Could a few days of radiation beat weeks for brain cancer?
NCT ID NCT05781321
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II trial compares a short course of high-dose radiation (over fewer days) to the standard longer course for people with glioblastoma, an aggressive brain cancer. The goal is to see if the shorter treatment is just as good at keeping patients alive while possibly causing fewer side effects. About 170 adults with confirmed glioblastoma are participating.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
short course radiotherapy (accelerated hypofractionated radiation therapy)
What this could lead to
If successful, this could offer a more convenient and less toxic radiation option for glioblastoma patients without compromising survival.
What could go wrong
This is a mid-stage trial with 170 participants, so results may not apply to all patients. The shorter course might not be as effective as standard treatment, and there is still risk of side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota, 56007, United States
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Mayo Clinic Health System-Eau Claire
Eau Claire, Wisconsin, 54701, United States
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Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin, 54601, United States
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Mayo Clinic Health Systems-Mankato
Mankato, Minnesota, 56001, United States
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Mayo Clinic Radiation Therapy - Northfield
Northfield, Minnesota, 55057, United States
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Mayo Clinic in Arizona
Scottsdale, Arizona, 85259, United States
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Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980, United States
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States