Genetic score may guide breast cancer prevention choices
NCT ID NCT04474834
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether adding a polygenic risk score (a blood test that estimates genetic risk) to standard risk tools helps high-risk women make decisions about breast cancer prevention. About 737 women aged 35-75 with elevated risk are involved. The goal is to see if the score influences their choice to take preventive medication, have risk-reducing surgery, or get more frequent imaging.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Polygenic risk score (genetic test)
What this could lead to
If successful, this could help doctors and patients make more informed decisions about breast cancer prevention, potentially reducing unnecessary treatments or improving early detection.
What could go wrong
This is an observational study, not a treatment trial. The polygenic risk score may not significantly change decisions, and its long-term impact on cancer rates is not being directly measured.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Mayo Clinic
Scottsdale, Arizona, 85259, United States
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Mayo Clinic
Jacksonville, Florida, 32224-9980, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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Northwestern University
Evanston, Illinois, 60208, United States