Could a few days of radiation beat weeks for brain cancer?

NCT ID NCT05781321

Ongoing Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This phase II trial compares a short course of high-dose radiation (over fewer days) to the standard longer course for people with glioblastoma, an aggressive brain cancer. The goal is to see if the shorter treatment is just as good at keeping patients alive while possibly causing fewer side effects. About 170 adults with confirmed glioblastoma are participating.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: short course radiotherapy (accelerated hypofractionated radiation therapy)
What this could lead to: If successful, this could offer a more convenient and less toxic radiation option for glioblastoma patients without compromising survival.
What could go wrong: This is a mid-stage trial with 170 participants, so results may not apply to all patients. The shorter course might not be as effective as standard treatment, and there is still risk of side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA

Contacts and locations

Locations

Mayo Clinic Health System in Albert Lea

Albert Lea, Minnesota, 56007, United States
Mayo Clinic Health System-Eau Claire

Eau Claire, Wisconsin, 54701, United States
Mayo Clinic Health System-Franciscan Healthcare

La Crosse, Wisconsin, 54601, United States
Mayo Clinic Health Systems-Mankato

Mankato, Minnesota, 56001, United States
Mayo Clinic Radiation Therapy - Northfield

Northfield, Minnesota, 55057, United States
Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States
Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980, United States
Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

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