Mayo Clinic

This early-phase trial tests whether adding an immune-boosting drug (aldesleukin) to standard chemotherapy and another immunotherapy (nivolumab) can help control stomach cancer that has spread to the lining of the abdomen. About 15 adults with this advanced cancer will receive th…

This study tests a new combination for people with pancreatic cancer that cannot be surgically removed or has spread. It uses a light-activated drug (verteporfin) to make tumors more sensitive to immunotherapy (pembrolizumab), alongside standard chemotherapy. The goal is to see i…

This early study at Mayo Clinic tests whether ultra-low, anti-inflammatory doses of radiation can slow Parkinson's disease. Twenty people with early-stage Parkinson's will receive five daily radiation treatments guided by special brain scans. The main goal is to see if the treatm…

This study looks at whether giving vitamin D supplements to people with newly diagnosed lymphoma or chronic lymphocytic leukemia who have low vitamin D levels can improve their survival and delay the need for treatment. About 565 participants are being given vitamin D3 or a place…

This Phase 2 trial tests whether a patient's own stem cells, injected into the spinal fluid, can slow the progression of multiple system atrophy (MSA), a rare and fatal brain disease. The study involves 71 adults aged 30-70 with early-stage MSA. Researchers will measure changes i…

This phase II trial tests two types of radiation therapy (proton beam or IMRT) given in fewer, larger doses for men whose prostate cancer has returned or spread to a few spots after initial treatment. The main goal is to see if this shorter course causes fewer serious side effect…

This study tests a combination of two drugs—pemetrexed (chemotherapy) and pembrolizumab (immunotherapy)—in people with salivary gland cancer that has returned or spread. The goal is to see if this combo can shrink tumors or slow the disease. About 45 adults with advanced salivary…

This study tests whether a short course of two drugs, dasatinib and quercetin, can clear senescent (aging) cells in people with chronic kidney disease. The goal is to see if this reduces frailty and improves stem cell function. Thirty participants aged 40-80 with moderate-to-seve…

This phase 2 trial tests a combination of four drugs (carfilzomib, daratumumab, lenalidomide, and dexamethasone) in 17 people with high-risk multiple myeloma. The goal is to see if the treatment can clear even tiny amounts of cancer left after initial therapy, known as minimal re…

This phase 2 trial tests a fixed-dose combination of niraparib and abiraterone acetate plus prednisone in 8 men with metastatic castration-resistant prostate cancer that has a SPOP gene mutation. The drugs work by blocking cancer cell repair and reducing inflammation. The main go…

This phase II trial at Mayo Clinic tests whether estradiol, a form of estrogen, can help patients with a specific subtype of triple negative breast cancer that has a receptor called ER beta. The study enrolls 8 women with advanced or metastatic disease. Researchers will measure h…

This study looks at whether repairing the hip capsule (a layer of tissue around the joint) after keyhole hip surgery leads to better outcomes than leaving it unrepaired. About 250 adults aged 18 to 50 with hip pain from femoroacetabular impingement will be randomly assigned to on…

This study tests a new fetal surgery for unborn boys with a blocked urinary tract (LUTO). The procedure uses a tiny camera to see inside the bladder and clear the blockage, aiming to improve fluid levels and lung growth. About 10 pregnant women will be enrolled to see if the appr…

This study compares two treatments for eosinophilic esophagitis (EoE): swallowed budesonide (Eohilia) and injected dupilumab (Dupixent). Researchers want to see which one better improves esophageal diameter and reduces scarring after 12 weeks. The trial enrolls 60 adults with act…

This phase 2 trial tests a combination of two drugs—TTI-622 and pembrolizumab (Keytruda)—in about 10 adults with diffuse large B-cell lymphoma that has come back or not responded to treatment. TTI-622 blocks a protein called CD47 that cancer cells use to hide from the immune syst…

This study tests a new drug called iberdomide combined with three standard treatments (daratumumab, bortezomib, and dexamethasone) for people newly diagnosed with multiple myeloma. The goal is to find the best dose and see if the combination can kill more cancer cells. About 49 a…

This study offers girls from birth to age 17 the chance to freeze their ovarian tissue before medical treatments that could harm their fertility, such as chemotherapy or radiation. The tissue is removed surgically and stored. Later, if they want to have children, the tissue can b…

This study tests whether a vaccine (PDS0101) given alone or with an immunotherapy drug (pembrolizumab) can shrink HPV-related throat tumors before surgery. About 20 adults with advanced cancer that has spread to nearby lymph nodes will receive the treatment. The goal is to see if…

This study is testing whether a precise form of radiation called proton therapy can control head and neck cancer after surgery as well as standard X-ray radiation, but with fewer side effects. About 174 adults with newly diagnosed head and neck cancer will receive either proton t…

This study tests a program where community paramedics visit adults with diabetes who have had severe low blood sugar (hypoglycemia). The goal is to help them better manage their diabetes, prevent future emergencies, and improve their quality of life. About 150 participants from s…

This study tests whether a person's own stem cells can be safely injected into the spinal fluid to treat multiple system atrophy (MSA), a rare and serious brain disease. About 30 adults aged 30-80 with MSA will receive the treatment. The main goal is to check for side effects, an…

This study compares two approaches to prevent pancreatic leaks after Whipple surgery: giving antibiotics for a short time with a drug called octreotide versus giving antibiotics for a longer time. About 103 adults at intermediate or high risk for leaks will take part. The goal is…

This early-phase study tests a new treatment for multiple myeloma that has returned or stopped responding to standard therapies. The treatment uses a patient's own immune cells (T cells) that are specially trained to recognize and attack cancer cells carrying a protein called MUC…

This early-phase trial tests a drug called WSD0922-FU in 56 people with certain brain cancers (glioblastoma, anaplastic astrocytoma) or lung cancer that has spread to the brain or spinal cord. The drug blocks a protein called EGFR that helps cancers grow, and is designed to reach…

This study tests whether combining durvalumab (an immunotherapy) with lurbinectedin (a chemotherapy drug) can help people with advanced small cell lung cancer whose disease returned after standard treatment. About 29 adults who have already had chemotherapy and immunotherapy will…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 52 adults with this diagnosis will receive the combination therapy. The main goals are…

This study tests a small device, called the Coronary Sinus Reducer, in 35 people with a type of heart failure where the heart pumps well but still has trouble filling with blood. The device is placed in a vein of the heart to help lower pressure during exercise. The goal is to se…

This early-phase trial tests two drugs together—sonidegib and pembrolizumab—in 36 adults with advanced solid tumors that have spread. Sonidegib blocks a growth signal in cancer cells, while pembrolizumab helps the immune system attack the tumor. The main goals are to find the saf…

This study looks at whether ablation therapy (using heat or light to destroy abnormal cells) can control Barrett's esophagus, a condition that can lead to esophageal cancer. About 600 adults with high-grade dysplasia or early cancer will be treated and followed to see if the abno…

This study looks at whether using two fixation devices instead of one helps heal broken thigh bones near the knee. About 60 adults with this type of fracture will be treated within 72 hours of injury. Researchers will track surgery time, blood loss, hospital stay, and early compl…

