stage study is testing the safety and best dose of a new drug combination for advanced melanoma that has spread or cannot be surgically removed. It combines pembrolizumab, an immunotherapy drug, with ibrutinib, a drug that may block cancer cell growth. The goal is to s…

This study is testing a new two-part treatment for aggressive brain tumors that have returned or worsened. It aims to see if giving the drugs GI-102 and pembrolizumab just before surgery is safe and can help the immune system attack the tumor. The trial is for adults with specifi…

This study is testing a new protective case designed to cover the ends of dialysis catheters. Researchers want to see if it is more comfortable and easier to use than the traditional gauze and tape method. The goal is to reduce the risk of infections and accidental dislodgement f…

This early-stage trial is testing whether a patient's own immune cells can be grown in a lab to fight multiple myeloma that has returned or stopped responding to other treatments. Doctors take T-cells from the patient's blood, grow them to target a specific protein found on cance…

This Mayo Clinic study is testing whether a special fish skin graft can help close anal fistulas (abnormal tunnels) and related non-healing wounds. Researchers will enroll 20 adults with these conditions to see if the treatment stops drainage and infection. The goal is to determi…

This study aims to measure whether stem cell transplants can slow or stop the progression of CSF1R-related leukoencephalopathy, a rare genetic brain disease. Researchers will follow 20 adult patients who have the genetic mutation and are scheduled to receive a transplant. They'll…

This early-stage study is testing if adding a new drug called parsaclisib to a standard chemotherapy regimen (R-CHOP) is safe and more effective for patients with newly diagnosed, high-risk diffuse large B-cell lymphoma. The main goals are to find the safest dose of the new combi…

This early-stage study is testing whether a patient's own fat-derived stem cells can be safely delivered directly into the arteries supplying the colon to treat ulcerative colitis. It involves 20 adults with moderate-to-severe disease that hasn't improved with at least two standa…

This early-stage trial is testing the safety and best dose of a specially engineered virus designed to infect and kill endometrial cancer cells while sparing healthy ones. The virus can be tracked in the body using imaging. Some participants also receive an oral drug that may hel…

This study aims to find out if operating on brain tumors earlier—after initial treatment but before they visibly return—is safe and more effective than waiting. It will compare outcomes for 40 adults who have this early surgery against those who have surgery at a different time o…

This early-stage study is testing whether stem cells taken from a patient's own body fat can help keep their dialysis access point from failing. The cells are applied during the surgery to create the access point. The goal is to see if this approach is safe and can improve how we…

This study is testing if semaglutide, a medication used for weight loss, can improve heart function and reduce symptoms in people who are obese and have a type of heart failure where the heart pumps normally but doesn't relax properly. About 81 participants will be randomly assig…

This study tests whether giving drug combinations before surgery can help people with high-risk stage III melanoma. The trial involves 59 participants receiving either targeted cancer drugs, immunotherapy drugs, or both for several weeks before their operation. Researchers want t…

This study is testing if a shorter, more intense course of radiation is safe and effective for men whose prostate cancer has returned or spread to a few lymph nodes. It compares two radiation methods—proton therapy and standard IMRT—to see which one causes fewer serious side effe…

This study aims to see if using ketamine instead of propofol to put patients to sleep at the start of complex heart surgery better protects their kidneys from injury. It will involve 200 adults undergoing major heart procedures at Mayo Clinic. Researchers will compare how often k…

This study is testing a specific surgical repair technique for a serious type of knee cartilage tear called a meniscus root tear. It will follow 55 adults to see if the surgery improves their activity levels and knee function. Researchers also want to find out if this repair can …

This study is testing whether a drug called metyrapone can safely and effectively treat a condition where the adrenal glands produce too much cortisol, a stress hormone. It will enroll 30 adults diagnosed with this mild cortisol excess who also have related health issues like hig…

This study aims to find the best strategy to protect heart function in breast cancer patients receiving trastuzumab treatment, which can sometimes weaken the heart. Researchers are testing whether to give the heart-protecting drug carvedilol preventively before treatment starts, …

This study is testing whether estradiol, a form of estrogen, can help control advanced triple-negative breast cancer that has a specific biomarker called ER beta. Researchers are giving estradiol pills to 8 postmenopausal women whose cancer has spread and seeing if their tumors s…

This study compares two radiation treatments given after breast cancer surgery. It tests whether a newer, shorter proton beam treatment (5 sessions) causes fewer complications than standard x-ray therapy (25 sessions). The trial involves 146 women with early to mid-stage breast c…

This study is testing whether giving vitamin D supplements to cancer patients who have low vitamin D levels can help improve their survival and delay the need for other treatments. It focuses on people newly diagnosed with certain aggressive lymphomas or a slow-growing type of le…

This study is testing whether a shorter course of antibiotics combined with a medication called octreotide works as well as longer antibiotics after pancreatic surgery. Researchers want to see if this approach reduces hospital stays and prevents a common complication called pancr…

This study follows 2,480 people with narrowed neck arteries for up to 10 years to see which approach best prevents strokes long-term. Participants previously joined a trial comparing artery surgery, stenting, or intensive medication management. Researchers will call participants …

This study is testing whether improving sleep habits can help control high blood pressure. It involves 110 adults with prehypertension or mild stage 1 hypertension who regularly sleep 6.5 hours or less per night. Participants will either follow an 8-week program to extend their s…

This early-stage study is testing a new combination of two drugs, sonidegib and pembrolizumab, for people with advanced solid tumors that have spread. The main goals are to find the safest dose of the combination and see if it helps shrink or control the cancer. The study is enro…

