Can fewer, stronger radiation doses before sarcoma surgery reduce wound problems?
NCT ID NCT04562480
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tests a shorter course of radiation (hypofractionated) given before surgery for soft tissue sarcoma of the arms, legs, or trunk. The goal is to see if this approach reduces major wound complications after surgery. About 120 adults with localized, resectable sarcoma are enrolled. The study compares the wound complication rate to standard radiation schedules.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Hypofractionated radiation therapy
- What this could lead to
- If successful, this could lead to a shorter, more convenient radiation schedule before sarcoma surgery with fewer wound healing problems.
- What could go wrong
- This is a mid-stage trial with 120 participants, so results may not apply to everyone. The higher daily radiation dose could increase side effects like wound complications or tissue damage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Mayo Clinic in Arizona
Scottsdale, Arizona, 85259, United States
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Mayo Clinic in Florida
Jacksonville, Florida, 32224, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States
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Other studies related to the condition(s) this trial covers.
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