This study tests a new treatment for ALS (Lou Gehrig's disease) using stem cells taken from the patient's own belly fat. The cells are injected into the fluid around the spine every 3 months for a year. The goal is to see if this treatment is safe and can slow down the disease. A…

This study tests a combination of drugs (selinexor, pomalidomide, dexamethasone, and sometimes carfilzomib) in 39 adults with multiple myeloma that has returned or no longer responds to standard treatments. The goal is to find the best dose and see how well the combo controls the…

This study tests two drugs, pirtobrutinib and venetoclax, for people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma. The goal is to see if the combination can make cancer undetectable using a sensitive blood test. The treatment length is guided by…

This study tests a new drug called parsaclisib added to standard chemotherapy (R-CHOP) for people with newly diagnosed, high-risk diffuse large B-cell lymphoma. About 50 adults will take part to find the best dose and see if the combination is safe and works better than standard …

This phase II trial compares a short course of high-dose radiation (over fewer days) to the standard longer course for people with glioblastoma, an aggressive brain cancer. The goal is to see if the shorter treatment is just as good at keeping patients alive while possibly causin…

This early-stage trial tests a specially modified virus (VSV-hIFNbeta-NIS) given through an IV to people with advanced or recurrent endometrial cancer. The virus is designed to attack cancer cells while leaving healthy cells alone, and it includes a tracer to see where it goes in…

This phase II trial tests a shorter course of radiation (hypofractionated) given before surgery for soft tissue sarcoma of the arms, legs, or trunk. The goal is to see if this approach reduces major wound complications after surgery. About 120 adults with localized, resectable sa…

This study looks at whether removing brain tumors with surgery after chemotherapy or radiation, but before the tumor grows back, is safe and helpful. About 40 adults with remaining tumor after prior treatment will be followed to see how they do compared to those who have surgery …

This study looks at whether a natural substance called fisetin can help people with advanced chronic kidney disease. Researchers will measure changes in inflammation, stem cell health, and physical frailty after 14 days of treatment. The study involves 30 adults aged 40-80 with m…

This study tests a 3-week course of radiation (using photons or protons) combined with chemotherapy for people with pancreatic cancer that hasn't spread. The goal is to see if this shorter treatment is safe and effective, either before surgery or as the main therapy. Researchers …

This pilot study at Mayo Clinic is testing a special low-calorie, high-protein tube feeding formula called Peptamen Intense VHP in 12 obese patients who rely on tube feeding. The goal is to see if it helps them lose weight while maintaining muscle mass, and also improves blood pr…

This study tests whether atorvastatin (Lipitor), a widely used cholesterol medication, can safely improve liver damage in people with NASH, a serious fatty liver disease. About 70 adults with confirmed NASH and liver scarring will receive either the drug or a placebo. The goal is…

This early-stage study tests whether delivering a patient's own stem cells directly into the artery that supplies the colon is safe for people with moderate to severe ulcerative colitis. Twenty adults who have not responded to at least two standard treatments will receive one dos…

This early-phase trial is testing whether combining two drugs—pembrolizumab (Keytruda) and ibrutinib (Imbruvica)—can safely treat advanced melanoma that cannot be removed by surgery. Pembrolizumab helps the immune system fight cancer, while ibrutinib blocks enzymes that help canc…

This study compares two types of radiation therapy—standard x-ray and proton beam—for people with breast cancer who have had surgery. The goal is to see which method causes fewer serious side effects or unplanned surgeries over two years. About 146 adults with stage I to III brea…

This early-stage study tests whether a person's own fat stem cells can safely help heal pressure ulcers or diabetic foot ulcers. Twelve adults will have a small amount of fat removed from their body, processed to extract stem cells, and then applied to their wound using a special…

This study compares two methods of prescribing high-intensity interval training (HIIT) for people in cardiac rehabilitation. Thirty adults with heart conditions will follow a 12-week exercise program to see which prescription approach improves fitness, heart function, and oxygen …

This study tests whether helping people who sleep less than 6.5 hours per night extend their sleep can lower their blood pressure. Researchers will compare an 8-week sleep coaching program to general health education in 110 adults with prehypertension or mild hypertension. The ma…

This study follows 20 adults with CSF1R-related leukoencephalopathy, a rare genetic brain disease, who are scheduled for a stem cell transplant. Researchers will measure changes in thinking, movement, and brain scans over time to see if the transplant helps stabilize or improve s…

This study follows 55 people aged 18-65 who have a meniscus root tear and undergo a specific surgical repair called transtibial pullout. Researchers will track knee function and arthritis progression over time to see if the procedure works well and what factors might lead to poor…

This early-stage trial tests whether a patient's own fat-derived stem cells, applied during surgery, can prevent dialysis fistulas from failing. About 74 adults with advanced kidney disease will receive either stem cells or a placebo. The goal is to see if the treatment improves …

This study at Mayo Clinic compares two FDA-approved weight-loss drugs, semaglutide and tirzepatide, against a placebo to see how they affect stomach emptying and feelings of fullness. Thirty adults with obesity or overweight plus prediabetes will receive weekly injections for 24 …

This study compares two standard treatments for acute infection after hip or knee replacement: a single surgery to clean the joint versus two planned surgeries. About 490 participants will be randomly assigned to one approach. The goal is to see which method better prevents the n…

This early-phase trial tests a new approach for recurrent ovarian, fallopian tube, or peritoneal cancer. Doctors take stem cells from the patient's fat tissue, infect them with a modified measles virus, and inject them into the abdomen. The idea is that the stem cells will delive…

This early-phase trial is testing whether combining a precise type of radiation (SBRT) with immunotherapy can safely treat pleural mesothelioma, a rare cancer of the lung lining. About 20 adults with confirmed mesothelioma will receive both treatments. The main goal is to see if …

This phase 2 study tests whether fisetin, a natural compound found in fruits and vegetables, can reduce dangerous inflammation and improve oxygen levels in hospitalized COVID-19 patients. About 80 adults aged 60+ (or younger with certain health conditions) will receive either fis…

This study tests if stem cells taken from a patient's own belly fat and injected into the spine can safely help restore movement and feeling after a spinal cord injury. About 40 adults with paralysis will receive the treatment. The goal is to see if this approach can improve func…

This study tests whether using ketamine or propofol for anesthesia at the start of heart surgery affects the risk of acute kidney injury. Researchers will enroll 200 adults undergoing complex heart surgery with a heart-lung machine. The goal is to see which drug leads to fewer ki…

This phase 2 trial tests whether metyrapone, a drug that lowers cortisol production, is safe and effective for people with mild autonomous cortisol secretion (MACS). About 30 participants will take the drug for a period, and researchers will track side effects and cortisol levels…

This study tests whether a fish skin device called Kerecis SurgiClose can help heal anal fistulas and related wounds that won't close on their own. Twenty adults with cryptoglandular fistulas will receive the fish skin patch during a procedure. Doctors will check if the fistula i…

This study tests whether MR-guided cryoablation—a procedure that freezes tumors—can effectively treat prostate cancer that has come back in the prostate bed. Researchers are enrolling 107 patients whose tumors are small and not suitable for surgery or radiation. The goal is to se…

This study tests whether transplanting a donor voice box (larynx) can safely restore voice, swallowing, and breathing in people with severe larynx damage or who have had their larynx removed. Ten adults will receive the transplant and be followed for five years. The trial is curr…