This study is testing whether transplanting a donor voice box (larynx) is a safe and effective way to help people with severe, untreatable damage to their own. It will involve 10 adults who have lost normal voice, swallowing, or breathing function, often due to cancer treatment o…

This small Mayo Clinic study is testing whether a nightly automated neck massage device can help improve the brain's natural waste-clearing system in people with treated sleep apnea. Researchers will measure changes in blood markers linked to brain health and sleep quality after …

This study is testing whether adding a new experimental drug, TVB-2640, to standard treatments can help control advanced HER2-positive breast cancer that has spread and is no longer responding to the usual therapies. It involves a small group of patients whose cancer has progress…

This is a first-in-human study to find a safe dose of an experimental pill called WSD0922-FU for people with aggressive brain tumors or lung cancer that has spread to the brain. The pill is designed to block a specific protein (EGFR) that drives these cancers and may be able to r…

This study is testing a new combination of drugs for people with multiple myeloma, a blood cancer, that has come back and stopped responding to standard treatments. The main goals are to find the safest dose of the new drug selinexor when combined with other cancer drugs, and to …

This small pilot study is testing whether a specially designed, low-calorie, high-protein liquid food given through a feeding tube can help obese patients who rely on tube feeding to lose weight. The study will also check if the formula is well-tolerated and if it improves other …

This study compares two treatments for adults with severe fecal incontinence (bowel leakage). First, all participants try a 4-week program of education, diet changes, and exercises. If that doesn't help enough, they are randomly assigned to receive either biofeedback training (to…

This study is testing whether stem cells taken from a patient's own fat tissue and injected into their spinal fluid can slow the progression of multiple system atrophy (MSA), a rare and fatal neurological disease. Researchers are comparing two different dosing schedules against a…

This study is testing a procedure called MR-guided cryoablation to treat prostate cancer that has returned after initial treatment. It uses an MRI to precisely guide a probe that freezes and destroys the tumor. The goal is to see if this freezing technique is safe and effective f…

This study is testing whether the drug sotatercept, taken for 36 weeks, improves how the heart and lungs work together during exercise in people with pulmonary arterial hypertension. Researchers will measure heart function, blood flow, and oxygen delivery in 30 participants while…

This study is testing the safety and basic function of a new brain implant system for people with severe, hard-to-treat epilepsy. The device senses brain activity, uses a computer program to predict seizure risk, and can deliver small electrical pulses to try to prevent seizures …

This study is testing if a widely used cholesterol-lowering drug, atorvastatin (Lipitor), can safely improve liver health in adults with NASH, a serious form of fatty liver disease that can lead to scarring. About 70 participants with confirmed liver damage will receive either th…

This study is testing a combination of four chemotherapy drugs to treat a more aggressive form of multiple myeloma, a blood cancer. The main goal is to see if this treatment can make the cancer undetectable in blood tests and keep it that way for at least a year. It is for newly …

This study is testing whether a small, mesh device called a Coronary Sinus Reducer can help patients with a specific type of heart failure where the heart pumps normally but is too stiff to fill properly. The device is implanted in a vein of the heart to reduce pressure and impro…

This study is testing whether combining two drugs, durvalumab and lurbinectedin, can help control a fast-growing type of lung cancer that has returned or stopped responding to standard treatments. It aims to see if this combination can help patients live longer without their canc…

This study is testing a new treatment for ovarian, fallopian tube, or primary peritoneal cancer that has come back after standard therapy. Doctors are using a specially engineered measles virus, which is carried directly to the cancer by the patient's own fat-derived stem cells, …

This study is testing whether a gentle, non-invasive brain stimulation technique can increase blood flow to the brain. It aims to see if this improved blood flow can help people with certain brain vessel conditions who are experiencing problems with memory and thinking. The study…

This study is testing whether stem cells taken from a patient's own body fat can help improve movement and feeling in people paralyzed by a traumatic spinal cord injury. Doctors inject these specially grown cells into the spinal fluid of 40 adults to see if they are safe and can …

This study is testing two different ways of prescribing high-intensity interval training (HIIT) to see which is better for improving fitness and heart health in people doing cardiac rehabilitation. It involves 30 adults who have had a heart event like a heart attack or stent plac…

This study compares two standard surgical approaches for treating infected hip or knee replacements. Researchers want to know if performing one thorough cleaning surgery works as well as planning two separate cleaning surgeries, followed by long-term antibiotics. The trial involv…

This study is testing whether combining two existing drugs can help control advanced salivary gland cancer. It is for adults whose cancer has come back after treatment or has spread to other parts of the body. The goal is to see if the combination of a chemotherapy drug (pemetrex…

This early-stage study aimed to test if a drug called AEO could help protect or restore normal brain function after standard radiation treatment for brain cancer. The trial planned to enroll adults with brain tumors who were scheduled for or had recently completed radiation. It w…

This study tests a Minnesota program designed to help workers who get injured or sick stay employed and avoid long-term disability. The program provides early support and workplace accommodations to employees who might otherwise leave their jobs. Researchers are tracking whether …

This early-phase trial is testing the safety and best dose of a two-drug combination (selinexor and choline salicylate) for adults with advanced blood cancers that have returned or stopped responding to standard treatments. The study includes patients with non-Hodgkin lymphoma, H…

This study compares two different surgical approaches for fixing broken thigh bones near the knee. Researchers are testing whether using two metal implants works better than using just one implant. They're measuring recovery time, complications, and how long patients stay in the …

