110,000 patients join massive DNA study to unlock disease secrets

NCT ID NCT05212428

Ongoing Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This large study at Mayo Clinic collects DNA and health information from 110,000 adults to learn how genetic sequencing can improve medical care. Participants provide saliva, blood, urine, and stool samples, and complete questionnaires about their family health history. The goal is to find genetic variants that raise disease risk and to build a database that helps doctors prevent, diagnose, and treat illnesses more effectively.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors use genetic information to predict, prevent, or better treat diseases, and improve how genomic data is used in routine care.
What could go wrong: This is an observational study, not a treatment trial. It may not directly change care for participants, and findings may take years to apply in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hereditary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GENETIC DISORDER

Contacts and locations

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Locations

Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

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