This study uses special brain scans (PET imaging) to measure amyloid buildup—a protein linked to Alzheimer's—in healthy older adults, people with mild memory problems, and those with dementia. Participants receive scans every 2-3 years for up to 20 years to see how amyloid change…

This study tests whether combining an AI-enhanced electrocardiogram (ECG) with a focused heart ultrasound can better detect structural heart disease in people without symptoms. About 2,705 adults with no known heart problems will get an AI-ECG, and if it flags a concern, they'll …

This study is testing a simple, less invasive way to detect Barrett's esophagus and esophageal cancer using a sponge on a string. Participants swallow the sponge, which collects cells from the esophagus. Researchers will analyze these cells to develop a lab test that can spot ear…

This study is testing a new blood test that looks for DNA changes to detect if liver cancer has come back or spread after surgery. Researchers at Mayo Clinic are enrolling 36 patients with early-stage liver cancer who are scheduled for surgery. The goal is to see if this test can…

This pilot study at Mayo Clinic tests a new SPECT/CT scanner called StarGuide NextGen. About 100 people who are already scheduled for a nuclear medicine scan will get an extra research scan. Doctors will compare the image quality to standard scans to see if the new system is bett…

This study involves 20 children and young adults with neuroendocrine tumors (like neuroblastoma) that have spread. Researchers are testing whether a special PET/CT scan using a radioactive tracer called 68Ga-DOTATATE can find tumors better than the standard MIBG scan. The goal is…

This study tests whether an artificial intelligence (AI) program can detect hypertrophic cardiomyopathy (HCM), a serious heart condition, using ECGs from standard machines, the Apple Watch, and the KardiaMobile device. Researchers will compare the AI's accuracy across these devic…

This study aimed to test a device called LabClasp that estimates blood lactate levels without a needle, using fluid from the skin. It was designed for healthy people during exercise and for ICU patients. However, the trial was withdrawn before any volunteers were enrolled, so no …

This study uses a special brain scan called DaTscan to look at how certain brain diseases affect the brain. Researchers will scan 500 adults with conditions like Parkinson's disease, dementia, mild cognitive impairment, or REM sleep behavior disorder. The goal is to see if DaTsca…

This study tests whether a special MRI technique called MR elastography can accurately measure high pressure inside the skull without needing a lumbar puncture (spinal tap). Researchers will compare the MRI results with standard tests in 200 people with and without high brain pre…

This study tests whether an Apple Watch, worn over a long period, can catch early signs of atrial fibrillation (a type of irregular heartbeat) in people who are at high risk but haven't been diagnosed yet. About 2,000 participants who had a previous ECG and a high AI risk score w…

Researchers at Mayo Clinic are testing whether measuring brain stiffness with a special MRI scan (magnetic resonance elastography) can serve as a new biomarker for Alzheimer's disease. The study will enroll 450 adults, including healthy volunteers, people with mild cognitive impa…

This study is testing whether a device called magnetocardiography (MCG) can quickly and accurately tell if chest pain is caused by a heart attack. Researchers at Mayo Clinic will use the MCG scanner on 1,000 emergency room patients with chest pain and compare its accuracy to stan…

This study tests a device called DESI-MS that analyzes tissue during brain tumor surgery to tell cancerous from healthy tissue. Researchers will check tissue samples from 285 adults undergoing glioma surgery. The goal is to see if this tool can give surgeons faster, more accurate…

This study tests a new type of MRI scan (qMT-MRI) to see if it can detect scarring in the kidneys of people with high blood pressure and narrowed kidney arteries. Researchers will compare the scan results to kidney function and injury markers. If it works, this could offer a safe…

This study tests a new ultrasound technique called super-resolution ultrasound imaging (SRUI) to see tiny blood vessels in the kidneys. Researchers will give an FDA-approved contrast agent called Definity to healthy volunteers and people with chronic kidney disease (CKD) who need…

This study looks at whether a special ECG and a blood test can find early signs of heart weakness in adult cancer survivors who had certain chemotherapy. Researchers will check how well these tests work compared to standard heart imaging. The goal is to gather information needed …

This study tests whether giving heated chemotherapy directly into the abdomen during surgery can prevent stomach or gastroesophageal junction cancer from returning in the abdominal lining. The treatment uses drugs cisplatin and paclitaxel, which are heated and circulated in the b…

This study tests whether offering women a simple self-collection kit for HPV testing at Express Care clinics (which have evening and weekend hours) increases cervical cancer screening rates. About 500 women aged 30–63 who are overdue for screening will either receive usual care o…

This study tests whether taking an over-the-counter probiotic (VSL#3® 450B) can prevent colitis (colon inflammation) and diarrhea in cancer patients receiving immunotherapy. Up to 45% of patients on these drugs develop this side effect. The trial enrolls adults with solid tumors …

This study tests whether a short course of two drugs (glecaprevir/pibrentasvir and ezetimibe) can prevent hepatitis C infection in people who receive a kidney, heart, lung, or pancreas from a donor with hepatitis C. About 200 participants who are hepatitis C-negative will take th…

This study tests whether combining a baby's first checkup after leaving the hospital with a lactation consultation helps more mothers breastfeed longer. About 246 mothers who plan to breastfeed will either get the combined visit or separate visits. Researchers will track breastfe…

This study compares two types of radiation therapy—proton therapy and standard intensity-modulated radiation therapy (IMRT)—given after surgery for cervical or endometrial cancer. The goal is to see if proton therapy causes fewer bowel side effects. About 120 women will fill out …

Researchers at Mayo Clinic are testing a mobile phone app designed to help women ages 45–55 identify and manage menopause symptoms. The app provides education and creates a personalized discussion guide for doctor visits. 900 women will participate, with half receiving the app an…

This Mayo Clinic study is testing whether eating fermented foods like yogurt, kimchi, and sauerkraut can improve gut microbiome diversity in people with long COVID. Forty adults with long COVID symptoms will either add fermented foods to their diet or continue as usual. Researche…

This study tests whether a virtual program called Lin Health can improve daily life for people with fibromyalgia. Researchers at Mayo Clinic will follow 300 adults with fibromyalgia to see if online behavioral health support reduces symptoms and improves function. The goal is to …

This study tests whether a diet rich in fermented foods (like yogurt and kimchi) is tolerable and can improve quality of life for survivors of critical illness, including severe COVID-19. The goal is to help restore gut health and reduce inflammation. The study involves 40 partic…

This study follows 50 people undergoing a minimally invasive procedure called percutaneous ablation to treat endometriosis in the abdominal wall. Researchers will measure how well symptoms improve and how quickly patients recover using standard pain and quality-of-life surveys. T…

This small pilot study at Mayo Clinic is testing whether Electromagnetic Transduction Therapy (EMTT) can help people with osteoarthritis of the foot or ankle. Twenty participants will receive the treatment, and researchers will measure changes in pain and daily function. The goal…

This study tests a new way to match dementia caregivers with each other for emotional support using a computer algorithm. Researchers want to see if matching based on personal preferences leads to better satisfaction and less stress than random matching. About 355 caregivers of p…

This phase 2 study tests whether fisetin, a natural compound found in fruits like strawberries, can reduce inflammation and frailty in adults aged 70 and older. Forty participants will receive either fisetin or a placebo pill. The goal is to see if fisetin lowers blood markers of…