This study is testing whether a virtual reality-based cardiac rehabilitation program is practical and safe for heart patients to use from home. It involves a small group of eligible adults who have had recent heart events like a heart attack or surgery. The main goals are to see …

This study is looking at how well two FDA-approved ablation procedures work for controlling Barrett's esophagus, a condition that can lead to esophageal cancer. Researchers will follow 600 patients who have received or qualify for these treatments to see if Barrett's tissue retur…

This study is testing whether a short, two-day course of a compound called fisetin can help people with advanced chronic kidney disease. Researchers want to see if fisetin can reduce body-wide inflammation, improve the function of certain repair cells, and help with physical stre…

This study is comparing a new, shorter radiation schedule to the standard, longer one for treating glioblastoma, an aggressive brain cancer. Researchers want to see if the shorter treatment, which delivers higher doses over 1-2 weeks, works as well as the standard 3-6 week treatm…

This study is testing whether very low doses of radiation, guided by special brain scans, can slow the progression of Parkinson's disease. Researchers will give five radiation treatments to 20 participants with early-stage Parkinson's and measure changes in their movement symptom…

This study aims to develop personalized drug treatments for people with rare genetic diseases that currently have no good treatment options. Researchers will work with 50 participants to create custom drugs that target the specific genetic causes of their conditions. The study in…

This study is testing whether stem cells taken from a patient's own body fat and injected into the fluid around their spine can safely slow the progression of ALS. Over 12 months, 75 participants at Mayo Clinic will receive four injections to see if this treatment helps maintain …

This study is testing whether a proven therapy for youth eating disorders can be successfully delivered by primary care doctors. It involves 200 children and teens with restrictive eating disorders and their caregivers. The goal is to make this effective treatment more widely ava…

This small, early-stage study is testing whether stem cells taken from a patient's own body fat can help heal serious pressure sores or diabetic foot ulcers. Doctors take a small amount of fat via liposuction, extract the stem cells, and apply them directly to the wound. The main…

This Mayo Clinic pilot study aims to see if eating all your daily food within an 8-hour window earlier or later in the day is better for weight loss. It will involve 100 overweight or obese adults. The study will track changes in weight, BMI, blood sugar, and cholesterol, while a…

This small, early-stage study is testing whether two drugs (Dasatinib and Quercetin) can be safely given to people with Alzheimer's disease or mild cognitive impairment. The drugs aim to clear out 'senescent' or aging cells that may contribute to brain decline. Researchers will m…

This early-stage study is testing a new type of marker designed to help surgeons locate cancerous lymph nodes more easily during breast cancer surgery. The marker is placed in the lymph node before treatment and surgery. Researchers want to see if it stays visible on ultrasound a…

This study is testing a new type of MRI scan to see if it can accurately detect and measure scarring (fibrosis) in kidneys. The research involves 24 adults with high blood pressure and kidney artery narrowing. The goal is to see if this non-invasive scan can reliably predict whet…

This study aimed to test a new, non-invasive device called the LabClasp to see if it could accurately estimate blood lactate levels without a needle stick. It planned to test the device on two groups: healthy adults during exercise and critically ill patients in the ICU. The stud…

This study aims to find better ways to check for heart damage in adults who have finished chemotherapy for cancer. Researchers are testing if a simple AI analysis of a heart tracing (ECG) or a blood test can reliably detect a weakened heart pump. The goal is to gather data to pla…

This study aims to see if a special brain scan called DaTSCAN can help doctors better understand and diagnose conditions like dementia, Parkinson's disease, and mild memory problems. Researchers will scan 500 adults aged 40-90 who have one of these conditions and compare the scan…

This study is testing a new type of heart scan called magnetocardiography (MCG) to see if it can quickly and accurately tell if a patient's chest pain in the emergency room is caused by a heart attack or reduced blood flow to the heart. Researchers will compare the MCG scan resul…

This study is testing a new needle guide device designed to help doctors place biopsy needles more accurately during MRI-guided prostate procedures. It aims to see if the special grid helps the needle hit the exact target area in the prostate. The study is enrolling about 20 men …

This study is testing whether artificial intelligence (AI) can accurately detect a serious heart condition called hypertrophic cardiomyopathy (HCM) using ECG readings from consumer devices like the Apple Watch and KardiaMobile. Researchers are comparing the AI's performance on th…

This study is testing a new technology called DESI-MS to see if it can help surgeons during brain tumor operations. The goal is to quickly tell the difference between healthy brain tissue and cancerous tissue right in the operating room. This could help surgeons remove tumors mor…

This study is testing whether using an Apple Watch for long-term heart monitoring can help find hidden atrial fibrillation (an irregular heartbeat) in people at high risk for stroke. It will enroll 2,000 adults who show signs of possible hidden AFib on a special AI analysis of th…

This study is developing an AI-powered system to measure pain objectively using body signals, rather than relying on patients' self-reporting. It involves 70 adults recovering from outpatient plastic surgery at home. Researchers hope this technology will help personalize pain med…

This study is testing if a special type of PET scan (using a tracer called 18F-DOPA) can help doctors more accurately plan radiation treatment for malignant brain tumors. It will compare the radiation target areas identified by this new scan with those from the standard MRI scan.…

This study is testing whether a special type of MRI scan, called MR elastography, can accurately measure high pressure inside the skull. Researchers are comparing this scan to other non-invasive methods like eye imaging and ultrasound to see which is best at detecting the problem…

This study aims to find better ways to diagnose concussions on the spot and set safer rules for when athletes can return to play. Researchers will test whether a new blood test can detect concussion and if special neck and vision training can help prevent these brain injuries. Th…

