Voice box transplant trial hopes to give speech back to patients

NCT ID NCT03269396

Terminated Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tests whether transplanting a donor voice box (larynx) can safely restore voice, swallowing, and breathing in people with severe larynx damage or who have had their larynx removed. Ten adults will receive the transplant and be followed for five years. The trial is currently on hold.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: larynx allograft (donor voice box)
What this could lead to: If successful, this could offer a way to restore natural voice, swallowing, and breathing for people who have lost larynx function due to injury or surgery.
What could go wrong: This is a very early, small study (10 people) that is currently suspended. The procedure carries major risks, including rejection of the transplant and the need for lifelong immune-suppressing drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chondrosarcoma laryngeal carcinoma laryngeal disorder laryngostenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LARYNGECTOMY LARYNX LARYNX DISEASE LARYNX FRACTURE LARYNX STENOSIS

Contacts and locations

Locations

Mayo Clinic in Arizona

Phoenix, Arizona, 85054, United States

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