This study tests a new radiation technique for men whose prostate cancer returns after surgery. Instead of many standard treatments, this approach uses daily scans to adjust the radiation beam precisely, potentially reducing side effects and shortening the number of sessions. Abo…

This study tests a smartphone app called PACTAID in 20 adults with type 1 diabetes. The app gives real-time advice during exercise to help keep blood sugar levels stable while using an automated insulin pump. Researchers will check if the app improves glucose control during and a…

This study tests three types of wave therapies—focused shockwave, radial pressure waves, and electromagnetic therapy—to treat leg injuries like muscle, cartilage, and bone damage. Researchers at Mayo Clinic will enroll 200 adults to see if these treatments reduce pain and improve…

This study at Mayo Clinic is testing whether focused shockwave therapy can reduce pain at the front of the knee after ACL reconstruction. Twenty adults who had ACL surgery using a tendon graft will receive either real shockwave or a sham treatment. Researchers will measure change…

This study tests whether fisetin, a natural substance found in strawberries and other fruits, can reduce frailty and inflammation in healthy women aged 70 and older. Participants will take fisetin or a placebo for a short time, and researchers will measure walking speed, inflamma…

This study tests if giving IV acetaminophen (like Tylenol) can control pain as well as opioids in people hospitalized with a small bowel obstruction. About 18 adults will be randomly assigned to receive either IV acetaminophen or usual opioid pain care. Researchers will measure p…

This study tests whether 10 weeks of supervised exercise training can improve heart function, oxygen use, and quality of life in people with heart failure and pulmonary hypertension. Forty participants will do three sessions per week at a cardiac rehab clinic. The goal is to see …

This study tests a biodegradable tube that is placed over a cut nerve during a leg biopsy. The goal is to see if it is safe and reduces common side effects like pain, redness, and swelling. Twenty adults with various nerve conditions are taking part, and half will get the tube wh…

This study tests whether giving ketamine during and after surgery can reduce chronic nerve pain in people with traumatic brachial plexus injuries. About 100 adults will receive a ketamine infusion during their reconstructive surgery and for 24 hours afterward. Researchers will me…

This study looks at whether removing a ureteral stent 3 days after kidney stone surgery is as safe and less bothersome than the usual 7 days. About 172 adults having simple stone treatment will be randomly assigned to either 3 or 7 days of stent placement. The goal is to see if a…

This Mayo Clinic study is testing whether a daily kava supplement can lower stress hormones and reduce burnout in 200 surgical nurses. Participants take either kava extract or a placebo for a set period, and researchers measure changes in cortisol levels and burnout scores. The g…

This study tests whether whole-body aerobic training (like brisk walking) or isolated leg training (with weights) better improves symptoms and quality of life in people with pulmonary arterial hypertension (PAH). About 45 participants with PAH will be assigned to one of the two e…

This pilot study from Mayo Clinic tests whether dry needling combined with therapeutic exercise can improve sleep in people with chronic neck pain and sleep problems. Researchers will enroll 28 adults aged 18–75 who have had neck pain for over 3 months and report poor sleep. The …

This study looks at two surgical methods to repair a specific type of meniscus tear in the knee. Researchers want to see if adding a step called centralization improves pain, function, and satisfaction compared to repair alone. About 54 adults with a torn meniscus and significant…

This study tests a mobile app called iPREPARED that helps patients and their caregivers prepare for a hospital stay. The app provides videos and tips to prevent or reduce delirium, a sudden confused state common in older adults. Researchers want to see if the app is easy to use a…

This study tests whether a virtual group therapy program can help caregivers of people with advanced cancer or serious life-limiting illness feel less hopeless and more connected to meaning and purpose. About 80 caregivers will participate in the program, which focuses on reducin…

This study tests if low-level laser therapy, combined with patient education, can reduce lower back pain. About 60 adults with moderate to severe pain will receive different frequencies of laser treatment. The goal is to see if this non-drug approach helps people feel better.

This study compares two pain management approaches after total knee or hip replacement: a combination of tramadol and oxycodone versus oxycodone alone. The goal is to see if the combination reduces the total amount of opioids needed and improves pain control with fewer side effec…

This study tests whether using a smaller ureteral stent (4.8 Fr instead of 7 Fr) reduces pain and discomfort after kidney stone surgery. About 100 adults who need a stent after surgery will be randomly assigned to one of the two sizes. Patients will report their pain daily until …

This study looks at whether aggressive weight loss using semaglutide can improve symptoms in people with a specific type of heart failure linked to obesity. About 81 participants with a BMI of 30 or higher and heart failure with preserved ejection fraction will receive either sem…

This pilot study from Mayo Clinic tests whether using a virtual reality headset can safely ease symptoms of gastroparesis, a condition where the stomach empties too slowly. Thirty adults with gastroparesis will try VR programs with games, meditation, and relaxation exercises. The…

This study tests whether a virtual world-based cardiac rehabilitation program is feasible for heart patients. Five participants will attend 24 online sessions over 8 weeks, including video visits with exercise physiologists and nurse coaches, plus group education. The goal is to …

This Mayo Clinic study tests a new device designed to clear fluid and debris from surgical drain tubes more effectively than the current method of using fingers. The trial will enroll 500 adults who have abdominal surgery with Jackson-Pratt drains. Nurses will rate how easy the d…

This trial tests whether having an empty bladder before CT simulation for prostate cancer radiation therapy is better than the usual full bladder. The goal is to see if it reduces urinary symptoms and makes daily treatments more consistent. About 168 men with prostate cancer will…

This study tests whether a new treatment called Family-Based Treatment for Primary Care (FBT-PC) can help children and teens with restrictive eating disorders. Instead of seeing a specialist, families work with their regular primary care provider, with support from a mental healt…

This study compares giving one dose of dexamethasone during knee replacement surgery versus two doses (one during surgery and one the next morning). The goal is to see which approach reduces pain, opioid use, and nausea while minimizing complications. About 339 adults undergoing …

This Mayo Clinic study tests whether a virtual reality meditation program called TRIPP can reduce the impact of fibromyalgia. Forty adults with fibromyalgia will use either the active VR meditation or a sham (fake) VR experience for two weeks each. Researchers will measure change…

This study tests a wearable device that uses mild electrical stimulation on the head to reduce motion sickness during virtual reality (VR) simulations. Forty adults aged 21-55 will participate at the Mayo Clinic in Arizona. The goal is to improve the technology so people can enjo…

This study tests a wristband called Cala TWO that uses mild electrical pulses to calm hand tremors in people with essential tremor. Twenty adults scheduled for deep brain stimulation surgery will use the device twice daily for three months. Researchers will measure tremor severit…

This study tests whether a home-based brain stimulation device (tDCS) combined with activity therapy can help improve cognitive and language problems in people with stroke, brain tumors, or neurodegenerative conditions like Parkinson's or Alzheimer's. Fifty-five participants will…

This early-stage study tests whether two drugs, dasatinib and quercetin, are safe and practical for people with mild cognitive impairment or Alzheimer's disease. The drugs aim to clear aging cells that may contribute to brain decline. Twenty participants aged 55 and older will be…