This study is testing a new type of MRI scan called MR Elastography to see if it can better identify and measure myofascial pain. Researchers will compare scans from 106 people with chronic low back or leg pain to scans from healthy volunteers. The goal is to create a more object…

This study is testing a new, simpler way to screen for Barrett's esophagus and esophageal cancer. Researchers are using a small sponge on a string that patients swallow, which collects cells from the esophagus. They are checking if lab tests on these cells can accurately spot dan…

This study aimed to validate a faster genetic test for pregnant women whose babies showed signs of possible genetic disorders. It planned to compare results from a new test on amniotic fluid with standard blood tests. The goal was to speed up diagnosis to help guide care for the …

This study aims to find new chemical markers in the blood and urine that could help detect kidney and bladder cancers. Researchers are collecting samples from 589 people, including those with these cancers and healthy individuals, to compare and identify reliable markers. The goa…

This study is testing a special type of ultrasound to measure stiffness in the wrist before and after carpal tunnel treatment. Researchers want to see if this scan can help doctors better track how well injections or surgery are working. The study involves 20 adults who are alrea…

This study is testing a new type of imaging scan to see if it can better identify and map pediatric neuroendocrine tumors, which are rare cancers. Researchers want to know if this new scan helps doctors more precisely target radiation therapy compared to the standard scan current…

This study tests whether a short course of two drugs can prevent hepatitis C from spreading when an organ from an infected donor is transplanted into an uninfected patient. It involves 200 kidney, heart, lung, or pancreas transplant recipients who agree to accept an organ from a …

This study offers an experimental procedure to freeze ovarian tissue from girls (newborn to 17 years old) who face medical treatments like chemotherapy that could leave them infertile. The goal is to preserve the tissue so it might be used in the future to help them get pregnant …

This study is testing a new approach to prevent stomach cancer from returning to the abdominal cavity after surgery. During the operation, doctors will wash the abdomen with a warm chemotherapy solution. The goal is to kill any stray cancer cells left behind to prevent the cancer…

This study is testing whether offering easy-to-use, at-home HPV swab kits at walk-in clinics with evening and weekend hours can help more women get screened for cervical cancer. It will involve 500 women aged 30-63 who are overdue for their regular screening. Researchers will com…

This study is testing whether a widely available probiotic supplement can prevent a serious and painful side effect of cancer immunotherapy. It involves 12 adults with solid tumors who are receiving immunotherapy, which can cause severe colon inflammation and diarrhea in nearly h…

This study aims to measure how much a thyroid radiofrequency ablation procedure improves symptoms in patients with thyroid nodules. Researchers will track 300 patients using a symptom questionnaire before and after their treatment. The goal is to better understand how effectively…

This study is testing whether a special high-flow oxygen device helps patients with higher body weight recover faster after endoscopic ultrasound procedures. Researchers want to see if this oxygen method reduces recovery time and makes the procedure go more smoothly compared to s…

This study is testing whether virtual behavioral health follow-up care can help people with fibromyalgia better manage their symptoms and improve daily life. Researchers are enrolling 300 patients from Mayo Clinic's fibromyalgia clinic to compare the virtual program against usual…

This study is testing whether using a footstool to change your posture on the toilet can help relieve constipation. Researchers at Mayo Clinic are comparing a 7-inch footstool to a shorter, 2-inch sham device to see which one better improves bowel movement frequency and symptoms.…

This study aims to find the safest and most effective number of steroid (dexamethasone) doses to give around the time of knee replacement surgery. Researchers will compare giving one, two, or three doses to see which best reduces pain, cuts down on the need for strong opioid pain…

This study is testing whether a drug called fisetin can help prevent hospitalized COVID-19 patients from getting sicker. Researchers want to see if it can reduce dangerous inflammation and help patients breathe easier without needing more oxygen or a ventilator. The trial include…

This study is testing a wrist-worn device called Cala TWO that aims to reduce hand tremors in people with essential tremor. The device works by delivering gentle electrical stimulation to nerves in the wrist. Researchers are measuring how well it helps with daily activities and t…

This study is testing a new plastic clamp designed to help clear fluid from surgical drain tubes. The goal is to see if it's easier for nurses to use and if it helps reduce complications compared to the current method of using fingers. The study will gather feedback from about 80…

This study aims to see if using a smaller ureteral stent after kidney stone surgery reduces pain and discomfort. Researchers will follow 100 patients who have a stent placed after their procedure, contacting them daily to track their pain levels. The goal is to find out if stent …

This Mayo Clinic study is testing whether using virtual reality (VR) can help reduce anxiety, depression, and emotional distress in patients receiving palliative care. It involves about 20 adult patients with a terminal illness who are expected to live a year or less. The researc…

This study aimed to see if a special therapy called blood flow restriction could help people recover faster after surgery for a torn knee ligament or bicep tendon. It planned to measure if patients regained strength and movement more quickly. However, the study was withdrawn befo…

This small pilot study is testing whether a non-invasive electromagnetic therapy can help people with painful foot or ankle arthritis. Researchers at Mayo Clinic are measuring if the treatment reduces pain and improves daily activities like walking. The study involves 20 particip…

This study is testing two ways to manage pain for people having surgery for thoracic outlet syndrome, a condition causing arm and shoulder pain. Researchers want to see if receiving a pain-numbing injection before surgery AND after surgery works better than just getting it before…

