Brain scans track tau changes after Alzheimer's antibody treatment
NCT ID NCT06723015
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study uses special brain scans (tau PET) to see how anti-amyloid immunotherapy affects tau protein buildup in people with mild Alzheimer's disease. About 135 participants will get two tau PET scans—one before starting treatment and another 12-18 months after finishing it. The goal is to learn whether clearing amyloid plaques also slows tau spread, which could improve future treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
18F-AV-1451 (a radioactive tracer for tau PET scans)
What this could lead to
If successful, this could help doctors understand whether anti-amyloid therapies slow tau spread in the brain, guiding future Alzheimer's treatment.
What could go wrong
This is an observational imaging study, not a treatment trial. It may not show clear changes, and results may not apply to all patients.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ALZHEIMER DISEASE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Mayo Clinic
Rochester, Minnesota, 55905, United States