This study tests whether using virtual reality (VR) goggles during heart procedures can help patients feel more comfortable and reduce the amount of sedation medication needed. Ten adults scheduled for a heart ablation procedure will try VR as an extra relaxation tool. Researcher…

This study tests a new device called the Catheter Caps Case (C3) for dialysis patients. The goal is to see if it is more comfortable and easier to use than the usual gauze and tape. Ten adults with a dialysis catheter will try the device for 15 minutes, and researchers will measu…

This study tests whether using virtual reality (VR) during knee or hip surgery can help patients feel less anxious and need fewer sedating drugs. About 50 adults having surgery with a nerve block (awake but numb) will try VR and give feedback. The goal is to see if VR is a useful…

This study tests whether cutting a small nerve in the knee during a total knee replacement can reduce long-term pain. 178 adults having their first knee replacement will be randomly assigned to get either the standard surgery or the surgery plus the nerve cut. Researchers will tr…

This Mayo Clinic study tests whether reducing overall smartphone use and avoiding social media apps like Facebook, Instagram, and TikTok can lower anxiety symptoms in adults. One hundred participants with mild anxiety will be asked to change their phone habits, and their anxiety …

This Mayo Clinic study tests whether virtual reality (VR) can reduce anxiety, depression, and emotional distress in people receiving palliative care. Twenty terminally ill patients with a year or less to live will use VR to visit simulated travel destinations or activities they c…

This study compares a standard painkiller (bupivacaine) to a slow-release version (Exparel) for pain after eye removal surgery. 88 adults having their eye removed at Mayo Clinic will receive one of the two injections during surgery. The goal is to see if the slow-release drug pro…

This study looks at whether using a 7-inch footstool while on the toilet can improve constipation symptoms. About 85 adults with chronic constipation will use either the real footstool or a very low sham stool for comparison. The goal is to see if the squatting position helps inc…

This phase 2 study tests whether bone marrow stem cells can safely reduce pain in people with low back pain from worn-out facet joints. Forty participants will receive injections into the painful joints and be monitored for side effects and pain levels. The goal is to see if this…

This study compares high flow nasal cannula oxygen to standard oxygen therapy in 200 high-risk patients (with a BMI of 35 or higher) undergoing endoscopic ultrasound. The goal is to see if high flow oxygen reduces recovery time and prevents procedure pauses. Participants receive …

This study tests whether a non-invasive electromagnetic device can help men recover bladder control faster after prostate surgery. About 2,100 men who have urinary leakage after radical prostatectomy or HoLEP will receive the treatment or standard care. The goal is to see if it r…

This Mayo Clinic study is testing an AI system that uses wearable devices to measure pain after surgery. The goal is to find physical signs of pain and create a tool that helps doctors personalize pain medication, preventing overuse. The study involves 70 patients recovering from…

This study was designed to see if a biofeedback device called JOGO could help people with functional tremor, a condition where the body shakes uncontrollably. JOGO uses stickers on the skin to read muscle activity and then guides users through training sessions to reduce shaking.…

This early-stage trial tests whether injecting a person's own fat-derived stem cells into a painful arthritic hip is safe and might reduce pain. Researchers at Mayo Clinic are enrolling 24 adults aged 18-65 with hip osteoarthritis. The main goal is to check for side effects, whil…

This study looks at whether getting a nerve block both before and after surgery for thoracic outlet syndrome helps control pain better than getting it only before surgery. About 50 adults scheduled for first rib removal will take part. Researchers will measure pain levels and qua…

This study looks at whether a safe, non-invasive brain stimulation method called tDCS is practical and well-liked by hospitalized adults whose depression hasn't improved with standard treatments. Ten participants will receive 10 sessions of tDCS alongside their usual care. The ma…

This study looks at whether eating only during an early or late 8-hour window helps overweight adults lose weight and improve health. Researchers will track changes in weight and blood sugar over time. The goal is to find out which eating schedule works best and is easier to stic…

This Mayo Clinic study tracks 300 patients undergoing radiofrequency ablation for symptomatic thyroid nodules. Researchers use a simple questionnaire to measure changes in symptoms like discomfort or swallowing issues before and after the procedure. The goal is to better understa…

This pilot study at Mayo Clinic will test whether people with spontaneous coronary artery dissection (SCAD) feel more comfortable talking to an AI avatar or a human clinician before their appointment. About 150 patients will interact with the avatar and then rate their satisfacti…

This study was designed to see how a low dose of bevacizumab (Avastin) behaves in the body and whether it safely lowers a certain protein (VEGF-A) in people with kidney failure on dialysis. The goal was to gather information for a future trial on preventing dialysis access failur…

This study surveys over 21,000 nurses at Mayo Clinic to measure levels of moral distress, moral injury, and post-traumatic stress. Participants fill out questionnaires about their experiences and well-being. The goal is to understand how these issues vary by work setting, special…

This study examines whether senescent cells—sometimes called 'zombie cells' that accumulate with age—contribute to Long-Hauler Syndrome, a condition where COVID-19 symptoms persist long after the initial infection. Researchers at Mayo Clinic will compare markers of cellular aging…

This study creates a biobank of blood and fluid samples from up to 100 people who have received or will receive phage therapy for antibiotic-resistant bacterial infections. Researchers will review medical records and collect biospecimens to better understand how phage therapy wor…

This study looks at how radiation therapy for breast cancer affects tumor DNA and immune cells in the blood. Researchers will track these markers in 217 patients to see if they can predict treatment response. The goal is to use this information to customize radiation plans in the…

This observational study at Mayo Clinic looks at how immunotherapy drugs affect balance and hearing in cancer patients. Researchers will test 50 adults before and during treatment to see if their vestibular (balance) system changes over a year. The goal is to better understand si…

This study checks if some people with HIV might be cured. Ten patients who have had undetectable HIV for at least 6 months will stop their antiretroviral therapy under close medical supervision. Doctors will watch for the virus to come back. The goal is to see if the infection is…

This study uses a special PET scan to look at tau protein buildup in the brains of African Americans who are either cognitively normal or have dementia. Researchers hope to learn how these brain changes differ across racial groups. The study involves 240 participants and uses a t…

This large study at Mayo Clinic collects DNA and health information from 110,000 adults to learn how genetic sequencing can improve medical care. Participants provide saliva, blood, urine, and stool samples, and complete questionnaires about their family health history. The goal …

This study tests whether a biomarker found in saliva can predict how much weight people with obesity will lose when taking semaglutide. Researchers will compare weight changes in biomarker-positive and biomarker-negative participants over 24 weeks. The goal is to personalize obes…

This study looks at how diet, genetics, and gut bacteria work together to cause digestive problems like IBS, IBD, and celiac disease. Researchers will follow about 4,000 adults with and without these conditions to find patterns. The goal is to understand why some people get sick …

This Mayo Clinic study will follow 100 adults with narcolepsy or idiopathic hypersomnia who are starting a new treatment. Researchers will measure changes in blood pressure over 24 hours and track eye movements during a simple mental test before and after at least 3 months on med…

This study looks at whether regular blood tests can detect changes in stage IV breast cancer during treatment. Researchers will collect blood samples from 150 adults with metastatic breast cancer and analyze them for tumor DNA. The goal is to see if these tests can spot when the …