This small study is testing whether using virtual reality headsets can help patients feel more comfortable during heart rhythm procedures. Researchers want to see if the VR distraction reduces anxiety and the need for sedative medications. The study will also check if patients li…

This study is testing which of two advanced prosthetic hands—the SoftHand Pro or the Ossur i-Limb—helps people with below-elbow limb loss perform everyday activities better. Over an 8-week period, 36 participants will use each device in their daily lives. Researchers will measure…

This Mayo Clinic study compares how two different procedures for draining blocked bile ducts affect patients' quality of life. Researchers are looking at 206 people with both cancerous and non-cancerous blockages who receive either endoscopic or percutaneous drainage. The goal is…

This study aims to find out if removing ureteral stents three days after kidney stone surgery is as safe and effective as the standard seven days. Researchers will compare symptoms, pain levels, and recovery time in 172 patients to see if earlier removal reduces discomfort withou…

This Mayo Clinic study is testing whether a virtual reality meditation program can help reduce the overall impact of fibromyalgia symptoms. Forty adults with fibromyalgia will try both an active VR meditation program and a sham (fake) VR experience to see which one helps them fee…

This study is testing whether the way patients are taught about their upcoming ACL knee surgery affects how satisfied they are, how anxious they feel, and how well they recover. About 105 patients at Mayo Clinic Arizona are being randomly assigned to receive different types of ed…

This study aimed to see if the type of stitch used to close a wound after common hand surgeries (like carpal tunnel or trigger finger release) made a difference in how the scar looked and how satisfied patients were. It planned to compare stitches that dissolve on their own with …

This study tests an 8-week online group therapy program designed to help caregivers of advanced cancer patients. The program aims to help caregivers find meaning and purpose in their caregiving role, which may reduce feelings of distress, burden, and despair. Researchers will see…

This small pilot study from Mayo Clinic is testing whether using virtual reality (VR) is safe and tolerable for people with gastroparesis, a condition where the stomach empties too slowly. Thirty adult participants will try either an active VR program or a sham (fake) VR program …

This study is testing whether a 10-week home exercise program, delivered remotely via video calls, can improve physical function and quality of life for survivors of early-stage endometrial cancer. It focuses on participants who live in rural areas or are from historically unders…

This study is testing if a small change during knee replacement surgery can help reduce pain afterwards. Researchers are comparing two ways of handling a specific nerve in the knee. One method is the standard approach; the other involves tucking the nerve end into soft tissue to …

This study compares two ways to prepare for prostate cancer radiation therapy: coming with a full bladder or an empty bladder. The standard method requires a full bladder, but this can be difficult for patients to maintain and may cause stress. Researchers want to see if using an…

This study is testing whether using virtual reality (VR) goggles during knee or hip replacement surgery can help patients feel less anxious and need less medication. About 50 patients having surgery with regional anesthesia (numbing a large area) will try VR during their procedur…

This study aimed to test whether a biofeedback device called JOGO could help reduce tremors in people with functional neurological disorder. The device uses wireless stickers to monitor muscle activity and provides feedback to help patients learn to control their shaking through …

This study is testing whether injections of donor stem cells into the spine's facet joints can safely reduce chronic low back pain. It will involve 40 adults who have had back pain for at least 6 months that hasn't improved with standard treatments like physical therapy or medica…

This study compares two pain medication approaches for people recovering from knee or hip replacement surgery. Researchers want to see if combining tramadol and oxycodone works better than oxycodone alone to control pain while reducing overall opioid use and side effects like nau…

This study is testing a special wearable headset designed to reduce the motion sickness people sometimes feel when using virtual reality (VR). The device uses gentle electrical stimulation to help the user's balance system better match what they're seeing. Researchers are measuri…

This small, early-stage study is testing whether a natural plant compound called fisetin can help reduce frailty in older women. Researchers will give fisetin or a placebo to 40 healthy women aged 70 and over to see if it improves their walking speed and reduces signs of inflamma…

This study is testing whether a smartphone app that analyzes a person's voice to detect signs of depression and anxiety can help improve mental health for people recovering from a heart attack. The app is being used alongside standard cardiac rehabilitation to see if it leads to …

This study is testing whether a non-invasive electromagnetic therapy can help men recover bladder control faster after prostate surgery. It will involve 2,100 men who have had surgery and are experiencing urine leakage. The main goal is to see if this technology shortens recovery…

This Mayo Clinic study is testing whether a home-based brain stimulation device, combined with daily activities, can help people recover thinking and language skills after a stroke, brain tumor, or neurodegenerative disease. The research aims to see if this approach is practical …

This study is testing whether a natural compound called fisetin can help reduce frailty and signs of inflammation in the blood of older adults. Researchers at Mayo Clinic are enrolling 40 participants aged 70 and older to see if taking fisetin improves markers of frailty, inflamm…

This study compares two numbing medicines for pain relief after surgery to remove an eye. Researchers want to see if a new slow-release injection provides better, longer-lasting pain control than the standard injection. The trial involves 88 adults having eye removal surgery at M…

This small study is testing if a gentle, non-invasive brain stimulation technique called tDCS is practical and acceptable for hospitalized adults with severe depression that hasn't responded to other treatments. Over five days, participants receive short stimulation sessions whil…

This study aims to see if there is a difference in the amount of metal that gets into a patient's bloodstream after two different types of knee replacement surgery. Researchers are comparing the newer robotic-assisted surgery with the traditional method using cutting guides. They…

This study uses specialized brain scans (PET scans) to see if anti-amyloid Alzheimer's drugs also reduce tau protein tangles in the brain. Researchers will follow 135 patients with mild Alzheimer's symptoms who are already receiving these therapies at Mayo Clinic. The goal is to …

