Can fewer, stronger radiation doses before sarcoma surgery reduce wound problems?
NCT ID NCT04562480
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial tests a shorter course of radiation (hypofractionated) given before surgery for soft tissue sarcoma of the arms, legs, or trunk. The goal is to see if this approach reduces major wound complications after surgery. About 120 adults with localized, resectable sarcoma are enrolled. The study compares the wound complication rate to standard radiation schedules.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Hypofractionated radiation therapy
What this could lead to
If successful, this could lead to a shorter, more convenient radiation schedule before sarcoma surgery with fewer wound healing problems.
What could go wrong
This is a mid-stage trial with 120 participants, so results may not apply to everyone. The higher daily radiation dose could increase side effects like wound complications or tissue damage.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic in Arizona
Scottsdale, Arizona, 85259, United States
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Mayo Clinic in Florida
Jacksonville, Florida, 32224, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States