This study looks at genetic changes in blood and tumor samples from women with advanced hormone receptor-positive, HER2-negative breast cancer who are being treated with palbociclib and endocrine therapy. By comparing genetic material from the cancer tissue with that found in the…

This study looks at young women with hypothalamic amenorrhea (missed periods for months or years) to see if their condition is linked to early signs of heart disease. Researchers will use Fitbit trackers and questionnaires to measure stress, activity, and diet, along with blood t…

This pilot study at Mayo Clinic tests whether personalized education and genetic counseling can increase genetic testing in people with a first-degree relative who had pancreatic cancer. About 50 participants will receive tailored information and counseling. The goal is to see if…

This study collects blood and tissue samples from 300 people with breast cancer that has spread or come back. The goal is to create a large research registry that helps doctors understand why tumors spread and why people respond differently to treatments. Participants provide sam…

This study looks at whether data from wearable devices like smartwatches can track and even predict migraine headaches. Twenty adults with chronic migraine will use a phone app and a smart device to record heart rate and movement. The goal is to see if this information can help f…

This study uses a special ultrasound technique to monitor blood flow in the breast skin of women who have had a mastectomy and radiation therapy. Researchers want to see how fat grafting affects blood supply. Fifteen women who are already scheduled for breast reconstruction will …

This study tests whether an app that helps patients and doctors make decisions together can lower the number of CT scans for people with minor head injuries. About 370 adults aged 18-65 who are at low risk for serious brain injury will use the app in the emergency department. The…

This study follows up with people who took part in the CREST-2 trial to see how well treatments for carotid artery narrowing work over the long term. It includes about 2,480 participants who had either surgery, stenting, or intensive medical management. The main goal is to track …

This study follows 21,000 adults newly diagnosed with non-Hodgkin lymphoma to learn which factors—like genetics, lifestyle, and treatment—affect survival and quality of life. Researchers will track health outcomes over time without providing a new treatment. The goal is to improv…

This study from Mayo Clinic tests whether a smartphone app called Senyo Health can help connect people with substance use disorders to treatment through their primary care doctor. Sixty participants will use the app for 12 weeks, which includes therapy modules, weekly check-ins w…

This study tests whether measuring the strength of a muscle twitch in the wrist can help doctors decide the best time to insert a breathing tube during anesthesia. About 108 adults will be randomly assigned to one of three twitch-strength targets. The goal is to find the twitch l…

This study aims to find out how often cannabis withdrawal happens and how severe it is in patients with blood cancers who are hospitalized for a bone marrow transplant or CAR-T therapy. Researchers will track symptoms like mood changes and physical discomfort using a standard que…

This study is creating a statewide collection of blood samples and medical information from people with various brain blood vessel diseases, such as stroke and dementia. The goal is to build a resource that scientists can use in future research to better understand and potentiall…

This study compares two devices that track muscle relaxation during robotic or laparoscopic surgery: acceleromyography (AMG) and electromyography (EMG). Researchers want to see if one method leads to using less rocuronium, a muscle relaxant. About 400 adults having elective surge…

This Mayo Clinic study looks at how a single session of exercise affects fat tissue in healthy adults of different ages and weights. Researchers will take small fat samples from the belly before, right after, and three hours after a 30-minute bike workout. They want to see how ex…

This study tests new, improved fetoscopes—tiny telescopes used to perform surgery on a baby while still in the womb. Researchers at Mayo Clinic will enroll 100 pregnant women to see if the devices are safe and work well. The goal is to improve outcomes for conditions like twin-to…

This study is looking at tiny particles called extracellular vesicles that come from prostate cancer cells. Researchers want to see if levels of these particles in blood and urine can show how well surgery removed the cancer. They will compare samples from prostate cancer patient…

This study looks at how genetic testing results impact healthcare costs, use of medical services, and quality of life. Researchers will follow 100,000 adults who have already received their genetic results through the Tapestry program at Mayo Clinic. The goal is to understand whe…

This study follows 204 people with bladder cancer to see how their quality of life changes after treatment like surgery or radiation. Participants fill out surveys about physical function, pain, fatigue, anxiety, and bladder, bowel, and sexual health. The goal is to understand ho…

This study surveys 1,200 incarcerated women at a Florida prison to understand their cancer screening history, awareness, and barriers. The goal is to use this information to create a digital education module on cancer screening for prisons. No treatment or intervention is given; …

This study looks at how certain blood chemicals and blood vessel function relate to kidney disease severity in people with early-stage Autosomal Dominant Polycystic Kidney Disease (ADPKD). Researchers will measure homocysteine levels and blood vessel health in 80 participants age…

This study tests whether coaching or communication classes for primary care clinicians can improve patient satisfaction scores and reduce clinician burnout. About 45 Mayo Clinic providers will take part, filling out questionnaires before, right after, and two months after the tra…

This study looks at whether a short video or a virtual class better prepares people for ACL surgery. Researchers want to see which method leads to higher satisfaction, less anxiety, and better understanding. About 105 patients will take part, and they will be randomly assigned to…

This study uses special brain scans (PET imaging) to measure two key proteins, amyloid and tau, in people with different forms of Alzheimer's disease. Researchers want to see how these protein levels change over one year. The study involves 60 adults with typical or atypical Alzh…

This study looks at whether adding a special PET scan (18F-DOPA) to the standard MRI can help doctors better plan radiation treatment for people with certain brain tumors (malignant glioma). The PET scan may show tumor tissue more clearly than MRI alone. About 25 participants age…

This study was designed to collect and analyze fluid from the brain during epilepsy surgery. The goal was to look for signs of inflammation that might help develop new ways to control seizures in people who don't respond to medication. However, the study was withdrawn before any …

This study looks at how well treatments for childhood hip conditions (like hip dysplasia and Perthes disease) work over the long term. Researchers at Mayo Clinic are following 500 adults who were treated for these conditions as children. They will check how many needed another su…

This early-stage study tests a new type of marker that can be seen more clearly on ultrasound. It is placed in lymph nodes where breast cancer has spread. The goal is to see if the marker is safe, stays in place, and helps surgeons find the cancer during surgery. About 15 people …

This study screens 1000 adults aged 40 and older for MGUS, a condition with an abnormal blood protein that can sometimes lead to multiple myeloma. Researchers want to learn about genetic and immune factors behind MGUS, especially in diverse populations. The goal is to improve ear…

This study tests new MRI guidance software called Philips Interventional iSuite. Doctors will use it to guide needles for biopsies and tumor ablations in 12 patients already scheduled for these procedures. The goal is to see if the software helps place needles faster and more acc…

This study looks at two surgical methods for pelvic organ prolapse in women: robotic and open surgery. Researchers want to find out which costs more during the operation and how satisfied patients are with their scars and overall results. About 80 women having either type of surg…

This Mayo Clinic study looks at how a mother's stress, mood, sleep, and diet might affect levels of melatonin and an immune protein called sIgA in her breast milk. Researchers will follow 120 new mothers who are breastfeeding. The goal is to better understand these connections, n…

This study from Mayo Clinic is creating a large collection of blood, urine, stool, spinal fluid, and skin samples from 1000 people with ataxia and related genetic diseases, plus their healthy family members. The goal is to better understand the genetic and physical features of th…