This study aims to better understand how amino acids (building blocks of protein) affect the release of two key hormones—glucagon and insulin—that control blood sugar. Researchers are comparing how people with type 2 diabetes, people with obesity, and healthy individuals respond …

This study aims to understand how Vitamin D from a mother's daily supplement passes into her breastmilk and is then processed by her baby. Researchers are measuring Vitamin D levels in breastmilk before and after 28 days of supplementation in 60 breastfeeding mothers. They are al…

This study aims to measure and understand the levels of moral distress, moral injury, and post-traumatic stress symptoms among nurses at Mayo Clinic. Researchers will survey over 21,000 nursing staff members to identify which workplace settings, specialties, and personal factors …

This study aims to understand the normal range of immune responses in healthy children after they receive routine vaccinations. Researchers will collect small blood samples from 300 children before and after their scheduled shots to measure various immune markers. The goal is to …

This study compares two medical devices that monitor nerve function during surgery when patients' arms are tucked at their sides. Researchers will test both devices on 40 patients undergoing cystoscopy procedures to see which provides more accurate measurements. The goal is to im…

This study aims to understand if excessive use of social media apps on smartphones can worsen anxiety symptoms. Researchers are enrolling 100 adults who experience mild anxiety and use social media regularly. The goal is to gather information about smartphone habits and mental he…

This study aims to understand how and why the breast cancer drug T-DM1 causes nerve damage (peripheral neuropathy) in patients. Researchers will observe 36 patients with HER2-positive breast cancer who are receiving T-DM1 treatment. They will track changes in nerve-related sympto…

This study aims to understand cancer screening awareness and barriers among incarcerated women. Researchers will survey 1,200 women at a Florida prison to learn about their knowledge, screening history, and challenges. The information will be used to create a digital education pr…

This study aims to understand if long-term weightlifting is linked to an enlarged aorta, a major heart blood vessel. Researchers will check the aorta size in 45 experienced weightlifters over age 35 using heart ultrasound scans. The goal is to gather information, not to test a tr…

This study aims to understand if certain markers found in lymph node tissue can predict how well a patient does after an organ transplant. Researchers will analyze previously collected tissue samples from 200 adults who have undergone transplant surgery. The goal is to gather kno…

This study is collecting samples like blood, tissue, and DNA from 5,000 people with rare or undiagnosed diseases. Researchers will store these samples in a biobank to study them and look for genetic causes of these conditions. The goal is to help diagnose patients and find potent…

This Mayo Clinic study aims to collect detailed health data from 10,000 existing patients to better understand how genetics and environment influence health and disease. Participants will provide samples and health information to build a large research database. The goal is to he…

This study is testing whether personalized education and genetic counseling can encourage more people with a family history of pancreatic cancer to get genetic testing. Researchers are working with 40 patients at Mayo Clinic Florida who have a close relative with pancreatic cance…

This study is testing the safety of a new type of electronic bandage that makes hydrogen peroxide, which could one day help treat or prevent wound infections. Researchers are applying small versions of this bandage to the healthy skin of 40 volunteers to check for any skin irrita…

This Mayo Clinic study aims to understand if long-term inflammation in the body increases a woman's risk of developing endometrial (uterine) cancer. Researchers are collecting blood, urine, and tissue samples from 191 women who are having a hysterectomy, either for cancer or for …

This study aims to understand how radiation therapy affects skin blood flow in breast reconstruction patients. Researchers will use a special ultrasound to measure blood supply in the skin before and after a fat grafting procedure. The goal is to gather information that may help …

This study aims to understand if specific inherited gene changes make some people more likely to develop painful kidney stones. Researchers will compare genetic and health information from about 1,800 people with a history of kidney stones to 900 people without stones. The goal i…

This study aims to learn if simple blood tests can help doctors personalize radiation treatment for breast cancer. Researchers are tracking tiny cancer DNA fragments and immune cells in the blood of 217 patients before, during, and after their radiation therapy. The goal is to se…

This study aims to understand how genetic changes in prostate cancer tumors relate to treatment response. Researchers collect tissue, blood, and urine samples from 92 men with advanced prostate cancer before and during standard treatment. By analyzing these samples, they hope to …

This study is building a collection of blood, stool, and urine samples, along with health information, from people with and without Inflammatory Bowel Disease (IBD). Researchers will use this 'biobank' to learn more about what causes IBD and how it progresses. The goal is to gath…

This study is testing a new blood test to see if it can find tiny pieces of HPV DNA from cervical cancer in the bloodstream. Researchers want to see if this test can help predict how well treatment is working and detect if the cancer comes back earlier than current methods. The s…

This study is testing a new type of brain implant system to see if it can detect very early, specific brainwave patterns that happen before an epileptic seizure. Researchers will use the device externally (not implanted) on 12 people with drug-resistant epilepsy to see if it can …

This study is collecting saliva, blood, and tissue samples from 100 adults with lymphedema to store for future research. The goal is to discover biological markers that could help doctors better understand the disease and optimize future surgical treatments. Participants are not …

This study is testing whether a special ultrasound technique can create detailed pictures of tiny blood vessels in the kidneys. Researchers want to see if this imaging method works better than current approaches for understanding chronic kidney disease. The study includes both he…

This study aims to understand how chemotherapy given before breast cancer surgery affects patients' immune systems. Researchers will collect blood samples from 38 participants with operable breast cancer at different points during their treatment. The goal is to learn how the imm…

