Mayo Clinic

This early-phase trial tests a combination of two drugs—sonidegib and pembrolizumab—in people with advanced solid tumors that have spread. The goal is to find the safest dose of sonidegib when used with pembrolizumab and to see if the pair can shrink tumors. About 36 adults with …

This study compares two prosthetic hands—the SoftHand Pro and the i-Limb—in 36 people who have lost part of their forearm. Participants use each device for daily activities over 8 weeks to see which one helps them perform tasks better. The goal is to improve function and quality …

This study tests if stem cells taken from a patient's own fat and injected into the spine can safely help improve movement and feeling after a spinal cord injury. About 40 adults with paralysis will receive the treatment. The goal is to see if this approach can restore some funct…

This study looks at how well ablation therapy (using heat or light to destroy abnormal cells) works for people with Barrett's esophagus, a condition that can lead to esophageal cancer. About 600 adults with high-grade dysplasia or very early cancer will be treated and then checke…

This early-phase trial is testing whether combining a precise type of radiation (SBRT) with immunotherapy can help treat pleural mesothelioma, a rare cancer of the lung lining. The study involves 20 adults with confirmed mesothelioma and aims to see if the combination is safe and…

This study tests whether ultra-low doses of radiation, guided by special brain scans, can slow the worsening of motor symptoms in Parkinson's disease. Twenty adults aged 45 to 70 with early-stage Parkinson's will receive five daily radiation treatments. The goal is to see if this…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation can help people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 52 adults will receive the combination therapy to see if it improves survival and cont…

This study tests whether a special vaccine (PDS0101) given alone or with an immunotherapy drug (pembrolizumab) can shrink HPV-related throat tumors before surgery. About 20 adults with advanced cancer that has spread to nearby tissues or lymph nodes will receive the treatment. Th…

This study is testing whether a shorter, more intense course of radiation has fewer side effects for men whose prostate cancer has returned and spread to a few lymph nodes. It compares two radiation methods: proton beam therapy and standard IMRT. The main goal is to see which app…

This study is testing whether a combination of two drugs, niraparib/abiraterone and prednisone, can help control advanced prostate cancer that has spread and has a specific genetic mutation called SPOP. The treatment aims to stop cancer cells from repairing themselves and reduce …

This study tests whether a virtual world-based cardiac rehabilitation program is feasible for heart patients. Five participants will use an online program to improve their cardiovascular health and track hospital readmissions. The goal is to see if this approach can help patients…

This study tests if low-level laser therapy (LLLT) plus educational materials can reduce lower back pain. About 60 adults with moderate to severe pain will receive different frequencies of laser treatment. Researchers will track pain changes using a standard 0-10 scale.

This study looks at whether aggressive weight loss using semaglutide can improve symptoms in people with a specific type of heart failure linked to obesity. About 81 participants with a BMI of 30 or higher will receive either semaglutide or a placebo. The main goal is to measure …

This study looks at whether eating only during an early or late 8-hour window helps overweight adults lose weight. About 100 participants will follow one of two eating schedules for a set time. Researchers will track weight changes, blood sugar levels, and any challenges people f…

This study looks at how chemotherapy given before surgery changes the immune system in people with operable breast cancer. Researchers will collect blood samples from 38 participants to see if certain immune cells are linked to how well the tumor responds to treatment. The goal i…

This study aims to see if how the small intestine absorbs sugar can predict how much weight people lose after bariatric surgery. Researchers will compare obese patients scheduled for surgery with lean individuals. They will also check for gene changes that might affect sugar abso…

This study follows 1,599 people who had their first heart attack to see how the heart's shape and function change over time. Researchers want to understand which patterns of remodeling lead to heart failure. Participants are from several Minnesota counties and are not receiving a…

This study tests whether a new treatment for restrictive eating disorders (like anorexia) can work in a primary care setting for children and teens. About 200 participants will try Family-Based Treatment for Primary Care (FBT-PC), which involves caregivers in the process. The goa…

This study looks at whether a substance in the blood called chromogranin A (CgA) can help predict if prostate cancer will come back after radiation therapy. Researchers will measure CgA levels before, during, and after treatment in 118 men with prostate cancer. The goal is to see…

This study looks at whether taking nicotinamide riboside, a form of vitamin B3, can improve blood vessel function in healthy adults aged 35 to 70. Researchers at Mayo Clinic will measure changes in artery stiffness using a simple finger test. The goal is to understand how this su…

This study uses special brain scans to measure two proteins, amyloid and tau, in people with different forms of Alzheimer's disease. Researchers want to see how these protein levels change over one year. The study involves 60 adults with typical or atypical Alzheimer's, including…

This study follows 204 people with early to mid-stage bladder cancer to see how their treatment (surgery or radiation) affects their daily life. Participants fill out surveys about physical function, pain, fatigue, mood, and social activities before and after treatment. The goal …

This study will enroll 4,000 athletes aged 12–30 to improve how concussions are diagnosed on the spot and set safer return-to-play rules. Researchers will also test whether neck training and vision exercises can help prevent brain injuries. The goal is to find blood markers that …

This study looks at the molecular signals that control how bones grow after a growth plate injury. Researchers will analyze tissue samples from 100 children and teens who are already having surgery. The goal is to find ways to either speed up or slow down bone growth in the futur…

This study is creating a statewide collection of blood samples and medical information from 72 people with various brain blood vessel diseases, such as stroke, mini-stroke, and vascular dementia. The goal is to provide a resource for future research to better understand these con…

This study looks at how well a smartphone app works to help primary care clinics screen for and treat substance use disorders. About 60 adults who already have a primary care provider at Mayo Clinic will use the app to connect with care. The goal is to understand what helps or ge…

This study collects blood and health information from 1,000 adults with ataxia or related genetic diseases (and their healthy family members) to build a research repository. The goal is to better understand how genes and symptoms connect in these rare conditions. No new treatment…

This study aims to measure and understand the levels of moral distress, moral injury, and post-traumatic stress symptoms among nurses at Mayo Clinic. Researchers will survey approximately 21,300 nursing staff members to identify which workplace settings and personal factors are l…