This study tests a new brain implant system (CorTec Brain Interchange) in 12 people with drug-resistant epilepsy. The device records brain signals at high speed to detect abnormal activity that may lead to seizures. Unlike current devices that wait for a seizure to start, this sy…

This study tests whether a smartphone app that analyzes your voice can spot signs of depression and anxiety in people recovering from a heart attack. About 200 adults in cardiac rehab will use the app alongside their usual care. The goal is to see if voice analysis can help impro…

This study planned to check if blood tests taken during and after pregnancy could help predict future heart problems in women with adult congenital heart disease. The goal was to see if changes in these tests over time gave better warnings than a single test. However, the study w…

This study tests a brain implant that records brain activity and can deliver small electrical pulses to prevent seizures in people with epilepsy. Five participants will use the device along with a handheld tool to track mood, anxiety, and thinking. The main goal is to see if the …

This study tests whether a daily supplement called nicotinamide riboside can improve blood vessel flexibility in 200 healthy adults aged 35 to 70. Researchers will measure changes in artery stiffness over time. The goal is to understand how this supplement might support heart and…

This study looks at metal levels (like cobalt and chromium) in the blood of 60 adults after knee replacement surgery. Some had robotic-assisted surgery, others had the traditional method. The goal is to see if one approach leads to higher metal levels, which could affect safety. …

This study is testing a new blood test to see if it can find tiny bits of bile duct cancer left behind after treatment. Researchers will follow 100 adults who are having surgery to remove their cancer. The goal is to see if the test can predict if the cancer will come back sooner…

This observational study at Mayo Clinic aims to understand how genetics and environment contribute to disease before it begins. Researchers will collect biological samples, voice recordings, and survey data from 100,000 adult Mayo Clinic patients. The goal is to build a comprehen…

This study from Mayo Clinic aims to see how common a widened aorta (thoracic aorta dilatation) is among experienced weightlifters over age 35. Researchers will use ultrasound to measure the aorta in 45 participants who have been lifting weights for at least 5 years. The goal is s…

This study is looking for healthy adults to serve as a comparison group for a larger registry of people with adult congenital heart disease. Researchers will measure how well the heart and lungs work during exercise. The goal is to better understand the differences between health…

This study collects blood samples and medical information from people who have at least two relatives with pancreatic cancer, or one relative with pancreatic cancer and one with melanoma. The goal is to create a resource that scientists can use to study why pancreatic cancer runs…

This study uses a portable 48-hour EEG monitor to check for hidden seizures in people with early-onset Alzheimer's disease (ages 40-64). Researchers want to learn how common seizures and epilepsy are in this group. The study involves 20 participants and is purely observational, m…

This study aimed to see if using stitches that dissolve (absorbable) or stitches that need removal (non-absorbable) leads to better scar appearance and patient satisfaction after carpal tunnel or trigger finger surgery. It was planned for adults having these common hand surgeries…

This study looks at whether adding a polygenic risk score (a blood test that estimates genetic risk) to standard risk tools helps high-risk women make decisions about breast cancer prevention. About 737 women aged 35-75 with elevated risk are involved. The goal is to see if the s…

This study looks at how chemotherapy given before surgery affects the immune system in people with operable breast cancer. Researchers will collect blood samples to see if certain immune cells can predict how well the tumor responds to treatment. The goal is to better understand …

This study follows 1,599 people who had a first heart attack to see how their hearts remodel over time. Researchers want to link these changes to later heart failure. Participants are from several Minnesota counties and will be monitored for heart failure and death. No new drug o…

This study is collecting blood, stool, and urine samples from 1,000 people with Inflammatory Bowel Disease (IBD). Researchers will store these samples along with medical information to learn more about the disease and find ways to improve patient outcomes. The study does not invo…

This study follows 140 breast cancer patients who were part of the original BEAUTY trial. Researchers will collect blood and tissue samples and health information over time to understand why some breast cancers respond to standard chemotherapy and others do not. The goal is to id…

This study follows 419 people who do not have pancreatic cancer but are at high risk due to family history or genetic mutations. Researchers collect blood samples and health information over time to find markers that could predict or detect pancreatic cancer early. The goal is to…

This study looks at how amino acids (building blocks of protein) affect the release of glucagon and insulin compared to sugar alone. Researchers will test 30 adults who are healthy, have type 2 diabetes, or are obese. The goal is to better understand these hormone responses, not …

This study looks at whether losing weight through gastric bypass surgery changes bile acids differently than losing weight through a strict low-calorie diet. Researchers will measure bile acid levels in stool samples from 21 people with obesity. The goal is to understand if the s…

This study looks at heart rhythm problems in people with hypertrophic cardiomyopathy, a condition where the heart muscle is thicker than normal. Researchers want to see how often new rhythm issues like atrial fibrillation happen, and whether sleep apnea plays a role. About 260 ad…

This study looks at lymph node tissue from 200 adults who have had an organ transplant. Researchers want to find biomarkers that may help explain how well the transplant works. No new treatment is given; the goal is to learn more about the body's response to transplant surgery.

This study compares two devices that measure muscle response during surgery when the patient's arms are tucked at their sides. Researchers will check how accurate and consistent these monitors are in 40 people having surgery without muscle relaxants. The goal is to see which devi…

This study looks at genes in men with advanced prostate cancer that has spread and is no longer responding to hormone therapy. Researchers will analyze tissue, blood, and urine samples from 92 patients receiving a drug called abiraterone. The goal is to find genetic changes that …

This study aims to create a single, standardized test to measure how well people tolerate low oxygen (hypoxia) during exercise. Researchers will study 50 physically active adults to see why some handle it better than others, looking at factors like breathing, heart rate, and lung…

This study from Mayo Clinic will follow 4,000 athletes aged 12-30 to find better ways to diagnose concussions on the spot and set safe return-to-play rules. Researchers will also test if neck and vision training can help prevent brain injuries. The goal is to use simple tests and…

This study was designed to see if using a large language model (AI) called CURE can help doctors write discharge summaries for hospitalized patients more efficiently. The goal was to check if a larger trial is possible, focusing on how quickly patients could be enrolled. However,…

This study tests kidney transplant patients for genetic mutations that raise the risk of cancer and other diseases. Researchers want to see how common these mutations are and if testing helps guide better cancer screening. About 177 participants from Mayo Clinic are involved, all…

This study looks at whether a special microscope test of the fingernail folds (capillaroscopy) can help tell apart people who have a rare stomach condition called GAVE along with an autoimmune disease from those who have GAVE for other reasons. Researchers will compare the nail f…

This study tests a new electric bandage that creates small amounts of hydrogen peroxide to help heal wounds and prevent infections. Researchers at Mayo Clinic are putting the bandage on the healthy skin of 40 volunteers to see if it causes any discomfort, redness, swelling, or al…

This study from Mayo Clinic looks at whether certain gene variants make people more likely to form calcium oxalate kidney stones. Researchers will compare 2,900 adults with and without a history of kidney stones, analyzing blood samples and lifestyle factors. The goal is to bette…

This study interviews 80 immigrant men from Sub-Saharan Africa and the Caribbean who have been diagnosed with prostate cancer. Researchers want to understand how social factors like where they come from affect their health decisions, treatment, and survival. The goal is to identi…