This study aims to see if a simple, non-invasive test that looks at tiny blood vessels under the fingernails (nail fold capillaroscopy) can help doctors understand why some people develop a stomach condition called GAVE. Researchers will compare the nail test results in 75 adults…

This study aims to find early warning signs in blood and urine that can predict how quickly a genetic kidney disease will worsen. Researchers will collect samples and perform an MRI scan from 100 patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). The goal is to i…

This study aims to see if providing a personalized genetic risk score helps women at high risk for breast cancer make more informed decisions about taking preventive medication. It involves 737 women who will receive their genetic risk score during a standard consultation and the…

This study aims to see if eating a diet high in fermented foods like yogurt, kefir, and kimchi can change the mix of bacteria in the gut (the microbiome) of people with long COVID. Researchers at Mayo Clinic will enroll 40 adults with long COVID and randomly assign half to eat 6+…

This Mayo Clinic study aims to understand how a mother's emotional state, sleep quality, and diet might influence two important substances in her breast milk: melatonin (related to sleep) and sIgA (an immune protein). Researchers are enrolling 120 new mothers to provide a small b…

This study aims to understand if the body's bile acid system responds differently to weight loss from gastric bypass surgery compared to weight loss from a low-calorie diet. Researchers at Mayo Clinic are observing 21 adults with severe obesity, measuring bile acids in stool and …

This study aims to find out how common certain genetic changes are in kidney transplant patients. These changes can increase the risk of cancer and other diseases. Researchers will test patients' genes and see if the results lead doctors to recommend different cancer screening pl…

This study aims to understand how immigration experiences affect prostate cancer care decisions and survivorship for men from Sub-Saharan Africa and the Caribbean. Researchers will interview 80 immigrant men who have been diagnosed with prostate cancer to learn about their health…

This Mayo Clinic study aims to learn how the health of 500 acutely ill patients changes over time while they are in a special hospital monitoring unit. Researchers will closely track vital signs like heart rate and blood pressure to see how they shift when a patient's condition w…

This study follows up with 140 patients from a previous breast cancer trial (BEAUTY) to learn more about how cancer responds to treatment over time. Researchers will collect blood samples and health information to understand why some cancers come back and others don't. The goal i…

This Mayo Clinic study is testing whether training primary care doctors in communication skills or providing patient-experience coaching leads to higher patient satisfaction and reduces doctor burnout. The study involves 45 clinicians who complete surveys about their job satisfac…

This study aims to understand the biological processes that control how children's limbs grow. Researchers will analyze small tissue samples taken during routine orthopedic surgeries from up to 100 children and young adults. The goal is to identify molecules that could one day be…

This study aims to understand how bone marrow cells in people with a blood condition called MGUS use nutrients from their surroundings compared to healthy people. Researchers will collect blood and bone marrow samples from 40 participants—some with MGUS and some healthy volunteer…

This study aims to understand how often seizures occur in people with early-onset Alzheimer's disease. Researchers at Mayo Clinic are monitoring 20 participants using a portable EEG device worn for 48 hours to detect brain activity patterns. The goal is to gather information abou…

This study is collecting information from healthy adults to compare with people who have congenital heart disease. Researchers want to understand how heart function differs between healthy people and those with heart conditions. The study involves 66 healthy participants who will…

This study aims to collect tissue samples, blood, and medical information from 300 patients with advanced breast cancer that has spread. Researchers will analyze these samples to understand why breast cancer spreads to other parts of the body and why different patients respond di…

This study aims to understand if immunotherapy treatments for cancer affect a patient's balance and hearing. Researchers will follow 50 adults who are starting specific immunotherapies as part of their standard cancer care. They will compare balance and hearing tests done before …

This study is collecting health information and blood or tissue samples from family members of people with pancreatic cancer or melanoma. The goal is to create a research database to help scientists understand if certain cancers can run in families. Over 1,100 participants have c…

This study aims to understand how the benefits of deep brain stimulation for essential tremor change throughout the day. Researchers will have 50 patients already receiving this treatment wear Apple Watches while performing specific tasks to collect movement data. The goal is to …

This study aims to screen 1,000 adults for a blood condition called MGUS, which can sometimes develop into a blood cancer. Researchers want to understand how common MGUS is and learn about the genetic and immune factors linked to it, especially across different ancestral groups. …

This study aims to understand how using a person's genetic information can impact their healthcare. It will enroll 110,000 Mayo Clinic patients to sequence their DNA and link that data to their health records. The goal is to see if this genetic information can help with disease p…

This study aims to understand how a single session of exercise changes the cells and signals in body fat (adipose tissue). Researchers are studying 56 healthy and obese adults, both young and older, to see how their fat tissue responds during and after cycling. The goal is to lea…

This Mayo Clinic study aims to find out if the types of bacteria living in a person's gut are linked to their risk of heart disease. Researchers will collect blood and stool samples from 700 adults who are already scheduled for a heart catheterization test. By comparing the gut b…

This study aims to understand if taking a daily nicotinamide riboside supplement for 12 weeks improves blood vessel health in healthy adults. Researchers will measure changes in blood vessel stiffness in 200 participants aged 35 to 70. The goal is to gather knowledge that could i…

This large Mayo Clinic study aims to understand how genes and environment contribute to disease, with the goal of predicting and preventing illness before it becomes serious. It will enroll 100,000 existing Mayo Clinic patients to collect samples, voice recordings, and survey dat…

This study aims to better understand how two proteins, amyloid and tau, build up in the brains of people with different forms of Alzheimer's disease. Researchers will use brain scans to track 60 participants with typical or unusual Alzheimer's symptoms over one year. The goal is …

