New ultrasound technique could improve breast reconstruction after radiation

NCT ID NCT04992650

ENROLLING_BY_INVITATION Knowledge-focused Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses a special ultrasound technique to monitor blood flow in the breast skin of women who have had a mastectomy and radiation therapy. Researchers want to see how fat grafting affects blood supply. Fifteen women who are already scheduled for breast reconstruction will be enrolled. The goal is to learn more about skin health after radiation and fat grafting, which could lead to better outcomes in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fat grafting
What this could lead to: If successful, this could help doctors better understand how fat grafting affects blood flow in radiated breast skin, potentially improving reconstruction outcomes.
What could go wrong: This is a very small, early observational study with only 15 participants, so results may not apply to everyone. It is not testing a treatment, only measuring blood flow.

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Conditions

The condition(s) this trial relates to.

breast cancer Radiation Fibrosis Syndrome radiation pneumonitis radiodermatitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST RECONSTRUCTION FAT GRAFTING RADIATION DERMATITIS RADIATION FIBROSIS

Contacts and locations

Locations

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

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