This study tests whether a mild electrical current applied to the scalp (tDCS) can increase blood flow to the brain in people with Moyamoya disease or hardened brain arteries. Researchers will measure changes in blood flow using MRI and check if thinking skills improve. The study…

This study enrolls 3,000 people who have at least two blood relatives with pancreatic cancer but do not have the disease themselves. Researchers will follow them over time with health questionnaires every two years to track new cancer diagnoses. The goal is to build a resource re…

This study at Mayo Clinic aims to find people with rare genetic diseases who might benefit from a custom-made drug designed to target their specific genetic change. Researchers will collect samples like blood and skin biopsies to develop and test potential treatments. The goal is…

This study from Mayo Clinic measures how healthy children's immune systems respond to routine vaccines. Researchers will take blood samples before and after vaccination to track levels of various immune markers. The goal is to establish a range of normal responses, which could he…

This study tests a new ultrasound technique called shear wave elastography to measure stiffness in the wrist nerves and tissues of people with carpal tunnel syndrome. Researchers will compare these measurements with standard tests before and after treatment (surgery or steroid in…

This study is testing a new type of ultrasound called super-resolution ultrasound (SRU) to get a detailed look at the tiny blood vessels in the kidneys. Researchers will compare images from 34 people with ADPKD and healthy volunteers to see if SRU can detect differences in blood …

This study tests a new needle guide grid that helps doctors place needles more accurately during prostate biopsies. About 20 people scheduled for an MRI-guided biopsy or ablation will take part. The goal is to see if the grid improves needle placement by matching the target seen …

This study looks at whether a protein in the blood called chromogranin A (CgA) can help predict if prostate cancer will come back after radiation therapy. Researchers will measure CgA levels in 118 men before, during, and after treatment. The goal is to see if changes in CgA are …

This early study at Mayo Clinic tests whether using a device that massages the legs at night can help the brain clear waste products better in people with obstructive sleep apnea. The study involves 12 adults aged 50 and older who already use CPAP therapy. Researchers will measur…

This study looks at whether long-term inflammation raises the risk of endometrial cancer. Researchers are collecting blood and urine samples from 191 women having hysterectomy for either cancer or non-cancer reasons. They will compare markers of inflammation to better understand …

This study from Mayo Clinic looks at the molecular signals that control how children's bones grow at the growth plate. Researchers will collect tissue samples from 100 skeletally immature children and adults who are already having surgery that removes growth plate cartilage. The …

This study tests a new lab method to see how certain bone marrow cells take up nutrients like glucose and amino acids. Researchers will compare cells from people with a pre-cancer condition called MGUS to cells from healthy volunteers. The goal is to better understand the disease…

Mayo Clinic is creating a biobank of samples from 5,000 people with rare or undiagnosed diseases, along with their family members. Researchers will analyze DNA, RNA, and other samples to find markers and causes of these conditions. The goal is to build a library of information th…

This study follows 36 people with HER2-positive breast cancer who are receiving the drug T-DM1. Researchers want to learn how often and how severely the drug causes nerve damage (peripheral neuropathy), such as numbness, tingling, or pain. Participants will report their symptoms …

This study aims to learn more about diseases that affect the brain, such as Parkinson's disease and different types of dementia. Researchers will follow 500 adults with symptoms of these conditions over time, using brain scans and genetic tests to see how the diseases progress. T…

This study uses special brain scans (tau PET) to see how anti-amyloid immunotherapy affects tau protein buildup in people with mild Alzheimer's disease. About 135 participants will get two tau PET scans—one before starting treatment and another 12-18 months after finishing it. Th…

This study looks at whether children with metal implants (like plates, screws, or rods) have higher metal levels in their blood and tissues. Researchers want to understand if these metals cause any harm and if removing the implants or using different metals might be better. About…

This study looks at whether a blood test can find DNA from the HPV virus that causes cervical cancer. Researchers will collect blood samples from 18 people with cervical cancer before, during, and after treatment. The goal is to see if the test can predict how well treatment work…

This study from Mayo Clinic is looking at 100 people with autosomal dominant polycystic kidney disease (ADPKD) to see if certain markers in the blood and urine can predict how fast their kidney disease gets worse. Researchers will measure kidney size and function over time and co…

This study at Mayo Clinic will see if an Apple Watch can measure how well deep brain stimulation (DBS) controls essential tremor throughout the day. Fifty patients with DBS implants will wear the watch and perform simple tasks while the watch collects movement and heart data. The…

This study was designed to see if a drug called AEO could help protect brain function after radiation therapy for brain cancer. It planned to collect spinal fluid samples from adult patients to measure brain metabolism. However, the study was withdrawn before any participants wer…

This study tests a new imaging method called MR Elastography to measure how muscles and their surrounding tissues move in people with myofascial pain syndrome. Researchers will compare results from 106 participants, including those with chronic pain and healthy volunteers. The go…

This study will collect and analyze samples from 10,000 Mayo Clinic patients to understand how genes, environment, and lifestyle interact. Researchers will build a large database to find links between these factors and various diseases. The goal is to improve future medical care,…

This study looks at whether the bacteria living in your gut can help predict your risk of heart disease. Researchers will collect blood and stool samples from 700 adults undergoing heart catheterization to compare gut bacteria patterns with signs of inflammation. The goal is to b…

This study is collecting saliva, blood, and tissue from 100 adults with lymphedema to store for future research. The goal is to build a biorepository that can help scientists discover and validate biomarkers to improve microvascular treatment for lymphedema. Participants are not …

This study watches 500 acutely ill patients in a hospital telemetry unit to see how their heart rate, blood pressure, breathing, and oxygen levels change as their health gets worse or better. Researchers also track the types and amounts of medications and fluids given. The goal i…

This study aimed to see if using blood flow restriction (BFR) therapy during physical therapy helps people regain strength and movement after surgery for a torn biceps tendon or a dislocated kneecap. It was open to adults aged 18 to 80 having these specific surgeries. However, th…

This study collects spinal tissue from 300 children and adults during routine spine surgery. Researchers will analyze the tissue to understand the molecular causes of spine deformity and degeneration. The goal is to identify targets for future treatments.

This study follows 200 children aged 9-16 with scoliosis to see how spinal fusion surgery or bracing affects their muscle function and daily activity. Participants wear activity monitors and undergo muscle stiffness tests at the start and one year later. The goal is to learn more…

This pilot study is testing a device called LabClasp that measures blood sugar without needles. Researchers want to see if regular, non-invasive glucose checks can help predict gestational diabetes and preeclampsia in pregnant women. The study plans to enroll 100 women with at le…

This study looks at whether the way your gut absorbs sugar can predict how much weight you lose after bariatric surgery. Researchers will take small tissue samples from the intestine before and one year after surgery in 52 obese patients. They will check for changes in sugar abso…

This study uses advanced MRI scans and artificial intelligence to investigate small brain spots called white matter hyperintensities (WMH) in women with migraine. Researchers aim to tell these spots apart from those caused by other conditions like multiple sclerosis or small vess…

This study aimed to see if a rapid whole genome sequencing test on amniotic fluid could give faster genetic diagnoses for fetuses with suspected genetic diseases. Researchers planned to compare results from amniotic fluid and blood samples from up to 90 families. However, the stu…