This study aims to understand how to best implement a digital health app that helps primary care doctors screen for substance use issues and connect patients to treatment. It will enroll 60 participants from Mayo Clinic primary care sites who are at risk for substance use disorde…

This study aimed to understand how the heart muscle changes shape and size after a heart attack. Researchers followed 1,599 people from specific Minnesota counties who had a recent heart attack. The goal was to learn which patterns of heart change are linked to developing heart f…

This study aims to understand why minority and underserved cancer patients often do not join clinical trials. Researchers are surveying patients about their knowledge and attitudes, then testing a personalized educational platform designed to provide clear information and support…

This study aims to better understand why pancreatic cancer runs in families by tracking 3,000 people who have relatives with the disease but don't have cancer themselves. Participants complete health questionnaires every two years and may provide a one-time blood sample. The goal…

This study aims to understand how getting genetic test results affects people's healthcare. Researchers will follow 100,000 adults who have already taken a specific genetic test, tracking their doctor visits, hospital stays, costs, and quality of life. The goal is to learn if thi…

This was a small pilot study to see if a full-scale trial was possible. It aimed to test whether an AI tool called CURE could help doctors write patient discharge summaries from the hospital more efficiently. The study planned to involve adult heart patients and their doctors at …

This study aims to find better ways to detect pancreatic cancer early in people at high risk due to family history or genetics. Researchers are collecting annual blood samples from 419 participants to look for biological markers that might signal cancer before symptoms appear. Th…

This study aims to build a large, diverse group of 21,000 people newly diagnosed with non-Hodgkin lymphoma to learn what affects their long-term health. It will collect detailed health information, lifestyle factors, and biological samples over time, but does not test a new treat…

This study aims to understand if metal implants (like plates, screws, or rods) used in children's bones release metal into their bloodstream. Researchers are measuring metal levels in the blood and tissues of 50 children aged 4-18 who have these implants. The goal is to learn if …

This study aims to find the ideal level of muscle relaxation for safely placing a breathing tube during surgery. Researchers will measure muscle twitch responses in 108 patients to determine which monitoring ratio provides the best conditions for this common procedure. The goal i…

This study is testing a new, non-invasive ultrasound technique called Super-resolution ultrasound (SRU) to see the tiny blood vessels inside the kidneys. Researchers want to compare these blood vessels in people with early-stage Autosomal Dominant Polycystic Kidney Disease (ADPKD…

This study aims to understand what causes spinal deformities and degeneration by analyzing tissue samples from 300 children and adults undergoing spinal surgery. Researchers will examine the molecular makeup of discarded surgical tissue to identify biological markers of disease. …

This study aims to create a single, standard test to understand why some physically active people handle exercise in low-oxygen conditions better than others. Researchers will measure factors like breathing, heart rate, and blood chemistry in 50 participants during a stepwise exe…

This study aims to see if a person's ability to absorb sugar in their gut can predict how much weight they will lose after bariatric surgery. Researchers will enroll 52 people, including those scheduled for surgery and healthy individuals, to measure sugar absorption and related …

This study aims to better understand how various brain diseases progress over time. Researchers will follow about 500 adults with symptoms of conditions like Parkinson's disease or dementia for several years. Participants will have yearly check-ups that may include brain scans, m…

This study aims to understand how treatment for scoliosis affects a young person's daily activity and back muscles. Researchers will track movement with wearable monitors and measure muscle stiffness with a special ultrasound in 200 teens before and after they receive a brace or …

This study aims to create a central collection of blood samples and health information from Florida patients with various brain blood vessel diseases, like stroke. Researchers will enroll 72 participants to build this resource, which will be used for future research to better und…

This study aims to see if blood tests taken during and after pregnancy can predict future heart problems in women who were born with a heart condition. Researchers will follow 100 pregnant women with congenital heart disease to see if changes in these blood markers over time give…

This study aims to see if measuring brain stiffness with a special, non-invasive MRI scan can serve as a new sign, or biomarker, for Alzheimer's disease. Researchers will enroll 450 people, including those with Alzheimer's, mild memory problems, and healthy individuals, to compar…

This study is testing whether regular, painless glucose (sugar) monitoring during pregnancy can help predict who might develop gestational diabetes or preeclampsia. Researchers will follow 100 pregnant women with risk factors, comparing those who use the non-invasive monitor plus…

This study aims to understand if tiny particles released by prostate cancer cells, found in blood and urine, change after surgery and if they relate to standard blood test results. Researchers will collect samples from about 100 men with prostate cancer before and after their sur…

This study aims to better understand specific brain changes, called white matter hyperintensities, seen on MRI scans. Researchers will compare brain images from 50 women with migraines, small vessel ischemic disease, or multiple sclerosis. The goal is to learn more about these co…

This Mayo Clinic study aims to learn more about irregular heart rhythms in adults with hypertrophic cardiomyopathy, a condition where the heart muscle thickens. Researchers are observing 260 participants using a small implanted heart monitor to track rhythm patterns over time. A …

This study aims to understand why prostate cancer sometimes comes back after radiation treatment. Researchers are testing if changes in a specific blood marker (CgA) after treatment can predict which patients are at higher risk of their cancer returning. The study involves 118 me…

This study is testing whether a new type of blood test can help doctors monitor patients with bile duct cancer (cholangiocarcinoma) after surgery. Researchers will check if specific markers in the blood can predict if the cancer is likely to come back or progress. The goal is to …